Are you a candidate for stem cells?

Danielle.Steilen.ProlotherapistDanielle R. Steilen-Matias, MMS, PA-C

Stem Cell research is part of a new medicine that is evolving from treating symptoms to fixing a problem. This evolution is discussed in numerous studies.

Before you read on, if you have questions about Stem Cell Therapy, get help and information from our Caring Medical staff

A multinational team including American researchers published their findings in late 2016:

Growth factors, blood derivatives, such as platelet concentrates, and mesenchymal adult stem cells, either expanded or freshly isolated, are advocated amongst the most promising tool for the treatment of osteoarthritis, especially in the early phases.

Primarily targeted towards focal cartilage defects, these biological agents have indeed recently showed promising results to relieve pain and reduce inflammation in patients with more advanced osteoarthritis as well, with the final aim to halt the progression of the disease and the need for joint replacement.1

Clearly stated in this research is the end goal of stem cell therapy –
to avoid the need of joint replacement.

Stem cell injection therapy can be used to treat chronic pain, severely degenerated joints such as the knee, hip, and shoulder, as well as soft tissue tears in the hip labrum and shoulder labrum, meniscus, and ACL of the knee.

In a second study doctors had this to say: “Treatment options for muscle, tendon, and ligament injuries span a constantly evolving spectrum. For years, treatments focused on symptomatic relief. Closer scrutiny of symptomatic treatment suggests that the provision of transient relief of symptoms (Cortisone, NSAIDs, anti-inflammatory medications) may have caused more harm than good.

Cortisone injections provide a trade-off of short-term relief for poorer long-term outcomes. When conventional treatment failed, patients have faced limited options including surgery, which has increased risk and limited efficacy.”2

The investigators continued “Regenerative injections (stem cell therapy and Platelet Rich Plasma) offer a more robust option for soft tissue disease. “2

At Caring Medical we are not unique in agreeing that non-operative treatments to control pain symptoms including:Anti-inflammatory medications, viscosupplementation, bracing, orthotics and activity modification along with classical surgical techniques for articular cartilage lesions are frequently insufficient in restoring normal anatomy and function and in many cases, it has not been possible to achieve the desired results.

Our clinical observations have agreed with numerous studies that have appeared in the last few months that suggest stem cell injections provide a permanent biological solution.

Mesenchymal stem cells (MSCs) isolated from bone marrow and adipose tissue show considerable promise for use in cartilage repair. The MSCs can modulate the immune response. Additionally, MSCs can directly differentiate into chondrocytes under appropriate signal transduction. They also have immunosuppressive and anti-inflammatory paracrine effects.3

The stem cells work by making the immune system respond through various means to rebuild cartilage and bone – please see our article on Stem Cell Therapy for bone repair in osteoarthritis for a detailed discussion on how stem cells regrow and repair damaged bone by “signaling.”

Doctors reported that additional studies on stem cell therapy for rebuilding cartilage continued to confirm that  stem cells present an attractive treatment option for articular cartilage repair. They cite the recent expansion of clinical trials investigating their use in patients. 4

In recent research doctors addressed the problems of  articular cartilage damage and degeneration in joints. Treatment of cartilage tears are a challenge because cartilage is incapable of quality repair and/or regeneration to its native state, stem cells and Prolotherapy have answered that challenge.

Here are more citations to support stem cells for cartilage preservation and repair. Recently, cell-based therapy has become a key focus of tissue engineering research to achieve functional replacement of articular cartilage.5

More research

Are you a candidate for stem cell therapy?

Stem Cell Therapy or Stem Cell Prolotherapy (SCP) is the utilization of stem cells from bone marrow and fat tissue (adipose) to stimulate damaged tissues such as cartilage, (cartilage repair) ligaments, tendons, meniscus and labrum to repair.

Dextrose Prolotherapy stimulates the cells that are present in the damaged area to proliferate. However, sometimes there is a deficiency of cells or not enough building blocks to rebuild a joint, such as in osteoarthritis or tendinosis and one needs to provide additional cells for healing. Stem Cell Therapy injections provides the new material in the joint. It provides immune cells and stem cells (and other progenitor cells) that can change into healing cells and fibroblasts to make collagen for ligaments and tendons.

The conditions that stem cell therapy can be best for include bone on bone arthritis or osteochondral defects, Chondromalacia Patella, avascular necrosis, tendinosis, and other conditions.

Researchers also stress that not all doctors perform stem cell therapy in the same way and that the potential candidate for the treatment should be advised.

Please see the following articles on our website for more research on stem cells:

Please see our discussions in the medical journal Clinical medicine insights. Arthritis and musculoskeletal disorders where our team presented three difficult knee pain case histories treated with Bone Marrow Stem Cell Aspirate.

If you have questions about Stem Cell Therapy, get help and information from our Caring Medical staff

1. de Girolamo L, Kon E, Filardo G, Marmotti AG, Soler F, Peretti GM, Vannini F, Madry H, Chubinskaya S. Regenerative approaches for the treatment of early osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2016 Apr 27. [Epub ahead of print] Review. [Pubmed]
2. Mautner K, Blazuk J.Where do injectable stem cell treatments apply in treatment of muscle, tendon, and ligament injuries? PM R. 2015 Apr;7(4 Suppl):S33-40. doi: 10.1016/j.pmrj.2014.12.012.[Pubmed]
3. Chang YH, Liu HW, Wu KC, Ding DC. Mesenchymal Stem Cells and their Clinical Applications in Osteoarthritis. Cell Transplant. 2015 Dec 18. [Pubmed]
4. Mazor M, Lespessailles E, Coursier R, et al. Mesenchymal stem-cell potential in cartilage repair: an update. J Cell Mol Med. 2014 Oct 29. doi: 10.1111/jcmm.12378. [Pubmed]
5. Reissis D, Tang QO, Cooper NC, Carasco CF, Gamie Z, Mantalaris A, Tsiridis E. Current clinical evidence for the use of mesenchymal stem cells in articular cartilage repair. Expert Opin Biol Ther. 2016 Jan 22. [Pubmed]
6. Diekman BO, Guilak F. Stem cell-based therapies for osteoarthritis: challenges and opportunities. Curr Opin Rheumatol. 2013 Jan;25(1):119-26. doi: 10.1097/BOR.0b013e32835aa28d. [Pubmed]
7. Hauser RA, Orlofsky A. Regenerative injection therapy with whole bone marrow aspirate for degenerative joint disease: a case series. Clin Med Insights Arthritis Musculoskelet Disord. 2013 Sep 4;6:65-72. doi: 10.4137/CMAMD.S10951. eCollection 2013. [Pubmed]

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