Cervical artificial disc replacement complications

Ross Hauser, MD. Caring Medical Florida

Cervical artificial disc replacement complications

In this article, we will discuss the challenges patients may face after cervical artificial disc replacement.

We generally see three types of patients when the subject is artificial disc replacement surgery.

  • We see the patients who underwent surgery with less than beneficial results, still have pain or adjacent segment problems and are looking to avoid another or revision surgery
  • We see the patients who underwent a successful surgery but still have some pain and limitations that continue to hinder them.
  • We see the patients who are trying to avoid the surgery altogether.

Many people have had successful cervical artificial disc replacement surgery and are happy people. These are typically not the patients that seek our help.

Before we begin this article and research findings, if you would like to contact our medical team, please use our contact form page. We can help assess your candidacy for our treatments and answer your questions.

“I had two consultations for surgery”

This is the type of story patients share with us. They tell us about cortisone injections in the neck as a last attempt to avoid surgery, the home remedies of stretching, yoga, and traction. They hope, at the least, these remedies and treatments will help them avoid surgery in the near future. They will also tell us multi-segment degenerative disc disease and cervical disc bulging, maybe from C3 – C7 or C2 – C5. They tell us about the surgeon who reviewed their MRI and that doctor’s suggestion to surgery because of developing bone spurs. Then they will tell us about a second opinion they got.

  • In one opinion, traditional cervical fusion with multi-level disc replacement would be suggested.
  • In another opinion, from a minimally invasive cervical spine specialist, the suggestion was laser surgery to burn away the bulging areas compressing the nerves. No fusion, no disc replacement but no guarantee that this surgery would prevent the need for cervical fusion later. This may often lead people to question the benefit of laser spine surgery and go ahead with the artificial disc/fusion surgery.

We will now focus on the artificial cervical disc replacement.

Cervical disc replacement may not recreate the normal range of cervical spine motion. This may cause problems down the road.

As we will see in the research below, one of the given benefits discussed with surgical candidates of cervical disc replacement is a better range of motion in the neck compared to the traditional fusion. We will explore just how much better it is or is not in the surgical studies we are presenting here.

One of the problems that patients seek to solve with a cervical disc replacement is that abnormal motion that they are already suffering from in their neck that is causing them many challenges. They have hope that surgery will remedy this problem. For some people, this may be a false hope.

A September 2019 study in the journal World Neurosurgery (1) suggests that “simply understanding ranges of motion (ROMs) does not capture the quality of normal cervical motion.”

In other words, cervical disc replacement may not recreate normal range of cervical spine motion. Remember, this comes from surgical research, it is the surgeons themselves expressing these concerns and represents the challenges some find with artificial cervical disc replacement. This research is discussed further below.

Before we go further, let’s understand again that there are many people who get a great benefit from a cervical artificial disc replacement surgery. There are a lot of people who do well with the “hybrid” surgery of anterior cervical discectomy with fusion plus cervical artificial disc replacement surgery when multiple areas of the cervical spine are causing them pain. The people who have successful surgery are, however, not typically the patients that we see in our office. But we do see a lot post-surgery:

  • We see that patient with new pain issues following the surgery that was suppose to resolve their old pain issues.
  • We see the patient who feels that their cervical spine could be stronger and more stable following the surgery.

Generally, people who have had a successful cervical artificial disc replacement surgery will report problem situations like this:

  • I feel great, the nerve pain is much less. I do have spasms in my neck and shoulders. I cannot resume my old activities yet and it is somewhat frustrating. I have been in Physical Therapy for 6 months. I may need more surgery because the other discs are now showing compression. I am looking for other options moving forward.

Or,

  • I decided on the hybrid surgery. I had C6/C7 fused with anterior cervical discectomy with fusion (ACDF). My surgeon recommended that to preserve range of motion I get the artificial discs at C4 and C5. The surgery went well, I take muscle relaxants mostly, painkillers sometimes. However, my neck does not feel strong and there is a concern that I may need more surgery.

A weakness in their ability to “hold their head up.”

The reason that these people come to our office is that they are exploring regenerative medicine treatments that may help them avoid further surgery by strengthening their cervical spine by way of addressing cervical ligament damage and weakness. We will discuss this below. They may also be in our office looking for ways to strengthen their cervical spine even after successful surgery but they feel something is not right. In some of these patients, they recognize a weakness in their ability to “hold their head up.”

In this video, Ross Hauser explains how even after disc replacement surgery, cervical spine instability is not only present, but has been made worse.

Again, let’s point out that many people get significant benefit from cervical disc replacement. These are the people we do not see in our office. We see the people who had disc replacement and continued or worsening problems.

A summary transcript and explanatory notes are below the video.

I’m seeing a lot more disc replacement patients with continued neck problems

  • We are seeing a lot more disc replacement patients because of the popularity of  the surgery. Surgeons are using disc replacement as an alternative to cervical fusion surgery.

The belief is that disc replacement can provide stability as well as a more natural motion. For some people this did not work out.

    • Some doctors believe that cervical disc replacement will be a better choice surgery because they believe that the problem is from severe disc degeneration and what we’re finding is that, unfortunately, after they put in the disc replacement some of the time that area of the disc replacement doesn’t stabilize. What does this mean?
      • When a disc replacement is performed, the surgeons have to move or stretch the cervical spine ligaments. Sometimes after the surgery those ligaments don’t tighten back up. This is why some people who had a disc replacement and come in and they feel just as bad or even worse after the surgery

At 1:10 of the video, Dr. Hauser shows on a Digital Motion X-Ray (DMX) how one patient continued to suffer from cervical spine instability 

What is Dr. Hauser demonstrating with the tongue depressor?

In the video, (1:40) the patient with the disc replacement is moving their head forward. The DMX image is stopped so the cervical spine instability can be demonstrated.

  • When a person moves their head forward, the cervical vertebrae should line up in an anatomically correct position. In this case, the patient’s vertebrae do not line up.
  • Dr. Hauser uses the tongue depressor to show that the vertebrae do not line up in a straight line, it is a crooked line with space gaps – unnatural distance or space between the vertebrae

DMX image of what Dr. Hauser is showing with the tongue depressor: (Note the bottom vertebrae, that is where the disc replacement is)

The person in this DMX image did not have the disc replacement that long ago. So the cervical spine instability see at C2 C3 C4 C5 C6 has probably been there for some time. This is why disc replacement at C6 did not help their neck problems at C2-C5

  • The person in this DMX image did not have the disc replacement that long ago. So the cervical spine instability see at C2 C3 C4 C5 C6 has probably been there for some time. This is why disc replacement at C6 did not help their neck problems at C2-C5

Neck pain after C5-C6 disc replacement surgery
An introductory video discussion with Ross Hauser, MD

In this video, Ross Hauser, MD, explains pain after disc replacement surgery. These are the learning points:

  • The patients we see come in with cervical spine instability after cervical neck disc replacement.
  • Demonstrating from a still image from a patient’s Digital Motion X-ray – a situation of offset cervical vertebrae is shown.
  • In a situation of offset vertebrae, the cervical ligaments that hold the vertebrae are so loose and weak that the vertebrae float away from each other. In this video the situation is demonstrated with problems at C5 – C6 following a disc replacement.
  • The patient suffered from symptoms of clicking, grinding, muscle tension. The muscle tension is created to help protect the spinal cord from the floating instability of C5-C6.
  • The case documented in this video is very severe instability. If the patient’s muscles did not “clamp down,” on the unstable area, each time the patient looked down, the vertebrae would be pressing into the spinal cord and the nerves that pass through C5-C6.
  • Prolotherapy injections which are explained below, help tighten and strengthen the spinal ligaments. In this patient’s case 6 – 8 treatments may be required.


Artificial Disc Replacement – Who is it best for? Who is not a candidate?

In a cervical artificial disc replacement surgery, the herniated or damaged disc between the vertebrae is removed. As opposed to a fusion surgery where bone and graft are inserted into the void created by the disc removal and then the vertebrae of the cervical spine are held together with rods and screws, the artificial disc replacement surgery inserts a ball and socket joint apparatus. The idea is that this ball and joint can do the job of a natural disc by maintaining disc height and preventing the vertebrae from rubbing against each other, reduce compression on the nerves, and maintain mobility in the cervical spine and a proper range of motion.

As a lesser procedure to bone graft, surgeons hope that they can complete the procedure within 2 hours, have the patient go home the next day, and have them return to a normal lifestyle within 2 months.

The benefits over spinal fusion in discussions between surgeons is

  • Patients can move right away and do not need to wear a neck brace
  • Faster recovery
  • Better long-term relief than cervical spinal fusion
  • Restored range-of-motion is very close to the range of motion of a healthy disc.

However,

  • Cervical disc replacement may not be the best option for people with significant spinal degeneration, multilevel herniation, loss of natural spinal curve, people with spinal cord compression. They, according to surgeon comparisons would benefit most from spinal fusion.

A comparison of surgical techniques – fusion vs. disc replacement – it is about motion

If you have been recommended to a disc replacement fusion surgery, one of the main aspects of this recommendation is your need to have some type of movement in your neck and that you are a candidate for this type of surgery.

We are going to explore a June 2020 study from the Department of Neurosurgery, Medical College of Wisconsin. It was published in the Journal of the Mechanical Behavior of Biomedical Materials.(2) Let’s let the surgeons explain the differences and comparisons between anterior cervical discectomy and fusion and cervical disc arthroplasty or replacement:

“Surgical treatment for spinal disorders, such as cervical disc herniation and spondylosis, includes the removal of the intervertebral disc and replacement of biological or artificial materials. In the former case, bone graft is used to fill the space, and this conventional procedure is termed anterior cervical discectomy and fusion. The latter surgery is termed as artificial disc replacement or cervical disc arthroplasty. Surgeries are most commonly performed at one or two levels.”

Range of motion and anterior and posterior load sharing

The question that these researchers were asking in this study was to determine the external (range of motion, ROM) and internal (anterior and posterior load sharing) responses of the spines with one-level and two-level surgeries in both models (anterior cervical discectomy and fusion and cervical disc arthroplasty / replacement).

“Results for both one-level and two-level surgeries showed that anterior cervical discectomy and fusion decreases range of motion at the index level (the surgery segments or levels), while cervical disc arthroplasty / replacement increase motions compared to the intact normal spine.

The ROM, anterior column load (pressure on the front-facing part of the cervical vertebrae), and  posterior column load (pressure on the rear part of the cervical vertebrae) increased at both adjacent levels for the anterior cervical discectomy and fusion while cervical disc arthroplasty / replacement showed a decrease.”

Suspected facet joint disease after surgery

“Although two-level surgeries resulted in increased these biomechanical variables, greater changes to adjacent segment biomechanics in anterior cervical discectomy and fusion may accelerate adjacent segment disease. Decreased ROM and lower load sharing in cervical disc arthroplasty / replacement may limit adjacent segment effects such as accelerated degeneration. Their increased posterior load sharing, however, may need additional attention for patients with suspected facet joint disease.”

So to recap. The benefit of cervical disc arthroplasty / replacement surgery is better range of motion and less risk of Cervical adjacent segment disease, as compared to traditional cervical spine fusion. However, the cervical disc arthroplasty / replacement surgery may accelerate facet joint disease. Let’s again refer to the research above. “Cervical disc replacement may not recreate normal range of cervical spine motion.” Just having more range of motion is not beneficial if it is creating a hypermobile situation that is causing the development of osteoarthritis and bone spurs.

How cervical surgery positively or perhaps negatively affects a patient is done via comparison of surgical techniques

We are going to return now to the 2019  research we cited above and the discussion of how cervical surgery positively or perhaps negatively affects a patient is via comparison of surgical techniques. This is demonstrated with a September 2019 study in the journal World Neurosurgery (1).  Here the researchers “evaluated clinical and radiologic results as well as biomechanical changes after anterior cervical discectomy and fusion, cervical disc replacement, and posterior cervical foraminotomy. (a minimally invasive surgical procedure performed from the back) and/or discectomy in individuals with unilateral single-level cervical radiculopathy.

  • A total of 97 patients received surgical treatment for unilateral intolerable radiculopathy.
  • Clinical outcomes included pain scores for neck and arm pain, neck disability scores, and modified Odom’s criteria (A scoring system to assess the outcome of the cervical surgery.)
  • Also measured was the cervical spine range of motion for the whole cervical (C-ROM), operated segment (S-ROM), and upper and lower adjacent segment.

RESULTS:

  • A total of:
    • 55 anterior cervical discectomy and fusion,
    • 21 cervical disc replacements, and
    • 21 posterior cervical foraminotomies were performed.
  • Clinical improvement in neck disability and pain were significant after surgery; however, there was no statistical significance among groups.
  • Satisfaction rate
    • posterior cervical foraminotomy (76.2%)
    • anterior cervical discectomy and fusion (90.9%) and
    • cervical disc replacement (90.5%) without statistical difference.
  • Range of motion was reported as only slightly better in the cervical disc replacements and posterior cervical foraminotomy groups, without statistical significance. Complete range of motion significantly increased in cervical disc replacement, slightly increased in the posterior cervical foraminotomy group as compared to the results of the anterior cervical discectomy and fusion group, where the cervical range of motion decreased.

Comparatively:

  • Anterior cervical discectomy and fusion provide the lowest reoperation rate.
  • Cervical disc replacement is effective in ameliorating cervical range of motions.
  • Posterior cervical foraminotomy has a greater probability of reoperation; however, range of motion after surgery is better than with anterior cervical discectomy.

Yet within the medical community is a debate between what is considered successful cervical artificial disc replacement, when cervical artificial disc replacement should be chosen over anterior cervical discectomy with fusion, and when patients should reconsider the surgical recommendation.

If you can make the neck move more naturally, the better the chance treatment will have in achieving success.

Some of the controversial issues surrounding cervical neck surgery is the movement and range of motion, or lack thereof, of the cervical spine following neck surgery. Even in artificial disc surgery, there is a question as to how much, natural movement can be restored. In the above research and research below, a key benefit is the improved range of motion with the disc replacement.

“The complications after total disc replacement surgery are thought to be caused by inadequate natural movement restoration.”

In research from the Department of Orthopedic Surgery, Newton-Wellesley Hospital/Harvard Medical School, published in the Journal of Orthopaedic Translation, July 2019, (3) doctors wrote: “The subaxial cervical spine (C3, C4, C5, C6, C7) is the most mobile region of the cervical spine, allowing positioning of the head in a multitude of positions for various activities of daily living. As the discs degenerate, the relationship between alteration in kinematics (natural motion), resting alignment and symptom development is not clear.”

(Explanatory note: As cervical degenerative disease occurs, it is not clear what causes the development of the person’s pain challenges or what causes one person to have symptoms of cervical spine degenerative disease and why another person with similar degenerative disease will have no symptoms.)

  • The research continues: “Surgical treatment of disc degeneration not responding to conservative measures with anterior cervical discectomy with fusion has been the gold standard although concern remains regarding the development of adjacent segment disease. Although total disc replacement (TDR) and other motion-preserving technologies are becoming popular alternatives that are capable of restoring the cervical spine motion, recent follow-up studies indicated that symptomatic adjacent segment degeneration is not eliminated and reoperation rates of approximately 9% were reported at 24 months after surgery. The complications after total disc replacement surgery are thought to be caused by the inadequate restoration of the in vivo (within) intervertebral kinematics of the affected segments.” (Note: How the c3-c7 segment moves after surgery).

Again, what the research suggests is that:

  • For some patients, symptomatic adjacent segment degeneration is not eliminated and reoperation rates of approximately 9% were reported at 24 months after surgery.
  • The complications after total disc replacement surgery are thought to be caused by inadequate natural movement restoration

Returning to the research:

  • “Simply understanding ranges of motion (ROMs) does not capture the quality of normal cervical motion, nor does it allow appreciation for the change in the quality of motion associated with disease development and restoration of quality motion through surgical treatment.”

The researchers of this study concluded that: “the subaxial cervical intervertebral center of rotation (the place where the vertebra anchors itself to support rotation) and range of motions were segment level- and neck motion-dependent. (Each vertebra had its own unique rotation and motions and fusing or replacing one or multiple segments will impact other non-surgical treated segments). This may help to improve the artificial disc design as well as a surgical technique by which the neck functional motion is restored following the cervical arthroplasty.”

In other words, there is a concern that cervical spine disc replacement surgery does not restore the normal motion of the cervical spine in some patients and that this lack of normal motion can cause post-surgical complications and complaints. Doctors should look for ways to make the neck move more naturally. If they can, the better the chance the surgery, or any treatment will have in achieving better success.

Surgeons ask: “Are Controversial Issues in Cervical Total Disc Replacement Resolved or Unresolved?”

In the February 2018 issue of the Asian Spine Journal, (4) Neurologists in Korea published these findings in their paper: Are Controversial Issues in Cervical Total Disc Replacement Resolved or Unresolved?: A Review of Literature and Recent Updates.

Here are the summary findings and learning points:

  • Since the launch of cervical total disc replacement in the early 2000s, many clinical studies have reported better outcomes of cervical total disc replacement compared to those of anterior cervical discectomy and fusion.
  • However, cervical total disc replacement is still a new and innovative procedure with limited indications for clinical application in spinal surgery, particularly, for young patients presenting with soft disc herniation with radiculopathy and/or myelopathy.
  • In addition, some controversial issues related to the assessment of clinical outcomes of cervical total disc replacement remain unresolved.
  • These issues, including surgical outcomes, adjacent segment degeneration, heterotopic ossification, wear debris and tissue reaction, and multilevel total disc replacement and hybrid surgeries are a common concern of spine surgeons and need to be resolved. Among them, the effect of cervical total disc replacement on patient outcomes and adjacent segment disease is theoretically and clinically important; however, this issue remains disputable.

Heterotopic ossification- the growth of bone in the tendons, muscles and soft tissue after cervical disc replacement

Heterotopic ossification is the unnatural formation of bone in the tendons, muscles, and other soft tissue. Speculation in the medical community that the acquired form of heterotopic ossification can occur when a muscle is injured. Muscle is injured during surgery. Let’s look at the research:

Doctors wrote in the journal Medicine – (5)

  • Occurrence of Heterotopic ossification is an inevitable postoperative complication after cervical artificial disc replacement and can decrease the range of motion at the segment where the disc was replaced. This they note is “contrary to the fundamental goal of an artificial disc.”
  • Previous studies reported various results on the occurrence of Heterotopic ossification.
    • One study they cite reports 17.8% of Heterotopic ossification occurrence in studied patients at 12 months of follow-up
    • Another cited study reported 78.6% patients exhibited Heterotopic ossification at an average follow-up period of 43.4 months.
  • In this study, the results of Heterotopic ossification and severe Heterotopic ossification were grouped into different subgroups, and the pooled data showed that the prevalence of Heterotopic ossification after cervical artificial disc replacement was:
    • within 1 to 2 years after surgery = 38% with a condition of severe Heterotopic ossification reported in 10.9%
    • within 2 to 5 years after surgery, and = 52.6 with a condition of severe Heterotopic ossification reported in 22.2%
    • within 5 to 10 years after surgery = 53.6% with a condition of severe Heterotopic ossification reported in 47.5%

What causes this?

Doctors at the Spine Institute of Louisiana wrote in a June 2018 study in the International Journal of Spine Surgery (6) that it is difficult to understand why Heterotopic ossification happens.

  • Heterotopic ossification is a known risk following cervical total disc replacement surgery, but the cause and effect of Heterotopic ossification are not well understood. Reported Heterotopic ossification rates vary, (as in the research documented above)  and few studies are specifically designed to report Heterotopic ossification.
  • The findings (of this study) are limited for clinical decision-making, because we cannot yet make causal inferences (a conclusion as to cause. The researchers concluded it happens, they are not sure why it happens. Other researchers have pointed out even if Heterotopic ossification occurs, many times it is asymptomatic and does not bother that patient at all.)
  • The rates of Heterotopic ossification were shown to progress over time, warranting further research into the relationship of Heterotopic ossification and inflammatory response.
  • There remains a paucity of literature analyzing potential surgical technique and implant-specific causes of Heterotopic ossification following cervical total disc replacement surgery. Further analysis needs to be conducted to understand the significance and relationship between each of these possible predictors, and other potential predictors, such as adjacent-level degeneration, sagittal alignment, and operative levels.
  • Although spine surgeons have traditionally referred to Heterotopic ossification as clinically relevant (symptomatic) and nonrelevant (asymptomatic), this nomenclature (classification) appears to be founded on Range of Motion and not impact on clinical outcomes. Based on this analysis, the largest to date, it seems clear that Heterotopic ossification terminology should be more accurately defined as motion-restricting and non–motion-restricting.

We would like to point out that a possible causation is adjacent-level degeneration and possible problems with the cervical neck sagittal alignment. The cervical spine’s natural alignment or curve.

In this video, Danielle R. Steilen-Matias, MMS, PA-C explains the challenges of adjacent segment disease

Summary transcript

  • We often get calls from patients who already had a cervical spine fusion or neck fusion surgery and are still suffering from the symptoms that sent them to the surgery in the first place, or, from patients for whom the cervical fusion helped initially, but the pain relief did not last and any relief was temporary.
  • Some patients did not have a full understanding of what the fusion outcome will be. The segment that is fused does not move. Yet the patient still has to do their best to have normal neck movement. They have to move their head. They want to look down and look up and move their heads in a normal way.
  • When you have have a neck segment fused, the segments above and below the fusion have to take on the extra stress of providing as normal neck movement as possible and they are overworked and develop adjacent segment disease, a rapid deterioration of the cervical spine.

A case presented

  • A female patient came in whom I treated. She had undergone two cervical fusions into the lower cervical spine.  We did a DMX or digital motion x-ray which is explained and illustrated below to look at how unstable her neck was and we could see that the segment above her fusion was unnaturally moving all over the place. She had the fusion surgery 8 years ago, so this constant strain and degenerative wear and tear condition have been going on for some time. When she came in for her treatments, the symptoms she described were similar to the symptoms she had experienced 8 years prior that lead to her initial fusion surgery. A lot of neck pain, muscle tightness from muscle spasms, pain running down her arm from the vertebrae pinching on the cervical nerves.
  • In her case, we determined that she would likely respond very favorably to Prolotherapy injections to stabilize the segment of her cervical spine instability.

Cervical spinal alignment and curvature after disc replacement surgery

Let’s point out again that people have good success with cervical disc replacement. In some instances, documented in the studies we will cite below, the disc replacement helped restore, in part, the natural alignment of the neck. In others, the artificial disc caused an unnatural curve and alignment in the neck that caused complications.

This is the progression of cervical neck instability. The neck has a natural “backward C” shape. Cervical instability causes a normal lordotic curve to end up as an “S” or “Snake” curve, or cervical dysstructure.

The Horrific Progression of Neck Degeneration with Unresolved Cervical Instability

While people have good success with cervical disc replacement, in some instances, documented in the studies we will cite in this article, the disc replacement helped restore, in part, the natural alignment of the neck. In others, the artificial disc caused an unnatural curve and alignment in the neck that caused complications. This image help-s documented the type of changes that can occur in the cervical spine.

In the European Spine Journal (7), medical university researchers in Italy researchers examined alignment at the cervical spine in patients following cervical disc replacement surgery.

Here is what they wrote:

“The alignment at the cervical spine has been considered a determinant of degeneration at the adjacent disc, but this issue in cervical disc replacement surgery is poorly explored and discussed in this patient population. The aim of this systematic review is to compare anterior cervical fusion and total disc replacement in terms of preservation of the overall cervical alignment and complications.”

“In most of the retrieved studies, a tendency towards a more postoperative kyphotic alignment in total disc replacement was reported. The reported mean (average) complication rate was of 12.5 % (0% in some research up to 66.2 % in other research). Complications associated with cervical prosthesis included heterotopic ossification, device migration, mechanical instability, failure, implant removal, operations, and revision.

“Even though cervical disc arthroplasty (replacement) leads to similar outcomes compared to arthrodesis (fusion) in the middle term follow-up, no evidence of the superiority of cervical total disc replacement is available up to date. We understand that the overall cervical alignment after total disc replacement tends towards the loss of lordosis, but only longer follow-up can determine its influence on the clinical results.”


The importance of the cervical spine curve in alleviating pain

  • In this video, Dr. Hauser presents a case of one of our patients that came over from Europe. This case will illustrate how important the cervical curve is.
  • In many patients we see the destruction of the cervical curve is just as challenging a problem as severe cervical spine instability.
  • This particular patient demonstrated symptoms following an airline flight 2 years ago.
    • Symptoms included Tinnitus, feeling that her head was in a vice, nasal stuffiness, and extreme sensitivity to light.
  • At 1:12 Dr. Hauser demonstrates a still image from the patient’s Digital Motion X-Ray. We see the loss of the cervical curve. This causes pressure and stretching of her spinal cord. This also alters the balance of her head on her neck and distributes the weight of the head in an unnatural manner. Further worsening symptoms. Dr. Hauser points out that the weight of the head will now stretch the cervical spine ligaments causing further cervical spine instability. The patient is in a significant degenerative condition.
  • At 3:07 of the video, you can see the patient’s neck motion under DMX x-ray.
  • The patient has severe cervical instability. The patients will require many Prolotherapy injections and help correcting the loss of her cervical curve.
  • Prolotherapy is an injection therapy given over many sessions. Normally we see patients every 4 to 6 weeks.

Surgical treatments for Cervical Instability – the disc may not be the problem causing pain, loss of cervical curvature, and loss or range of motion

In our practice, we see many patients, not only with neck pain and radiating pain into the back, shoulders, arms and hands, but also with a myriad of symptoms related to cervical neck problems that doctors feel an artificial disc may help remedy, those related to degenerative cervical disc disease including problems of pinched nerves.

cervical degenerative ligament disease

When spinal ligaments are exposed to continued compression or stress, they “Creep.” Creep is a medical condition that results from the deformity or elongation of the ligaments that hold the cervical spinal vertebrae in place. This is cervical neck instability.

CREEP – cervical degenerative ligament disease – why neck surgery fails

Some of the most debilitating conditions attributed to problems in the neck are those due to cervical instability caused ligament laxity. What does this mean? It means that surgery may not address the problems you are experiencing in your neck.

When spinal ligaments are exposed to continued compression or stress, they “Creep.” Creep is a medical condition that results from the deformity or elongation of the ligaments that hold the cervical spinal vertebrae in place. This is cervical spine instability.

  • The surgery that cuts away the cervical vertebrae bone that is pressing on the nerves – does not correct or prevent CREEP recurrence
  • The surgery that will fuse the cervical vertebrae in place so the vertebrae do not shift out of place and press on the nerves again, MAY NOT be needed at all if CREEP can be repaired and prevented by the use of non-surgical regenerative medicine techniques.
    • Regenerative medicine injection techniques such as Prolotherapy explained below, work on the same understanding as fusion surgery, but with big differences.
    • The regenerative injections repair the ligaments.
    • The injections strengthen the ligaments’ ability to hold the vertebrae in its natural position. Which is what the fusion seeks to do.
    • The big difference is that with fusion surgery you will lose a great amount of ability to turn your head from side to side and up and down. In Regenerative medicine injections the treatment repairs and allows for this natural movement of your head.

Range of motion issues are in the ligaments

A study came out of the University of Waterloo in Canada and was published in the November 2017 edition of the Spine Journal.(7) Briefly here was the problem and the goal of the study:

Loose ligaments are not normal

  • Predicting physiological (normal) range of motion (ROM) using a finite element (FE) model (a numeric scoring system) of the upper cervical spine requires the incorporation of ligament laxity.
    • COMMENT: The doctors understand that ligament laxity (CREEP) is a problem of stability and instability To come up with a scoring system to define the normal range of neck motion, you need to understand how loose ligaments are not normal.

Patients suffer from big problems caused by little damage to the ligaments

  • The effect of ligament laxity can be observed only on a macro level of joint motion and is lost once ligaments have been dissected and preconditioned for experimental testing.
    • COMMENT: It is hard on any level to accurately determine the amount of ligament damage to the amount of instability because even small injuries or damage, sometimes undetectable, cause big problems. This is what we call cervical ligament microinstability.

Patients suffer because Ligament laxity is a mystery

  • As a result, although ligament laxity values are recognized to exist, specific values are not directly available in the literature for use in finite element models.
    • COMMENT:  Ligament laxity is a mystery, defining it within mathematical equations for the scoring system is difficult. This is why cervical neck pain patients have a difficult time finding the right medical care. Their conditions if based on degenerative ligament disease is a mystery.

Patients suffer because cervical ligament laxity is a mystery


In this video, a demonstration of treatment is given

Prolotherapy is referred to as a regenerative injection technique (RIT) because it is based on the premise that the regenerative healing process can rebuild and repair damaged soft tissue structures. It is a simple injection treatment that addresses very complex issues.

This video jumps to 1:05 where the actual treatment begins.

This patient is having C1-C2 areas treated. Ross Hauser, MD, is giving the injections.

Treating cervical ligaments – published research from Caring Medical

In 2014 headed by Danielle R. Steilen-Matias, PA-C, our Caring Medical team published these findings in The Open Orthopaedics Journal.(8)

The capsular ligaments (the ligaments of the joint capsule) are the main stabilizing structures of the facet joints in the cervical spine and have been implicated as a major source of chronic neck pain. Such pain often reflects a state of instability in the cervical spine and is a symptom common to a number of conditions such as disc herniation, cervical spondylosis, whiplash injury, and whiplash-associated disorder, post-concussion syndrome, vertebrobasilar insufficiency, and Barré-Liéou syndrome.

When the capsular ligaments are injured, they become elongated and exhibit laxity, which causes excessive movement of the cervical vertebrae.

  • In the upper cervical spine (C0-C2), this can cause symptoms such as nerve irritation and vertebrobasilar insufficiency with associated vertigo, tinnitus, dizziness, facial pain, arm pain, and migraine headaches.
  • In the lower cervical spine (C3-C7), this can cause muscle spasms, crepitation, and/or paresthesia in addition to chronic neck pain.
  • In either case, the presence of excessive motion between two adjacent cervical vertebrae and these associated symptoms is described as cervical instability.

Therefore, we propose that in many cases of chronic neck pain, the cause may be underlying joint instability due to capsular ligament laxity. Furthermore, we contend that the use of comprehensive Prolotherapy appears to be an effective treatment for chronic neck pain and cervical instability, especially when due to ligament laxity. The technique is safe and relatively non-invasive as well as efficacious in relieving chronic neck pain and its associated symptoms.

Stabilizing the unstable neck – the case for treating ligaments with Prolotherapy

Back to our 2014 research headed by Danielle R. Steilen-Matias, PA-C, published in The Open Orthopaedics Journal. Here we outline that the problems of the cervical neck are not always problems of degenerative disc disease but problems of degenerative ligament disease. This explains why traditional treatments focused on the discs will not be successful in the long-term.

The use of conventional modalities for chronic neck pain remains debatable, primarily because most treatments have had limited success. We conducted a review of the literature published up to December 2013 on the diagnostic and treatment modalities of disorders related to chronic neck pain and concluded that, despite providing temporary relief of symptoms, these treatments do not address the specific problems of healing and are not likely to offer long-term cures.

The objectives of this study are to provide an overview of chronic neck pain as it relates to cervical instability, to describe the anatomical features of the cervical spine and the impact of capsular ligament laxity, to discuss the disorders causing chronic neck pain and their current treatments, and lastly, to present Prolotherapy as a viable treatment option that heals injured ligaments, restores stability to the spine, and resolves chronic neck pain.

There are a number of treatment modalities for the management of chronic neck pain and cervical instability, including injection therapy, nerve blocks, mobilization, manipulation, alternative medicine, behavioral therapy, fusion, and pharmacologic agents such as NSAIDs and opiates. However, these treatments do not address stabilizing the cervical spine or healing ligament injuries, and thus, do not offer long-term curative options. In fact, cortisone injections are known to inhibit, rather than promote, healing.

Research on 21 patients with cervical instability and chronic neck pain

In our research published in the European Journal of Preventive Medicine we presented the following findings:

  • Ninety-five percent of patients reported that Prolotherapy met their expectations in regard to pain relief and functionality. Significant reductions in pain at rest, during normal activity, and during exercise were reported.
  • Eighty-six percent of patients reported overall sustained improvement, while 33 percent reported complete functional recovery.
  • Thirty-one percent of patients reported complete relief of all recorded symptoms. No adverse events were reported.

We concluded that statistically significant reductions in pain and functionality, indicating the safety and viability of Prolotherapy for cervical spine instability.(9)

In summary, disc replacement surgery can help a lot of people, however, cervical degenerative disease may also be a problem of the cervical ligaments. Addressing the problems of weakened and damaged ligaments may help in alleviating your problems of cervical degenerative disease.

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References

1 Lin GX, Rui G, Sharma S, Kotheeranurak V, Suen TK, Kim JS. Does the Neck Pain, Function, or Range of Motion Differ After Anterior Cervical Fusion, Cervical Disc Replacement, and Posterior Cervical Foraminotomy?. World neurosurgery. 2019 Sep 1;129:e485-93. [Google Scholar]
2 Purushothaman Y, Yoganandan N, Jebasselan D, Choi H, Baisden J. External and internal responses of cervical artificial disc replacement, and anterior cervical discectomy and fusion: A finite element modeling study. Journal of the Mechanical Behavior of Biomedical Materials. 2020 Mar 22:103735. [Google Scholar]
3 Yu Y, Li JS, Guo T, Lang Z, Kang JD, Cheng L, Li G, Cha TD. Normal intervertebral segment rotation of the subaxial cervical spine: An in vivo study of dynamic neck motions. Journal of Orthopaedic Translation. 2019 Jan 21. [Google Scholar]
4 Park CK, Ryu KS. Are Controversial Issues in Cervical Total Disc Replacement Resolved or Unresolved?: A Review of Literature and Recent Updates. Asian spine journal. 2018 Feb;12(1):178. [Google Scholar]
5 Kong L, Ma Q, Meng F, Cao J, Yu K, Shen Y. The prevalence of heterotopic ossification among patients after cervical artificial disc replacement: a systematic review and meta-analysis. Medicine. 2017 Jun;96(24). [Google Scholar]
6 Nunley PD, Cavanaugh DA, Kerr EJ, Utter PA, Campbell PG, Frank KA, Marshall KE, Stone MB. Heterotopic ossification after cervical total disc replacement at 7 years—prevalence, progression, clinical implications, and risk factors. International journal of spine surgery. 2018 Jun 1;12(3):352-61. [Google Scholar]
7 Di Martino A, Papalia R, Albo E, Cortesi L, Denaro L, Denaro V. Cervical spine alignment in disc arthroplasty: should we change our perspective?. European Spine Journal. 2015 Nov 1;24(7):810-25.
8 Engquist M, Löfgren H, Oberg B. Surgery Versus Non-Surgical Treatment for Cervical Radiculopathy: A prospective, randomized study comparing surgery plus physiotherapy with physiotherapy alone with a two year follow-up. Spine (Phila Pa 1976). 2013 Jun 17.  [Google Scholar]
9 Steilen D, Hauser R, Woldin B, Sawyer S. Chronic neck pain: making the connection between capsular ligament laxity and cervical instability. The open orthopaedics journal. 2014;8:326.  [Google Scholar]
10 Hauser R, Steilen D, Gordin K The Biology of Prolotherapy and Its Application in Clinical Cervical Spine Instability and Chronic Neck Pain: A Retrospective Study. European Journal of Preventive Medicine. Vol. 3, No. 4, 2015, pp. 85-102. doi: 10.11648/j.ejpm.20150304.112396 [Google Scholar]

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