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Caring Medical
Regenerative Medicine Clinics

Chicagoland office
715 Lake Street, Suite 600
Oak Park, IL 60301
708.393.8266 Phone

Southwest Florida office
9738 Commerce
Center Court
Fort Myers, FL 33908
239.303.4069 Phone

855.779.1950 Fax

Degenerative joint disease treatment | Osteoarthritis


In this article Ross Hauser MD will explain the non-surgical advantages of Prolotherapy, Platelet Rich Plasma Therapy, and Stem Cell Therapy for the treatment of Degenerative Joint Disease better known as osteoarthritis.

Degenerative joint disease (DJD) is a painful degenerative condition that results in the deterioration of the cartilage tissues that support the weight-bearing joints in the body. Once the cartilage is thinned or lost, the constant grinding of bones against each other causes pain and stiffness around the joint. Abnormal and excess bone formations (bone spurs) grow from the damaged bones, causing further pain and stiffness.


It is important to note that, although associated with old age,osteoarthritis and degenerative joint disease are not simply a result of the aging process, nor are they a result of general wear and tear on joints.

Osteoarthritis and degenerative joint disease almost always begin as a ligament weakness resulting from injury.

Joints are composed of two bones covered with articular cartilage, which allows the joint to glide, and ligaments, which hold the two bones together. Healthy articular cartilage and ligaments enable the bones to glide evenly over one another.

If the ligaments become weak, the bones will glide in an uneven manner. One area of the bone will bear additional weight on the articular cartilage when the joint is stressed. This uneven distribution of joint stress creates an even greater strain on the weakened ligament. Eventually all ligaments of the joint become lax and the joint becomes more and more unstable. As a result, articular cartilage breakdown occurs, causing a grinding or crunching noise when the joint is moved—as well as pain!

The above described process is not well understood in medicine. In one of the more recent papers on the true origins of knee osteoarthritis researchers made these observations:1

  • According to these researchers, thanks to new MRI techniques and arthroscopic surgery we have a better understanding of how knee osteoarthritis begins. For my opinion on these statements I invite the reader to review these articles on our website: Is My MRI Accurate? and Arthroscopic Knee Surgery for Osteoarthritis. In these articles you will find my comments on personal observations of misguided treatments based on MRI and unnecessary knee surgeries that accelerated the joint degeneration.
  • In their defense, the researchers of the above cited paper had this to say: “The significance of MRI findings such as cartilage defects, bone marrow lesions, synovial inflammation/effusions and meniscal tears in patients without radiographic signs of osteoarthritis is not fully understood. Nevertheless, early joint tissue changes are associated with symptoms and, in some cases, with progression of disease.”1 ibid

Twenty years ago, an article published in Gerontology disagreed with the notion that wear and tear is the origin of osteoarthritis and conducted a literary review to prove that osteoarthritis starts with ligament damage. Reviewing numerous research articles, the authors conclude that subchondral bone (the bone just beneath cartilage) changes precede any cartilage change associated with osteoarthritis.

These bone changes are due to a loss of tension on bone at the ligament/bone insertion. In other words, ligament laxity causes bone changes that in turn cause cartilage change and damage. Ligament laxity is due to ligament damage.

When discussing knee osteoarthritis, the authors point to the importance of joint stability in the development of osteoarthritis. All joints consist of a complex system of stability. The cascade of joint degeneration, however, begins with instability at the ligament site:  They state:

 “It should be remembered that the knee joint functions as an organ with every tissue contributing to its mechanical stability.  Ligaments, subchondral bone, menisci and joint capsule all subserve the need for stability. . . the earliest change appears to be at the ligament-bone insertions site.  However, we propose that it is a change in the ligament that leads to an alteration in the tension on the bone at the bone-insertion site which precipitates bone remodeling (injury to subchondral bone) [emphasis added].2

 Taking account of the progression of osteoarthritis, it becomes clear that the ligament integrity or lack of integrity is what needs to be treated to prevent further joint destruction and this applies to all joints:

“The health and integrity of the overlying articular cartilage depends on the mechanical properties of its bony bed.  Ligament injury precedes the subchondral bone changes and these changes occur before articular cartilage degeneration. ‘The proposed reversal of the current concepts of the aetiology of osteoarthritis from cartilage to bone and ligament suggests that research and therapeutic strategies could be effectively redirected.”2

That was twenty years ago and still pain management medicine continues to search for drugs, devices and surgical procedures to eliminate the chronic pain associated with osteoarthritis and degenerative joint disease and then fesses up that this is still not a fully understood science.

As mentioned above in the more recent paper: The standard osteoarthritis treatment involve symptom management such as nonsteroidal anti-inflammatory medications, cortisone shots and even surgery to provide pain relief. Cortisone and other steroid shots have adverse affects on bone, cartilage and soft tissue healing, this has been well documented, Unfortunately, many people suffering from chronic pain look for quick relief without thinking about the long-term, potentially harmful side effects that could occur. The problem with cortisone is that, although immediate pain relief is possible, it inhibits nearly every aspect of healing, making the pain condition worse.

The above are what I like to call “the anti-healing” treatments that can cause further degeneration of arthritic joints. The study above pointed out in 1997 the need for therapeutic strategies to be redirected. Since the etiology of osteoarthritis is ligament damage it would make sense to strengthen injured and lax ligaments.

The science behind joint repair

The body contains three different types of cartilage:

      • articular, which covers joint surfaces;
      • fibrocartilage, which is found in the knee meniscus and vertebral disk; and
      • elastic cartilage, which is found in the outer ear.

They are distinguished by structure, elasticity and strength. Cartilage is a complex, living tissue that lines the bony surface of joints. It provides shock absorption, enabling the joints to withstand weight bearing through the range of motion needed to perform daily activities as well as athletic endeavors. Articular cartilage damage is the most common type of cartilage damage, and can occur as a result either of injury or degeneration caused by wear and tear. Depending on the extent of the damage, and the location of the injury, articular cartilage cells may heal. However, articular cartilage has no direct blood supply, so it has little or no capacity to repair itself. If an injury penetrates the bone beneath the cartilage, the underlying bone provides some blood to the area, improving the chance of healing. This is one of the concepts behind microfracture surgery of the knee .

Regenerative Medicine for Treating Degenerative Joint Disease

The way to alleviate pain from degenerative joints is to stimulate ligament and cartilage repair with a Comprehensive Prolotherapy Approach. Please see our research articular cartilage repair in the Journal of Prolotherapy.

Osteoarthritis and degenerative joint disease involve the deterioration of the articular cartilage that lines the joints and related changes in adjacent bones and joints. This deterioration occurs because the supporting structures of the joints, primarily the ligaments, become injured . . . NOT because of general wear and tear on the joints or as an inevitable part of aging! Ligament injury is the culprit.

Progression of degenerative joint disease addressed by comprehensive Prolotherapy

  1. A ligament is damaged through overuse or trauma, such as a sports injury or an accident.
  2. Because of the ligament’s poor blood supply, it does not heal (unlike muscles, which have a good blood supply and heal quite easily).
  3. Over time, the injured ligament weakens, like a stretched rubber band that has lost its elasticity.
  4. Since ligaments function as joint stabilizers, the injured ligament is no longer capable of doing its job.
  5. As a result, the muscles must compensate. They begin to ache and spasm and, eventually, the joint or vertebra in the area begins to compensate as well.
  6. Overgrowth of bone occurs to help stabilize the injured ligament, which leads to arthritis, and a whole new level of pain and disability.

Stem Cells and Prolotherapy for degenerative joint disease

This downward spiral of pain can be halted and reversed only by stimulating healing at the source—the ligament. The only proven procedure that stimulates this kind of healing is Prolotherapy.

Recently we published our findings on Stem Cell Therapy, as part of a comprehensive Prolotherapy program for advanced arthritis. In this paper we were able to describe our experience with a simple, cost-effective regenerative treatment using direct injection of unfractionated whole bone marrow (stem cells from a patient’s own bone marrow), into osteoarthritic joints in combination with simple dextrose Prolotherapy. Seven patients with hip, knee or ankle osteoarthritis received two to seven treatments over a period of two to twelve months. All patients reported improvements with respect to pain, as well as gains in functionality and quality of life. Three patients, including two whose progress under other therapy had plateaued or reversed, achieved complete or near-complete symptomatic relief, and two additional patients achieved resumption of vigorous exercise. Learn more about stem cell therapy for osteoarthritis and Prolotherapy at pages on our website.

In my opinion and documented by scores of medical papers, Prolotherapy is the safest and most effective treatment for repairing tendon, ligament and cartilage damage is Prolotherapy. Prolotherapy stimulates the body to repair painful areas. It does so by inducing a mild inflammatory reaction in the weakened ligaments and cartilage. The inflammation causes the blood supply to dramatically increase in the ligament, alerting the body that healing needs to take place. In the simplest terms, Prolotherapy stimulates healing.

Furthermore, Prolotherapy offers the most curative results in treating osteoarthritis and degenerative joint disease. It effectively eliminates pain because it attacks the source: the fibro-osseous junction, an area rich in sensory nerves. What’s more, the tissue strengthening and pain relief stimulated by Prolotherapy is permanent!

1. Favero M, Ramonda R, Goldring MB, Goldring SR, Punzi L. Early knee osteoarthritis. RMD Open. 2015 Aug 15;1(Suppl 1):e000062. doi: 10.1136/rmdopen-2015-000062. eCollection 2015.

2. Bailey AJ, Mansell JP. Do subchondral bone changes exacerbate or precede articular cartilage destruction in osteoarthritis of the elderly? Gerontology 1997; 43:296-304.

 Do you have questions on degenerative joint disease

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