Caring Medical - Where the world comes for ProlotherapyTemporomandibular Joint Syndrome – TMJ


In this article Tim Speciale DO, discusses TMJ treatments including Prolotherapy and Stem Cell Therapy.

In recent research doctors have found a significant association between Temporomandibular Joint Syndrome, joint hypermobility syndrome and symptoms of anxiety.1

What does this mean? That problems of jaw pain (TMJ) may be an indication of a body wide problem with loose joints and further, joint hypermobility syndrome and TMJ may manifest themselves as a potential link to the neural bases of anxiety and related somatic symptoms (pain that causes major emotional distress) 2. What does this mean? TMJ is more than a physical problem related to the jaw.3

The temporomandibular joint

The temporomandibular joint connects the mandible (lower jaw) to the part of the skull known as the temporal bone. The joint allows the lower jaw to move in all directions so that the teeth can bite off and chew food efficiently.

Temporomandibular joint ( TMJ ) syndrome occurs when the joint, muscles and ligaments involved do not work together properly, resulting in pain.

Temporomandibular Joint Syndrome

Temporomandibular joint syndrome is caused by ligament weakness, often as a result of clenching the jaw or grinding the teeth, sleeping position or a forward positioned mandible (lower jaw). Malocclusion, or a poor bite, places stress on the muscles and may also lead to temporomandibular joint syndrome, as may an injury to the head, jaw or neck that causes displacement of the joint. If left untreated, osteoarthritis can result.

The head and neck pain associated with temporomandibular joint syndrome (TMJ) has received a myriad of traditional treatments, many of which involve surgery. They include:

The problem with any of these approaches is that they do not repair the weakened TMJ ligament and, thus, does not alleviate the chronic pain that people with this condition experience. And thus, most dentists and oral surgeons believe that TMJ cannot be cured and the best hope is for temporary symptom relief.

A standard practice is the use of steroids and anti-inflammatory medications. However, in the long run, these treatments do more damage than good. Cortisone shots and anti-inflammatory drugs have been shown to produce short-term pain benefit, but both result in long-term loss of function and even more chronic pain by actually inhibiting the healing process of soft tissues and accelerating cartilage degeneration.

Prolotherapy and Stem Cell Therapy for Temporomandibular Joint Pain and Dysfunction

New research suggests that stem cells are an exciting and extremely promising treatment in TMD and TMJ.

Doctors out of Singapore have just released their report on stem cell therapy for TMJ and TMD. Here are summary facts on their paper.

In the past decade, progress made in the development of stem cell-based therapies and tissue engineering have provided alternative methods to attenuate the disease symptoms and even replace the diseased tissue in the treatment of TMJ disorders.  This represents innovative approaches of cell-based therapeutics, tissue engineering and drug discovery in treatment.1 (Stem cells)

This supports earlier research which found

In Prolotherapy research, doctors say that they see appreciable improvements in the number of episodes of dislocation and clicking after Prolotherapy treatment.

In supportive research doctors say that they see appreciable improvements in the number of episodes of dislocation and clicking after Prolotherapy treatment.

In research published here at Caring Medical, our doctors reported on successful dextrose prolotherapy for patients with chronic neck pain. In this study, fourteen patients who suffered from TMJ pain for an average of 5.4 years and had seen, on average, four medical doctors—including half who were told that no other treatment options were available.

Overall, substantial improvements were reported in:

These improvements persisted through follow up at eighteen months after the conclusion of prolotherapy treatments.10

Prolotherapy is a safe and effective natural medicine treatment for repairing tendon, ligament and cartilage damage. In simple terms, Prolotherapy stimulates the body to repair painful areas. It does so by inducing a mild inflammatory reaction in the weakened ligaments and cartilage. Since the body heals by inflammation, Prolotherapy stimulates healing.

TMJ Contact

1. Chang TH, Yuh DY, Wu YT, Cheng WC, Lin FG, Shieh YS, Fu E, Huang RY. The association between temporomandibular disorders and joint hypermobility syndrome: a nationwide population-based study. Clin Oral Investig. 2015 Feb 17. [Epub ahead of print]

2. Mallorquí-Bagué N, et al . Emotion processing in joint hypermobility: A potential link to the neural bases of anxiety and related somatic symptoms in collagen anomalies. Eur Psychiatry. 2015 Feb 12. pii: S0924-9338(15)00048-6. doi: 10.1016/j.eurpsy.2015.01.004. [Epub ahead of print]

3. Reissmann DR, John MT, Seedorf H, Doering S, Schierz O. Temporomandibular disorder pain is related to the general disposition to be anxious.  J Oral Facial Pain Headache. 2014 Fall;28(4):322-30. doi: 10.11607/ofph.1277.

4. Hoffman D, Puig L. Complications of TMJ surgery. Oral Maxillofac Surg Clin North Am. 2015 Feb;27(1):109-24. doi: 10.1016/j.coms.2014.09.008.

5. Raphael KG, Tadinada A, Bradshaw JM, Janal MN, Sirois DA, Chan KC, Lurie AG. Osteopenic consequences of botulinum toxin injections in the masticatory muscles: a pilot study. J Oral Rehabil. 2014 Aug;41(8):555-63. doi: 10.1111/joor.12180. Epub 2014 May 17.

6. Zhang S1, Yap AU, Toh WS. Stem Cells for Temporomandibular Joint Repair and Regeneration. Stem Cell Rev. 2015 Jun 28. [Epub ahead of print]

7. Zhang J, Guo F, Mi J, Zhang Z. Periodontal ligament mesenchymal stromal cells increase proliferation and glycosaminoglycans formation of temporomandibular joint derived fibrochondrocytes. Biomed Res Int. 2014;2014:410167. doi: 10.1155/2014/410167. Epub 2014 Nov 10.

8. Zhou H, Hu K, Ding Y. Modified dextrose prolotherapy for recurrent temporomandibular joint dislocation. Br J Oral Maxillofac Surg. 2014 Jan;52(1):63-6. doi: 10.1016/j.bjoms.2013.08.018. Epub 2013 Sep 21.

9. Ungor C, Atasoy KT, Taskesen F, Cezairli B, Dayisoylu EH, Tosun E, Senel FC. Short-term Results of Prolotherapy in the Management of Temporomandibular Joint Dislocation. J Craniofac Surg. 2013 Mar;24(2):411-5. doi: 10.1097/SCS.0b013e31827ff14f.

10. Dextrose Prolotherapy and Pain of Chronic TMJ Dysfunction




How Can We Help You?
Contact Information:
First Name*:
Last Name*:
How did you hear about us?
Are you looking for more information on our specialties?
I am interested in ProlotherapyI am interested in Stem Cell TherapyI am interested in Platelet Rich PlasmaI am looking for a potential alternative to surgeryI am interested in Digital Motion X-ray in Florida
Tell us more about your case:
Current diagnoses by another healthcare provider:
My primary medical concern I would like to inquire about*:
My current level of athletics and/or daily activities
(ie: marathon training, manual labor, etc..):
I am interested in an appointment at this location:
Oak Park, IllinoisFort Myers, Florida
as soon as possiblewithin a couple weekswithin 1-2 monthsnot sure
Please leave this field empty.

for your symptoms

Prolotherapy, an alternative to surgery

Were you recommended SURGERY?
Get a 2nd opinion now!

★ ★ ★ ★ ★We pride ourselves on 5-Star Patient Service!Come see why patients travel from all
over the world to visit our clinics.
Current Patients
Become a New Patient

Chicagoland Office
715 Lake St., Suite 600
Oak Park, IL 60301
(708) 393-8266 Phone
(855) 779-1950 Fax
Southwest Florida Office
9738 Commerce Center Ct.
Fort Myers, FL 33908
(239) 303-4069 Phone
(855) 779-1950 Fax Fort Myers, FL Office
© 2017 | All Rights Reserved | Disclaimer
National Prolotherapy Centers specializing in Comprehensive Prolotherapy,
Stem Cell Therapy, and Platelet Rich Plasma.

Meet our Prolotherapy Doctors and check out our Prolotherapy research.