Achilles tendon repair | Surgical – Non Surgical | Prolotherapy PRP and Stem Cells
Danielle R. Steilen-Matias, MMS, PA-C discusses the use of Prolotherapy, PRP, and Stem Cells as non-surgical treatment for Achilles tendon degeneration and for partial ruptures and as adjunct treatment following complete achilles tendon rupture and surgery.
- If you have questions about the Non-surgical treatment of Achilles tendon injuries, get help and information from Caring Medical
What are we going to cover in this article?
- You have an injury to your achilles, whether acute or chronic problems, what are your options?
- A discussion on Comprehensive Prolotherapy, a non-surgical injection treatment that may include the use of Platelet Rich Plasma or possibly your own stem cells.
In 2016, Ross Hauser MD and I noted in our published review of Prolotherapy in the journal: Clinical Medicine Insights Arthritis and Musculoskeletal Disorders
“Consensus is growing regarding the efficacy of dextrose prolotherapy as an alternative to surgery for patients with chronic tendinopathy who have persistent pain despite appropriate rehabilitative exercise.”(1)
Prolotherapy and PRP introduction
Prolotherapy is regenerative injection technique that stimulates repair of injured tissue. We inject in around an achilles tear or degenerated tendon to create new healthy, regenerated tissue and get athletes and runners back to their activities.
Most people that we see in the office for achilles tendon tear or degeneration have not had success with typical treatments such as anti-inflammatories or standard immobilizing. People who do end up in our office for evaluation of achilles tendon degeneration and tears heel very well Prolotherapy. This is documented in the research below.
Sometimes we may have to differentiate the treatment based on the type of injury. We can inject dextrose into a degenerative tendon and regenerate tissue but if we’re trying to essentially glue back fibers from a more significant tear, we get healing factor cells from the patient. This would be platelet rich plasma or PRP cells which come from the patient’s own blood. These cells are injected into the tendon using ultrasound guidance. We may also recommend immobilization to the area. Immobilization is usually not ideal because tendons need motion to heal, however the exception to that is when we are putting PRP or Prolotherapy in the tendon and we are trying to heal that tendon from more significant damage, then immobilization is sometimes necessary.
Understanding Chronic achilles tendon injuries
Injury to the achilles tendon increases with age and overuse. That has been clearly and well documented in the medical literature. While age and overuse make athletes and active people predisposed to injury, many patients will come into our office and describe an onset of pain that can be traced to a new and sudden burst in activity (a new exercise program). In many cases this acute injury has occurred from chronic wear and tear – the tendon has finally tore sufficiently enough to be considered an acute injury.
- This can be especially true in runners who will report that they pulled their achilles or have a strained achilles. Achilles tendon injuries are especially susceptible in treadmill runners as reported in the The Journal of orthopaedic and sports physical therapy,(2) and people who run on sand as reported in the journal Sports Medicine.(3)
In chronic achilles tendon injuries patients will report:
- their heel and achilles tendon area feels sore and tender to the touch, with the soreness coming and going to varying degrees.
- some patients report a clicking and popping sound.
- some will show swelling and an enlargement of the achilles tendon. There may be bumps or nodules in the mid achilles region. A “stiff” achilles tendon or a sensation of tightness is also reported in patients who have difficulties pointing their toes upward.
- patients may have inflammation which may point to paratenonitis – an inflammation of the surrounding sheath, tendinitis with is inflammation of the tendon caused by wear and tear, and tendinosis, degeneration without inflammation.
Noninsertional Achilles Tendinitis and Insertional Achilles Tendinitis
- Noninsertional Achilles Tendinitis is where the tendon has begun to fray and breakdown in the middle of the achilles tendon. This is an injury more typical of active patients.
- Insertional Achilles Tendinitis occurs closer to the heel area where the achilles attaches or inserts itself to the heel bone.
In both conditions, the tendon seeks a way to stabilize itself and the heel-ankle complex area. It does so by calcifying (hardening) and by forming bone spurs on the heel.
Chronic Recalcitrant (Difficult to treat) Achilles Tendinopathies and Prevention of Achilles tendon rupture: Introducing Platelet Rich Plasma Therapy
In this section we will discuss treatment options. The first treatment option is Platelet Rich Plasma Therapy. Platelet Rich Plasma Therapy, is an autologous derivative of whole blood that contains a supraphysiological (a greater than normal amount) concentration of platelets. You can learn more about this treatment here What is Platelet Rich Plasma Therapy?
Doctors in China writing in the Journal of tissue engineering and regenerative medicine have made the case that platelet rich plasma injections awaken and stimulate native stem cells to repair achilles tendon damage. Here are the bullet points:
- The study’s purpose was to investigate whether platelet-rich plasma would activate tendon-derived stem cells to promote regeneration of Achilles tendon post-rupture in rats.
- In the in vitro study, platelet rich growth factors significantly enhanced cell DNA synthesis (cell replication) improved viability and promoted proliferation, while facilitating cell migration and the recruitment of tendon-derived stem cells.
- In other words, PRP promoted the creation and multiplication of stem cells.(4)
What does this mean to the patient?
- More evidence that PRP can non-surgically repair an achilles tendon in various degrees of rupture and tear.
In addition to the research cited above, another Italian research team evaluated the long-term clinical outcome in patients affected by mid-portion Chronic Recalcitrant Achilles Tendinopathies (CRAT) treated with administration of single platelet-rich plasma (PRP).
A total of 73 patients age 43 years old predominantly males had 83 tendons treated with a single PRP injection. They were then evaluated using standard scoring systems.
Here are their results
- 91.6% were rated as satisfactory and patients would repeat the treatment.
- 8.4% were classified as unsatisfactory at the 6 months follow-up and underwent a second PRP injection.
- In addition to this, patients reported no Achilles tendon rupture.
Therefore the conclusion: The use of a single PRP injection can therefore be a safe and attractive alternative in the treatment of non-insertional CRATs.(5)
Prolotherapy for achilles tear and tendinopathy
Researchers have shown the effectiveness and safety of Prolotherapy injections for management of lower limb tendinopathy and fasciopathy. In the Journal of Foot and Ankle Research
The doctors were looking to identify and evaluate existing research to determine the clinical effectiveness and safety of Prolotherapy injections for treatment of lower limb tendinopathy and fasciopathy.
- Results of the analysis provide support for Prolotherapy as an effective treatment in both reducing pain and improving function in tendinopathy and fasciopathy.
- The analysis also suggests Prolotherapy injections provided equal or superior short-, intermediate- and long-term results to alternative treatment modalities, including eccentric loading exercises for Achilles tendinopathy, platelet-rich plasma for plantar fasciopathy and usual care or lignocaine injections for Osgood-Schlatter disease. No adverse events following prolotherapy injections were reported in any study in this review.(6)
In an April 2017 study, doctors writing in the Scandinavian journal of medicine and science in sports reported positive results in 12 of 13 research studies for achieving pain relief and patient satisfaction for patient’s receiving Prolotherapy on chronic painful achilles tendinopathy.(7)
Prolotherapy shows significant clinical results in study
Researchers from London Independent Hospital and Queen Mary University of London examined intra-tendinous achilles tear (A tear within the tendon). They also examined Prolotherapy as a treatment for this tear, which they write “involves injecting an irritant, such as hyperosmolar dextrose, to stimulate a tissue healing response and ultimately reduce pain.”
In their study, 43 patients with an intra-tendinous tear were given Prolotherapy injections A 4-6 week period of walking boot immobilization was followed by progressive rehabilitation (6-8 weeks).
- 30 patients (70%) responded with VISA-A scores (A scoring system to measure achilles tendon pain) showing significant healing after 3 months and even more so at 12 months. Showing long-lasting results.
- After 5 months, 27% of tears were no longer detectable in imagining.
- Treatment resulted in clinically significant improvements.(8)
Prolotherapy researcher John Lyftogt MD reported positive results in two studies published in the Australian Musculoskeletal Medicine Journal, for chronic Achilles tendinopathy (average length of symptoms two years) with subcutaneous dextrose Prolotherapy.(9,10)
In 2007, Canadian researchers published a study on the use of hyperosmolar dextrose prolotherapy (25%) to treat 32 patients representing 33 tendons with chronic tendinosis of the Achilles. At an average of 12 months after treatment, 20 patients remained symptom free, nine experienced only mild symptoms, and one patient reported moderate symptoms. (11)
This was supported by research published in 2010 which showed the results of Prolotherapy in 99 patients with long-term pain related to the Achilles tendon. Patients received an average of five injection sessions spaced on average 5.6 weeks apart. A statistically significant improvement in pain scores was observed for both midportion and insertional in mean percent reduction in pain at 28 month follow-up. (12)
This research supported that of a paper published in 2009 that Prolotherapy and eccentric loading exercises for painful Achilles Tendon provided great improvements in the patient’s condition. (13)
For patients who have already received steroid injections or surgery for Achilles tendinopathy, but still have pain, Prolotherapy and Platelet Rich Plasma Injections may be a good regenerative treatment to consider to improve the entire heel, achilles, ankle complex, especially with tight achilles tendon pain that may be causing Equinus a condition that limits the motion of the ankle.
Stem Cell Prolotherapy | Stem cells repair achilles tendon damage
When there is advanced tearing or more damage to the achilles tendon, in addition to PRP discussed above, stem cell therapy may be introduced.
Researchers in South Korea also examined adipose stem cell therapy in a new study from March 2017. Writing in the American journal of sports medicine, the Korean doctors found:
- In tendon injury, Human Adipose-Derived Mesenchymal Stem Cells can enhance tendon healing by secreting their own protein and have potential as a therapeutic option in human tendinopathy.(14)
- Also from March 2017, Italian researchers found PRP and adipose-derived mesenchymal stem cells to be effective treatments for difficult to treat Achilles tendinopathy. These treatments should be taken into consideration for those patients who require an earlier return to daily activities or sport.(15)
Ruptured Achilles Tendon
Achilles tendon ruptures can take on many types. There can be a partial rupture or a complete rupture. The Achilles with a rupture can still be intact – it could also be “totally gone.”
Doctors writing in the medical journal Lancet examined the use of Platelet Rich Plasma Therapy for patients with a ruptured Achilles tendon.
- Twenty patients with a ruptured Achilles tendon had tendon tissue samples taken. Ten of the patients had PRP, ten patients had placebo treatments.
The findings reveal that locally applied PRP accelerated healing based on cellularity (the number of cells) and glycosaminoglycans (an amino sugar in hyaluronic acid or chondroitin sulfate useful in healing) content were significantly higher in PRP-treated tendons than in controls.(16)
Realistic expectation of stem cells and platelet-rich plasma treatments and a ruptured achilles tendon
Stem cell therapy is the injection of stem cells into the damaged achilles tendon. You can learn more about the treatment here What is Stem Cell Therapy?
In recent research, and as mentioned in the above citations, doctors in Turkey, bone marrow derived stem cells (MSCs these are stem cells taken in a simple aspiration procedure from the iliac crest of the pelvis or from abdominal fat) promoted the recovery of the ruptured achilles tendon and increase its structural strength.
The doctors concluded:
- “The use of PRP and MSCs provides hope for the treatment of Achilles tendon ruptures that limit human beings’ functionalities and quality of life, particularly for athletes. It is thought that the use of MSC can be more effective for tendon healing.”(17)
Treatment following Achilles Tendon Surgery
Spanish researchers writing in the medical journal Knee surgery, sports traumatology, arthroscopy used animal models to examine the biomechanical effects of intra-tendinous injections of Platelet Rich Growth Factors on the healing Achilles tendon after surgical repair. The researchers found that Platelet Rich Growth Factors increased Achilles tendon repair strength at eight weeks compared with the use of placebo.(18)
There have been numerous studies testing the validity of use of Platelet Rich Plasma during open surgery. These studies have lead some to question whether or not PRP can help with post-surgical rehabilitation if applied at the time of surgery.
- Doctors in Italy wrote in a July 2016 paper: “The addition of PRP to the surgical treatment of Achilles tendon rupture does not appear to offer superior clinical and functional results.”(19)
One of the big problems with studies on PRP or stem cell enhancements at the time of surgery is the problem of dilution.(20) In our article on Arthroscopic knee surgery for osteoarthritis I came upon a study that found that during surgery, surgical dyes, irrigation fluids, and other liquids forced into the repair area significantly diluted healing agents during surgery and more importantly post-surgery.
So theoretically, we are asking a weakened PRP treatment to heal surgical damage
However, doctors writing in the medical journal Foot and Ankle Specialists said:
Treatment protocols with PRP have been performed in 2 ways- administered adjunctively during tendon surgery and as a stand-alone injection (please see our article What is Platelet Rich Plasma Therapy?)
The senior researcher had utilized PRP by both methods to treat Achilles tendinopathy over a 7 year period. Twenty six patients were followed, half having undergone Achilles tendon surgery in combination with PRP administration and the other half PRP injections alone.
Both the stand-alone injection group and surgical/injection groups had statistically significant degrees of improvement in pre-MRI and post-MRI imaging studies. There was no statistically significant difference between the 2 treatment groups.(21)
PRP did help in surgery and helped equally without surgery. This is why seeking a consultation with a doctor experienced in the varied PRP, stem cells, and a comprehensive Prolotherapy approaches can offer the patient more options pre and post surgery for enhanced and accelerated achilles repair.
One note on immobilization
In stark contradiction to the Rice, Ice, Compress, Elevate theory in managing post surgical treatment, doctors in August of 2016 published their research that functional weight-bearing mobilization enhanced the early healing response of achilles tendon recovery. In addition, early ankle range of motion was improved without the risk of Achilles tendon elongation (laxity and instability) and without altering long-term functional outcome.(22)
In this article we have shown that Prolotherapy, PRP PRolotherapy and Stem Cell Prolotherapy can be viable options for your Achillies tendon problems. If you have questions, send it to our staff
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