Is treating avascular necrosis of the femoral head without hip replacement possible?

Ross A. Hauser, MD.

Treating avascular necrosis of the femoral head without hip replacement

Many patients we see with AVN or Avascular necrosis of the femoral head in the hip joint understand their problem as “dead bone,” or “dead bone from lack of blood supply,” and for the most part, that is what the problem is the dead or dying bone that can lead to eventual hip collapse. The term some of these patients also use is “Osteonecrosis” which also means “dead or dying bone.”

Osteonecrosis, avascular necrosis, AVN, or aseptic necrosis (as this is diagnosed under many names), is a condition where the blood supply to the bone is impeded or disrupted. Bone needs circulating blood to regenerate and repair itself so you can have pain-free, healthy joint motion. Loss of blood flow to the hip is a leading cause of hip degenerative disease and the need for hip replacement surgery. Without blood flow, the bone undergoes wear and tear without the ability to repair the degenerative damage. Eventually, your bone dies, the femoral head (the ball) of the hip joint collapses, and in essence, your hip dies with it.

To avoid this outcome, especially in patients who are deemed too young for total hip replacement, one treatment option that your doctors may have discussed with you in treating your avascular necrosis is core decompression surgery.

Discussion points of this article:

The caption of this image reads: AP or front view x-ray of pelvis. Example of a patient whose x-ray shows a completely destroyed hip compared to a nearly normal hip on the other side. This person was referred for a hip replacement. In this image we also see a collapse of the femoral head. Not all patients will be able to avoid a hip replacement if the are in advanced avascular necrosis.

Caring Medical Research: Avascular Necrosis Case Report of Direct Bone Marrow Injections and Prolotherapy Treatment

When we first began publishing research on our results with bone marrow injections, we were able to show a patient case history of the repair of avascular necrosis of the talus (the large bone of the ankle). Later and documented below, we showed the results in cases of advanced hip degeneration.

Back to the ankle patient briefly and writing in the Journal of Prolotherapy, we documented the first case report of using direct bone marrow aspiration into areas of pain in a patient with avascular necrosis of the talus that did not involve core decompression. In this particular case, the bone marrow aspirate was injected into the tibiotalar and subtalar joints. The surrounding painful and injured ligaments on the lateral and medial sides of the ankle were also treated with Prolotherapy. Treating avascular necrosis with bone marrow stem cells is definitely a viable and successful treatment option to explore prior to surgery. (16 Read our research)

In our research published medical journal Clinical Medicine Insights Arthritis and Musculoskeletal Disorders (17), Ross Hauser, MD we documented the following cases of advancing hip osteoarthritis. As of this article update August 4, 2022, this paper has been cited by 24 other papers listed at PubMed Central® at the U.S. National Institutes of Health’s National Library of Medicine and 81 papers listed in Google Scholar. Below are case histories from our research.

Patient case: A 76-year-old female

A 76-year-old female came into our office with pain in both hips that had plagued her for the last 3-4 years. Her left hip pain was more significant than the right. She was unable to walk more than a mile without significant pain. The patient had received a recommendation for hip replacement. X-rays revealed moderate to severe degenerative changes in both hips.

The patient received seven bone marrow/dextrose H3 Prolotherapy treatments to each hip over a period of 12 months and adhered to a program of daily bicycle exercise.

Patient case: – A 56-year-old female presented with pain in bilateral knees and right hip.

Patient case: A 63-year-old male presented with bilateral hip pain.

In this research we concluded:

“We have explored whole bone marrow injection in combination with dextrose Prolotherapy is a cost-effective approach with potentially broad application for osteoarthritis. . .Our initial experience has been encouraging, as all patients experienced significant gains in treatment periods of 2–12 months without adverse events.

Additionally, five of seven patients experienced strong functional improvement and/or complete or near-complete pain relief. Patients uniformly expressed satisfaction with outcomes in interviews.

Five patients reported receiving a previous recommendation for joint replacement, and at the final interview, none believed replacement would be needed. 

Among the papers citing our work, a December 2018 paper in the publication PM & R: the journal of injury, function, and rehabilitation (32) found “intra-articular injections of bone marrow concentrate for the treatment of early knee or hip osteoarthritis were safe and demonstrated satisfactory results in 63.2% of patients. Future studies are necessary to determine the efficacy of this technique and its safety profile.”

Avascular necrosis, or bone death, is an example of a condition that may be due to joint instability or may be due to lifestyle or medication.

Avascular necrosis, or bone death, is an example of a condition that may be due to joint instability or may be due to lifestyle or medication. There are two reasons why someone develops avascular necrosis: a systemic problem or joint instability. The bone can die due to large doses of medications needed to treat certain systemic conditions, such as chemotherapy or prednisone. Or, avascular necrosis can occur in cases of excessive alcohol use.

Understanding the hip ligaments, joint instability and bone death

Summary: AVN signifies bone cell and tissue death; ligamentosis means ligament cell and tissue death; tendinosis described degeneration and death of tendon cells; degenerated hip meniscus denotes meniscus cell and tissue death; degeneration of the labrum indicates labral cell and tissue death; and finally bone-on-bone means articular cartilage tissue and cell death. Simply put, all these terms mean ‘cell and tissue death’. In hips with ligament injury and resultant hip instability, as the instability progresses, the tissues in and around the hip will continue to degenerate and die. As the tissues get weaker, their shock absorbing properties or their ability to diffuse pressure reduces so that the pressure with walking and standing gets concentrated on small sections of the femoral head and acetabulum. Eventually, femoral head collapse can occur.

In the image below we see how ligaments wrap around the ball and socket of the hip.

Very often people develop avascular necrosis due to joint instability since avascular necrosis occurs at the end of the bone which is the same place where the ligaments attach. Ligaments hold joints together and in their place. When ligaments, the bone to bone attachments are damaged or weakened, they no longer hold the bones in place and the bones begin to wander. Excessive rubbing of the ball of the hip in the socket of the hip by these wandering out of place bones can interrupt the blood supply. After continued pressure, bone can die. Therefore, avascular necrosis can be yet another MRI finding that really indicates that the person’s pain is coming from joint instability. Regenerative medicine injections can be a good option for these cases.

Are the ligaments the factor between symptomatic and asymptomatic AVN patients?

There are people with asymptomatic AVN and those with terrible hip pain with AVN. Wouldn’t the death of the bone and cartilage always be painful? Not necessarily. There no nerve endings in cartilage. The nerve endings that provide the majority of the pain signals in joints, including the hip joint, are in the hip capsular ligaments and the extracapsular ligaments. Thus, the only difference between asymptomatic and symptomatic AVN may be how much stretch is on the nerve endings in those structures.

The person with a physically demanding job and high-level competitive athlete.

Many people that contact us write because they are high-level athletes. They write to us that their hip pain became more than they could handle on their own. An MRI revealed avascular necrosis, and the first thing they heard from the doctor was: “You must stop running.” When they asked the doctor how did they get that way, the doctor answers, “your history of high-level sports is most likely.” Then the doctor may have already asked about how many times they were treated with high-dose corticosteroids, such as prednisone. As we see in the research, cortisone injections are a concerning cause of avascular necrosis. The same story can be heard in the people who work in restaurants or are landscapers or in construction. They write to us that work is becoming increasingly difficult. Unlike the athlete who can stop running, this person cannot stop working.

Cortisone

There is a great debate in the medical community in regard to the use of corticosteroid for varying health conditions and the accelerated development of hip osteoarthritis in the form of avascular necrosis leading to femoral head collapse. Let’s start looking at some studies.

First, the side that says corticosteroid does NOT appear to cause avascular necrosis. This is an October 2021 study in the Orthopaedic journal of sports medicine.(28)

“Recent studies have suggested there is an increased risk of avascular necrosis (AVN), subchondral insufficiency fracture, femoral head collapse, and osteoarthritis progression in the 12-month period after hip corticosteroid/anesthetic injection; however, these studies have failed to account for pre-injection osteoarthritis severity or preexisting avascular necrosis/ subchondral insufficiency fracture.”

What the researchers are getting at is the “pre-existing condition” of the hip and whether accelerated degeneration of the hip was caused by steroid injections or was simply the natural progression of a pre-existing disease. To determine this one group of patients who had a cortisone injection was matched to another group with similar characteristics for age, sex, level of hip degeneration who did not get a cortisone injection.

What were the findings?

The researchers said they did not find similar conclusions that cortisone caused an accelerated hip degeneration: They write: “In contrast to the findings of recent retrospective investigations, we did not find that patients treated with hip cortisone had significantly higher rates of short-term osteoarthritis progression or femoral head articular surface collapse after controlling for baseline osteoarthritis severity and preexisting avascular necrosis or subchondral insufficiency fracture.”

What the researchers said – “In contrast to the findings of recent retrospective investigations” was the acknowledgement that there is another side to this story.

“Intra-articular steroid injection can cause femoral head AVN, and the patient receiving these injections should be aware about this rare but significant complication that results in poor functional outcome and significant morbidity.”

A February 2020 study in the European journal of orthopaedic surgery & traumatology (29) suggested something for different. This research examined the single injection of cortisone as a cause of accelerated hip osteoarthritis and avascular necrosis.

“Long-term steroid intake was established as a cause of avascular necrosis. . .  We review(ed) all cases of avascular necrosis that results from single intra-articular steroid injection and present a case of femoral head AVN developed in a 78-year-old male. The patient, who was not known to have any medical illness, presented complaining of mild left hip pain for 4 months with long distant ambulation (walking) and weight standing. He was diagnosed to have left hip joint osteoarthritis for which he received intra-articular steroid injection two months prior visiting our orthopedics center. MRI of the pelvis revealed AVN of the femoral head. He underwent total hip arthroplasty. The pathological examination confirmed the diagnosis of AVN. To best of our knowledge, this is the fifth case of AVN of femoral head AVN after single intra-articular steroid injection. . . Intra-articular steroid injection can cause femoral head AVN, and the patient receiving these injections should be aware about this rare but significant complication that results in poor functional outcome and significant morbidity.”

An April 2020 paper in the American journal of physical medicine and rehabilitation (30) similarly recorded a case:

“(the case is presented of) osteonecrosis of the femoral head (which) developed in temporal association with a single intra-articular injection of corticosteroid (triamcinolone acetonide) in a 72-yr-old woman, resulting in a total hip arthroplasty. We conclude that the risk of developing osteonecrosis after a single intra-articular injection of corticosteroid needs to be considered in the informed consent process.”

Fewer hip intra-articular corticosteroid injections, less femoral head collapse

A November 2021 study (33)  lead by the University of Minnesota found that “Femoral head collapse is a rarely reported complication of hip intra-articular corticosteroid injection.” To address this concern, the researchers examined patients receiving hip intra-articular corticosteroid injection during a 27-month period to determine the rate of femoral head collapse and to identify associated patient factors or practice shortfalls.

“Long-covid” cortisone injections and avascular necrosis

An new phenomena is what doctors see as an epidemic of formal head collapse and the need for hip replacements. In a July 2021 paper in the journal  BMJ case reports researchers suggested: (31)

“By large-scale use of life-saving corticosteroids in COVID-19 cases, we anticipate that there will be a resurgence of avascular necrosis cases. We report a series of three cases in which patients developed avascular necrosis of the femoral head after being treated for COVID-19 infection. The mean dose of prednisolone used in these cases was 758 mg (400-1250 mg), which is less than the mean cumulative dose of around 2000 mg steroid, documented in the literature as causative for avascular necrosis. Patients were symptomatic and developed early avascular necrosis presentation at an average of 58 days after COVID-19 diagnosis as compared with the literature which shows that it generally takes 6 months to 1 year to develop avascular necrosis post steroid exposure.”

Indian doctors working with COVID-19 patients published an April 2022 report (37) on patients diagnosed with osteonecrosis of femoral head following recovery from COVID-19 disease. They found in 22 consecutive patients (17 both hips 5 one hip) who had recovered from COVID-19 received corticosteroids as a supportive treatment during COVID-19. Patients were classified into two types, those with classic osteonecrosis of femoral head and rapidly destructive coxarthrosis (the breakdown of cartilage and bone). What caused the rapidly destructive coxarthrosis? The researchers suggest: “low cumulative dose of steroids in our patients suggests that the COVID-19-associated vasculitis may play a role in the pathogenesis of osteonecrosis of femoral head.”

Treating hip pain and necrosis – core decompression or non-surgical injection therapy?

If you are reading this page it is likely that you have already received the recommendation to go ahead with a core decompression surgery. You may even feel that you got some good news in that your femoral head has not collapsed yet and you do not need a hip replacement. The recommendation to core decompression, while still major surgery, has its appeal. There is a chance that the core decompression surgery will save your hip, you will not need a much larger hip replacement surgery in the near future, and more importantly, you can have restored function and a lot less pain, faster. Or so is the belief.

If you are reading this page you have been researching and you have found some things that may offer you some concern about this procedure.

Please note that many people have core decompression surgery and do very well with it. Some do not. If you are reading this page, you are likely concerned about the problems that post-surgery patients had, or worse, you are one of those post-surgical people who have more pain after the procedure and are waiting for a hip replacement and your doctors are trying to figure out how to do it. You may be reading our article because you are looking for options, and we will present those below.

Core decompression – the surgery – bringing blood back to the bone

If you have been diagnosed with avascular necrosis of the hip, sometimes surgery is needed. If you have some reasonable range of motion remaining, for instance, a 50% or greater normal range of motion, then regenerative medicine injections may help with the pain and exercises like cycling and swimming and this can slowly allow the patient to regain some of the lost range of motion.

Core decompression is considered a “joint sparing” surgery. If it works, a hip replacement can be avoided or delayed. The core decompression surgical procedure involves drilling a hole(s) into the femoral head of the hip to relieve pressure (from bone edema/swelling) in the bone and hopefully create new blood vessels to nourish the affected areas of the hip. The hope is that the new blood circulation will help with bone rebuilding.

According to surgeons who perform this procedure: The overall success of this treatment is unclear.

The failure of core decompression to provide long-term relief has been a challenge for hip surgeons

Early in 2019, United States Army surgeons wrote of the “Low Rate of Return to Impact Activity Following Core Decompression for Femoral Head AVN in Military Service members.” (1) This study was published in the journal Military Medicine. Here is what the army doctors wrote:

Osteonecrosis is a multifactorial condition that can be caused by many things. This prevents surgeons from developing a single, standardized surgical treatment.

In August 2018, doctors at the Institute of Orthopedics and Traumatology at the University of San Paulo in Brazil published their findings in The Brazilian Journal of Orthopedics (2) Which questioned the success of core decompression surgery. These are the learning points:

The surgeon/researchers point out that their study was aimed at analyzing the characteristics of patients who underwent decompression in the last two years; all procedures were performed in the same way (guidewire placement in the femoral neck with fluoroscopic aid and drilling with a cannulated burr in the necrotic area).

Drilling relieved pressure and pain

Pain relief did not last long

Pain relief did not last long despite new techniques and innovative solutions

The researchers noted that the failure of core decompression to provide long-term relief has been a challenge for hip surgeons, who have used new techniques associated with core decompression, such as the use of vascularized or non vascularized grafts, stem cell injection, shock wave therapy, and anticoagulant drugs. Moreover, various techniques have been described using different types of drills and drillings. The results have been similar, with initial symptom improvement that does not influence disease progression.

The same research team published an updated article in June 2022 confirming (34) “Osteonecrosis of the femoral head has several therapeutic options in its early stages, all for symptom relief, and in an attempt to preserve the joint. . . In advanced cases, osteotomies (surgery to reshape the bone) are an option, and total femoral arthroplasty (a salvage operation after failed hip replacement that replaces the thigh bone) has excellent results, and the procedure should be individualized for each patient.”

“Core decompression provides only short-term clinical improvement”

Similar results were also seen in a March 2021 report published in the journal International Orthopaedics (3). In this paper from a team of international specialists from  Balgrist University Hospita in Switzerland, Cambridge University Hospitals in the United Kingdom, Meir Medical Center in Israel, and Harvard Medical School, the researchers wrote:

“Our study shows that core decompression provides only short-term clinical improvement and partial or complete pain relief in most of the cases (33 out of 37 studies reported postoperative clinical improvement). It should however be noted that reduction of pain may be due to temporary reduction of weight-bearing during the rehabilitation phase and further trials evaluating this aspect are necessary.

Our results also demonstrate that approximately 38% of patients underwent a total hip replacement at an average of 26 months following core decompression without augmentation (a patch or biological scaffold) in a large and diverse population with AVN of the femoral head of varied etiology. This review, however, could not determine whether core decompression alone can arrest disease progression due to lack of stratification and heterogeneity of data. (The evidence was not clear).

Extracorporeal shock wave therapy: maybe better than surgery?

An August 2022 paper published in The Physician and sports medicine (36) sought to determine whether ESWT (extracorporeal shock wave therapy) affects ONFH (osteonecrosis of femoral head) in clinical outcomes and radiography outcomes.

To do this, researchers examined nine previously published studies with 409 patients. The pooled results  showed improvements in 337 hips. The researchers concluded: “ESWT has an effect on pain relief and has a limited effect on motion function. Its effect may be better than surgical groups (core decompression and core decompression with bone grafting). But it cannot decrease the lesion area of the femoral head on MRI and stop disease progression.”

The failure of core decompression presents a challenge for hip surgeons in converting the hip to total hip replacement

In this section, we will present the research from the surgeons themselves in the challenges they face with a hip that has already had and failed core compression.

There is a problem with the rods and the metal debris in the hip they may cause.

A research team from Canada and the United Kingdom issued troubling findings in patients where core decompression failed and a subsequent total hip replacement was required.

The doctors, writing in the Bone and Joint Journal, (4) looked at core decompression and insertion of a tantalum rod into the hip joint for stabilization. The doctors were concerned that there may be a high failure rate associated with this procedure and examined failed tantalum rod insertion patients and their move to and subsequent hip replacement outcomes.

An August 2018 study in the journal BioMed Central Musculoskeletal Disorders (5) made similar findings.

“The mid-term clinical outcome of patients who underwent total hip replacement with tantalum rod implantation was not different from those without a tantalum rod, suggesting that tantalum debris did not increase the liner wear rate. However, the distribution of periprosthetic tantalum debris in the proximal, middle, and distal femoral regions may increase the risk of femoral osteolysis (the accelerated degeneration of the hip bone) and radiolucent lines (an indication of fracture. In Hip replacement or resurfacing it is an indication of implant loosening).

Common sense should tell us floating metallic debris in the hip is not optimum and reminds many of the metal on metal hip replacement recalls.

University hospital researchers in China writing in the journal International Orthopaedics (6) shared their equal concerns: “Porous tantalum osteonecrosis implants have been used in femoral head necrosis for several years, while the clinical outcomes were mixed. As a joint-preserving surgery, early necrosis deterioration and conversion to total hip replacement failed our expectation.”

What concerned the Chinese researchers was that the deterioration of early failed tantalum implants exceeds the nature of osteonecrosis progression. In other words, the implant caused accelerated hip degeneration.

They note that it was not the failure of the implant mechanical support, but rather the results of the drill that compromised the bone and led to the early failure of porous tantalum osteonecrosis implants.

In other words, the concern of the Chinese researchers was how fast the surgery failed and caused stress fractures in the bone it was designed to preserve.

 

American Academy of Orthopaedic Surgeons Illustration of Core decompression. (Right) In this x-ray, the drill lines show the pathway of small drill holes used in a core decompression procedure.

American Academy of Orthopaedic Surgeons Illustration of (Left) Core decompression.
(Right) In this x-ray, the drill lines show the pathway of small drill holes used in a core decompression procedure.

Porous tantalum osteonecrosis implants

Porous tantalum osteonecrosis implants


An October 2021 paper in the journal BioMed Central surgery (7) evaluated the survival rate of porous tantalum rod implantation in the treatment of osteonecrosis of the femoral head. In 52 hips that received the implants, 24 hips had to be sent to total hip replacement (46.2%), the average time was about 44 months from implant to replacement.

Making core decompression work better – a better drill?

Doctors in Germany examined “Advanced Core Decompression,” a new option that tries to remove the necrotic (dead) tissue in patients with osteonecrosis of the femoral head in a minimally invasive way by the use of a percutaneous expandable reamer (a drill) and refilling with a resorbable and osteoinductive bone-graft substitute.

Simply, a better drill and filling the drill holes with bone grafts. The better idea did not work out. This examination appeared in the April 2017 issue of the  Journal of Tissue Engineering and Regenerative Medicine. (8)

Making core decompression work better – a better bone graft?

A later study from 2017 suggested that patients would have better success if their own bone graft, as opposed to donor bone, was used. As reported in the journal BioMed Central Musculoskeletal Disorders, in 75.9% the treatment was successful with no collapse of the femoral head or conversion to a total hip replacement. (9)

A May 2022 paper in the journal International orthopaedics (35) focused on the understanding of better bone graft outcomes. The researchers write: “Treatment of osteonecrosis of the femoral head at an early stage is a challenging issue. The modified minimally invasive core decompression combined with bone graft implantation remains controversial.” This study aimed to compare the early-middle outcomes of four groups with different bone grafts. The four bone grafts were: free fibular graft group, free vascularized fibular graft group, autologous iliac bone group, and β-tricalcium bioceramics phosphate graft group. Each group was treated with the modified minimally invasive core decompression and bone graft implantation.

All cases (192) were successful (10 hips would ultimately collapse) without any complications after the operation. The patients were followed up for 42 to 48 months. There were statistically significant differences among the four groups in operation time and blood loss. At the last follow-up, three hips collapsed on the femoral head in the free fibular graft group, two in the free vascularized fibular graft group, two in the autologous iliac bone group, and three in the β-tricalcium bioceramics phosphate graft group.

Making core decompression work better – the use of stem cells and blood platelets during surgery?

In this section, we will talk about treatments that we offer at our clinics, Platelet Rich Plasma therapy and stem cell therapy that is sometimes used by surgeons during decompression surgery to make the surgery work better. Let’s clarify and explain these treatment options.

We cannot help everyone with our treatments. Sometimes the hip is completely destroyed, such as in femoral head collapse, or large bone spurs have fused and locked the hip into a “rusted old joint,” that cannot be budged. Sometimes a hip replacement has to be recommended. We are hopeful that we see patients before they have reached this point of significant degeneration.

In 2012 doctors in Spain publishing in Knee Surgery, Sports Traumatology, Arthroscopy (10) wrote:

CONCLUSIONS: Arthroscopic management of avascular necrosis of the femoral head is viable and has significant advantages (especially when PRP is added).

“Therapies such as additive stem cells or platelet-rich plasma (PRP) combined with core decompression have yet to prove their efficacy.”

This is not a widespread adapted procedure. It is what is called in medicine a “novel approach,” meaning new, unusual, not regular procedure. This research was hardly followed up. In 2018, German doctors wrote in the journal Der Orthopäde (The Orthopedist) (11) “therapies such as additive stem cells or platelet-rich plasma (PRP) combined with core decompression have yet to prove their efficacy.”

Are Bone Marrow-Derived Stem Cells A Realistic Treatment?

Bone Marrow is the liquid spongy-type tissue found in the hallow (interior) of bones. It is primarily a fatty tissue that houses stem cells that are responsible for the formation of other cells. These mesenchymal stem cells (MSC), also called marrow stromal cells, can differentiate (change) into a variety of cell types including osteoblasts (bone cells) and chondrocytes (cartilage cells), fibroblasts (ligament and tendon), and others when reintroduced into the body by injection.

In treatment without surgery, the bone marrow is taken from the iliac crest of the pelvic bone in a simple drawing procedure. The bone marrow is either centrifuged to create a bone marrow aspirate concentration which is injected into the problem hip, or the bone marrow is injected directly into the problem hip without the concentration. We have published research on both these methods and this is discussed below.

Bone Marrow-Derived Stem Cells use during surgery, more research

In 2017 Doctors at the University of Milan also examined the role of bone marrow aspirate during core decompression surgery. In their study in the medical journal EFORT Open Reviews,(12) they cited the 2016 work of Greek and English researchers in the journal Acta Orthopaedica (13) showing that the application of autologous bone marrow concentrate in combination with core decompression is superior to core decompression treatment alone, as it was found to markedly decelerate the progression of the disease to the stage of femoral head collapse. This procedure also limited the need for total hip replacement, particularly when employed in the early (pre-collapse) stages of avascular necrosis of the femoral head.

In 2016 Dr. Ahmed M Samy of the Department of Orthopedics, Tanta University, Egypt wrote in the Indian Journal of Orthopaedics that mesenchymal stem cells and platelet-rich plasma (PRP) have been used as an adjunct to core decompression to improve clinical success in the treatment of pre-collapse hips. (14)

Mayo Clinic findings on using PRP and stem cells during the core decompression surgery – corticosteroid-induced osteonecrosis

In February 2018, doctors at the Mayo Clinic reported on their findings in patients who underwent core decompression for steroid-induced bone loss who had bone marrow aspirate stem cells and platelet-rich plasma introduced into the bone during the surgery. The research was published in the journal Clinical Orthopaedics and Related Research. (15)

Here are their learning points:

Study participants

Study observations

Conclusions:

Can you avoid the surgery?

Bone marrow stem cells and PRP may be beneficial during surgery. How about the treatments without surgery? Treating avascular necrosis without core decompression 

Using stem cells taken from a patient’s bone marrow is becoming a therapy of interest due to the potential of these mesenchymal stem cells to differentiate into other types of cells such as bone and cartilage. In the more than 26 years of experience, we have worked with patients in varying degrees of osteoarthritis, nothing sounds more terminal and ominous than the patient being told by another doctor that their bone is dying or they have necrosis, dead bone cells. Bone Marrow stem cell therapy may offer benefits to some of these patients. At this point, we would also like to point out that we do not offer stem cell therapy to every patient. Many times simple dextrose or PRP injections will offer the same outcome expectation.


Who would be a good candidate for Prolotherapy and stem cell injections as an alternative to core decompression surgery?

In this video Ross Hauser, MD presents guidelines for determining realistic expectations and when Prolotherapy and Bone Marrow stem cells may provide an option. The video bullet points are below.


Supportive research: PRP and stem cells

Clearly, we are not the only researchers showing success with bone marrow stem cell treatments or PRP treatments outside of surgery.

Avascular Necrosis AVN of the hip. In this mage AVN of the right hip is shown in a 44 year old patient who had been recommended to total hip replacement. This patient was treated six times with bone marrow aspirate and Prolotherapy over the course of 10 months with gradual resolution of symptoms and the ability to avoid surgery.

Avascular Necrosis AVN of the hip. In this mage AVN of the right hip is shown in a 44-year-old patient who had been recommended for total hip replacement. This patient was treated six times with bone marrow aspirate and Prolotherapy over the course of 10 months with gradual resolution of symptoms and the ability to avoid surgery.

In one case published in PM & R: The Journal of Injury, Function, and Rehabilitation, PRP was found very effective for advanced-stage degenerative AVN of the hip, with the patient demonstrating significant functional improvements and the ultimate outcome of being able to avoid surgery. (18.)

An April 2015 study in the Journal of Cellular Biochemistry reported exciting news about stem cell therapy as a new modality of treatment in bone lesions that could not be treated with autologous bone grafting. However, while successful results were reported from individual studies, the paper said more studies were needed to validate stem cell therapy injections, an established treatment for bone regeneration. (19)

The application of ‘regenerative medicine’ has given new hope to surgeons for the treatment of several chronic diseases and disorders including severe orthopedic conditions. There is a myriad of orthopedic conditions and injuries that presently have limited therapeutic treatments and could benefit from new developing therapies in regenerative medicine with the help of stem cell therapy. (20)

In other research, doctors confirmed that stem cell therapy for bone regeneration worked outside of surgery.

This was acknowledged in November 2015: Military university researchers in China reviewing the use of mesenchymal stem cells in the medical journal Biological Research say:

“Bone is a unique tissue that could regenerate completely after injury rather than heal itself with a scar. Compared with other tissues the difference is that, during bone repairing and regeneration, after the inflammatory phase the mesenchymal stem cells (MSCs) are recruited to the injury site and differentiate into either chondroblast (cartilage) or osteoblasts (bone) precursors, leading to bone repairing and regeneration. With this multilineage potentiality (the ability to change), the MSCs are probably used to cure bone injury and other woundings in the near future.”(21)

These findings are among the many research papers of the last two years that support the idea of bone regeneration in necrosis patients.

A study published in the Journal of Orthopaedic Surgery and Research found that Fat (adipose) based MSC and PRP stimulated the articular extracellular matrix and reduced damaging inflammation in dogs with osteoarthritis. (23)

Researchers publishing in the publication Cell Journal examined the use of Distraction osteogenesis – large volume expanded bone growth needed for limb lengthening. They tested bone growth using either a combination of stem cells and Platelet Rich Plasma Therapy or Platelet Rich Plasma Therapy alone. They found the combination of stem cell therapy and platelet-rich plasma therapy provided superior results for accelerated bone growth. (24)

In an animal study, doctors examined stem cells for bone regrowth in the jawbones of rats who had bisphosphonate-related osteonecrosis (Bisphosphonates, when administered intravenously for the treatment of cancer, have been associated with osteonecrosis of the jaw). Publishing in the Journal of Cranio-maxillofacial Surgery, they found adipose-derived mesenchymal stem cells provided significant bone regrowth. (25)

Stem cell augmentation may stop the progression of bone degeneration

In October 2020 a paper published in the journal Stem Cell Research & Therapy wrote: (26) “several studies have reported short-term efficacy of stem cells on early-stage osteonecrosis of the femoral head. However, its long-term effect was still unclear, especially on progression events. This study was performed to evaluate the long-term efficacy and safety of stem cells and analyze their optimal age group and cell number. Our findings build solid evidence that stem cell therapy could be expected to have a long-term effect on preventing early-stage osteonecrosis of femoral head patients from progression events, such as the collapse of the femoral head and total hip replacement. Furthermore, patients under 40 may be an ideal age group. . .”

Research supporting the use of dextrose Prolotherapy injections alone

In the June 2019 issue of the journal Alternative Therapies in Health and Medicine (27), doctors discussed a case history of a patient who had developed Avascular necrosis of the femoral head from long-time and uncontrolled glucocorticoid use. In the treatment of the case, the doctors used Prolotherapy injections. After the sixth session of Prolotherapy injections, the patient was able to do daily activities as the same as the previous physical and effort capacity. The doctors noted that: “We obtained successful outcomes in terms of patient satisfaction and clinical and radiological parameters with Prolotherapy injections. Prolotherapy may be useful as an easily applicable and satisfying auxiliary method for the treatment of Avascular necrosis of the femoral head.”

Summary

The standard treatments for AVN seemingly lead to a singular destiny – joint replacement. But are there realistic options? Case studies started to appear in the medical literature which explores Prolotherapy, Platelet Rich Plasma, and Stem Cell Therapy as possible solutions to bone death.

In our own clinical experience, we have seen similar results in patients who were given two options only – bilateral core decompression surgery or bilateral total hip replacement surgery. Patients should have been given the non-surgical option.

In summary: AVN cases are typically not treated any differently with Prolotherapy than any other case of hip pain. At our center we will evaluate the amount of instability, the bony contour, functional goals of the person, current physical examination and systemic health in order to develop the best treatment plan. The earlier the AVN is treated, the better the bony contour, the better the health of the person, then the better the prognosis of a good outcome with Prolotherapy. Because of the aggressive nature of AVN progression, typically PRP and/or stem cell Prolotherapy is recommended even on the first visit.  This approach may help stop the progression of the disease.

It seems it is time for a new etiology for AVN: hip joint instability. If the vascular system of AVN is intact, then it would make sense that growth factors through PRP and stem cell injections into the joint could make it inside the bone through the femoral head vascular system. Researchers have shown that in AVN, mesenchymal stem cells have a reduced ability to differentiate and thus build bone.(38)

Do you have a question about core decompression? Get help and information from our Caring Medical staff

References:

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This article was updated August 4, 2022

 

 

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