Meniscus Tear Injury
Ross Hauser, MD.
Meniscal tear injury treatment article highlights:
- single stem cell therapy injection following meniscus knee surgery can provide knee pain relief
- doctors document meniscus tissue regrowth
- mesenchymal stem cells have the potential to improve the overall condition of the knee joint
- Meniscal repair offers the potential to avoid the long-term articular cartilage deterioration that has been shown to result after meniscectomy
- Doctors say stem cell therapy will become the new clinical strategy for the treatment for meniscus tears
In research in the Journal of Bone and Joint Surgery, doctors have found that a single stem cell injection following meniscus knee surgery may provide knee pain relief and aid in meniscus regrowth. In this study, patients received a single injection of adult stem cells following the surgical removal of all or part of a torn meniscus. These patients reported a significant reduction in pain. Further, some meniscal tissue regrew! Up to 15 percent increase in meniscal volume at one year. There was no additional increase in meniscal volume at year two. (Comment: Maybe they should have given more than one injection.)
That question was answered in the American Academy of Orthopaedic Surgeons’ press release. “The results of this study suggest that mesenchymal stem cells have the potential to improve the overall condition of the knee joint,” said Dr. Vangsness (a study author). “I am very excited and encouraged” by the results. With the success of a single injection, “It begs the question: What if we give a series of injections?”1
Meniscus repair with Stem Cell Therapy
Again, we have to ask, if it works so well in rebuilding meniscal tissue, why have the surgery in the first place? It does say multiple injections may benefit the patient more. It seems we have written very often that single injections are not Prolotherapy; single PRP (Platelet Rich Plasma) injections are not PRP treatments; and now single Stem Cell Therapy injections are probably more effective if given more often? Sounds like Comprehensive Prolotherapy performed at Caring Medical, ie multiple injections of various and supportive elements to fit the individual case of the the patient.
Surgical Failure in one in four knees after five years
A recent article published in the Journal of Bone and Joint Surgery sheds some light unto why doctors are looking for an adjunct and patients are looking for alternative treatments. The reason poor surgical options for meniscal tears.
Terms used in this study:
- “Meniscal repair” refers to the surgical repair of the meniscal cartilage.
- “Meniscectomy” refers to partial or complete removal of the meniscus of the knee.
In short, doctors speculate that it is better to repair the meniscus than remove it. Look at the research: “Meniscal repair offers the potential to avoid the long-term articular cartilage deterioration that has been shown to result after meniscectomy. Failure of the meniscal repair can occur several years postoperatively. Limited evidence on the long-term outcomes of meniscal repair exists.”
In light of this information, researchers sought to find out how patients did in the long term with a surgical repair of the meniscus as opposed to a removal of part or whole of the tissue: “A systematic review of the outcomes of meniscal repair at greater than five years postoperatively demonstrated very similar rates of meniscal failure (22.3% to 24.3%) for all techniques investigated.”2
The surgical repair and the surgical removal scored about the same. A lot of failures. So the idea of repairing instead of removing seems to lose credibility in the long run.
As a side note, many readers comment that people who are against surgery do these studies. The reader should note the citations. This one is from The Journal of Bone & Joint Surgery. Almost every study we cite is surgeons writing for surgeons. Hardly anti-surgical groups!
- meniscectomy accelerates degenerative joint changes
- partial meniscectomy is one of the most common orthopedic procedures, yet rigorous evidence of its efficacy is lacking
In one recent study from the surgical journal The Journal of Arthroscopic and Related Surgery, the number of meniscectomies performed alarmed researchers. In fact it is concerning: “This study found that meniscectomy was performed in 65% of meniscus tears. This is concerning because studies have shown that, regardless of knee stability obtained after ACL reconstruction, meniscectomy accelerates degenerative joint changes.”3
On December 24, 2013, the New England Journal of Medicine published an article entitled :”Arthroscopic Partial Meniscectomy versus Sham Surgery for a Degenerative Meniscal Tear.”
This was the work of Finnish researchers who recognized that arthroscopic partial meniscectomy is one of the most common orthopedic procedures, yet rigorous evidence of its efficacy is lacking.
So what they did was to conducted a multicenter, randomized, double-blind, sham-controlled trial in 146 patients 35 to 65 years of age who had knee symptoms consistent with a degenerative medial meniscus tear and no knee osteoarthritis.
Patients were randomly assigned to arthroscopic partial meniscectomy or sham surgery. Then a scoring system was designed to measure pain, symptom severity and knee pain after exercise at 12 months after the procedure.
the outcomes after arthroscopic partial meniscectomy were no better than those after a sham surgical procedure
What they found was “In this trial involving patients without knee osteoarthritis but with symptoms of a degenerative medial meniscus tear, the outcomes after arthroscopic partial meniscectomy were no better than those after a sham surgical procedure.”4
This is not the first study this year to question the value of meniscal surgery. Earlier in 2013 research published in the American Journal of Sports Medicine showed what little value meniscectomy has. Researchers compared meniscectomy to nonoperative treatment for meniscus tears.2 They specifically studied degenerative horizontal tears of the medial meniscus and hypothesized that surgical treatment would produce better outcomes that nonoperative strengthening exercises.
Study shows meniscectomy did not provide better functional improvement than those found in nonoperative group
This study was a randomized controlled trial with the highest level of evidence (level 1). The study had 102 patients with medial meniscus tears – 81 women and 21 men with the average age of 53.8.
Fifty patients underwent arthroscopic menisicectomy while 52 participated in nonoperative strengthening exercises. The results did not match up the to researchers hypothesis. At the two year follow-up there was no difference in pain relief, improved knee function or patient satisfaction. Results also showed that meniscectomy did not provide better functional improvement than the nonoperative group.5
But what was the difference between these two groups? One group of patients underwent invasive surgery, had tissue remove, and will likely experience long-term meniscus degeneration.
In fact, most surgical meniscus treatments have, “all have a high long-term failure rate with the recurrence of symptoms including pain, instability, locking, and re-injury. The most serious of the long-term consequences is an acceleration of joint degeneration.”6
Meniscus Tear Treatments Stem Cell Therapy, Platelet Rich Plasma Therapy and Prolotherapy
What does this mean for the person with a degenerated knee? Osteoarthritis of the knee (and elsewhere) is not merely an articular cartilage disease, but a disease of the whole joint. It involves the menisci, subchondral bone, stem cells, ligaments, synovium, joint fluid, and other components of the joint. As such, whatever treatment is given for degenerative knee arthritis should be comprehensive. Experienced Prolotherapists use comprehensive Hackett-Hemwall Prolotherapy to treat many of the structures of the degenerated joint, including the menisci, articular cartilage, ligaments, tendons and the synovium, and joint fluid. This is one of the reasons so many injections are given per patient and why so much solution is used. For extreme cases of joint degeneration,stem cell injection therapy or Bone Marrow Prolotherapy is used. In this procedure bone marrow (with its stem cells) is used as the proliferant for inside the joint. It has been shown in other studies that bone marrow stem cells can be used to regenerate meniscus tissue. The extent of joint degeneration will determine what solutions are used and how many visits are needed. Contact us for more information.
A group of researchers at Hiroshima University in Japan studied surgical alternatives to a torn meniscus7. They were aware of the poor outcome of meniscectomies and of alternative treatments. They did, however, hear of the promising results of using mesenchymal stem cells in regenerating and repairing tissue. They conducted a study that transplanted mesenchymal stem cell from the tibia of rats to the torn meniscus in each rat. The stem cells were taken from the bone marrow of the tibia, harvested and transplanted into the torn meniscus. The results were promising, showing that mesenchymal stem cells could in fact proliferate and contribute to the healing of menisci. The results were so promising that they concluded “we are confident that the mesenchymal stem cell transplantation will become the new clinical strategy for the treatment for meniscus tears.”
In 2010 we published our findings on Prolotherapy for meniscal tears. We perfromed a retrospective study involving 24 patients, representing 28 knees, whose primary knee complaints were due to meniscal pathology documented by MRI. The average number of Prolotherapy visits was six and the patients were followed on average 18 months after their last Prolotherapy visit. Prolotherapy caused a statistically significant decline in the patients’ knee pain and stiffness. Starting and ending knee pain declined from 7.2 to 1.6, while stiffness went from 6.0 to 1.8.
Prolotherapy caused large improvements in other clinically relevant areas such as range of motion, crepitation, exercise, and walking ability.
Patients stated that the response to Prolotherapy met their expectations in 27 out of the 28 knees (96%). Only one out of the 28 patients ended up getting surgery after Prolotherapy.
Based on the results of this study, Prolotherapy appears to be an effective treatment for meniscal pathology. 7
1. Stem Cell therapy following Meniscal Surgery http://newsroom.aaos.org/media-resources/Press-releases/stem-cell-therapy-following-meniscus-knee-surgery-may-reduce-pain-restore-meniscus.htm
2. Nepple JJ, Dunn WR, Wright RW. Meniscal repair outcomes at greater than five years: a systematic literature review and meta-analysis. J Bone Joint Surg Am. 2012 Dec 19;94(24):2222-7. doi: 10.2106/JBJS.K.01584
3. Noyes FR, Barber-Westin SD. Treatment of meniscus tears during anterior cruciate ligament reconstruction. Arthroscopy. 2012 Jan;28(1):123-30. doi: 10.1016/j.arthro.2011.08.292. Epub 2011 Nov 9.
4. Sihvonen R, Paavola M, Malmivaara A, et al. Arthroscopic Partial Meniscectomy versus Sham Surgery for a Degenerative Meniscal Tear. N Engl J Med 2013; 369:2515-2524December 26, 2013DOI: 10.1056/NEJMoa1305189
5. A Comparative Study of Meniscectomy and Nonoperative Treatment for Degenerative Horizontal Tears of the Medial Meniscus Am J Sports Med May 23, 2013 ; published online before print May 23, 2013.
6. Hauser R, Phillips H, Maddela HS. Hilary J. The Case for Utilizing Prolotherapy as First-Line Treatment for Meniscal Pathology: A Retrospective Study Shows Prolotherapy is Effective in the Treatment of MRI-Documented Meniscal Tears and Degeneration. Journal of Prolotherapy. 2010;(2)3:416-437.
7. Izuta Y, et al. Meniscal repair using bone marrow-derived mesenchymal stem cells: experimental study using green fluorescent protein transgenic rats. The Knee. 12 (2005) 217 – 223.