Why you should get Prolotherapy when you get stem cell treatments

Prolotherapy Knee articular cartilage repair without surgery

Ross Hauser, MD

In the simplest terms, Prolotherapy is the injection of sugar water into a damaged joint. Prolotherapy injections work to heal damaged joints by stimulating nature’s healing and regenerative processes through inflammation. Prolotherapy does so by causing a controlled, specifically targeted inflammation that helps grow new ligament and tendon tissue.

Stem cell therapy in an injection of your own harvested stem cells. Stem cell therapy is typically utilized when we need to “patch” holes in cartilage and stimulate bone. We explore this option in patients when there is a more advanced osteoarthritis and a recommendation to a joint replacement has been made or suggested.

Why you should get Prolotherapy when you get stem cell treatments

In the introduction to this article, you see that Prolotherapy works on ligaments and tendons, the stabilizing structures of the joint. You also see that stem cell therapy works on addressing the problems of bone on bone and advanced joint degeneration. Utilizing the two treatments together seems to make perfect sense in that you are providing a multi-injection comprehensive approach to joint healing. Watch the video, it is the treatment on my own knee.

Another reason why you should get Prolotherapy when you get stem cell treatments. Dextrose Prolotherapy provides stem cells with their favorite food.

In my published research in the journal Clinical medicine insights. Arthritis and musculoskeletal disorders. I along with my co-author Amos Orlofsky, Ph.D. of Albert Einstein College of Medicine were able to demonstrate and document these clinical results in patients receiving bone marrow-derived stem cells and dextrose Prolotherapy.(1)

  • Seven patients with hip, knee or ankle osteoarthritis received two to seven treatments over a period of two to twelve months of bone marrow-derived stem cells and dextrose Prolotherapy.
  • All seven patients reported improvements with respect to pain, as well as gains in functionality and quality of life.
  • Three patients, including two whose progress under other therapy, had plateaued or reversed, achieved complete or near-complete symptomatic relief, and two additional patients achieved resumption of vigorous exercise.

You can read about these people here Bone marrow aspirate concentrate | Published review 7 case histories

What you will read about these people is that they had the comprehensive treatment we discussed above. Dextrose Prolotherapy to the ligaments and tendons and stem cells to fix the holes. What they also had was well satiated and fed stem cells.

A little extra sugar stimulates bone marrow-derived mesenchymal stem cells to multiply in numbers.

We are going to bring in research and an important published paper from Purdue University to help understand and confirm the notion that dextrose, especially hypertonic (extra) dextrose is a significant factor in the ability of mesenchymal stem cells from bone marrow to proliferate.(2)

Simply, the researchers took stem cells and glucose and put them in an experimental situation. The experiment was to see how varying levels of glucose affected stem cell numbers (proliferation).  What the experiment found was that mesenchymal stem cell consumption of glucose increased proportionally with the glucose concentration in the medium. The more glucose, the more the stem cells ate, the more the stem cells multiplied.

In summary, hypertonic dextrose in published studies helps stem cell proliferation in vitro (in cultures.)  While this is important, more important is what it does in the human body.  We have written numerous studies on hypertonic dextrose Prolotherapy and stem cells and feel the results speak for themselves.

If you have questions and would like to discuss your pain issues with our staff you can get help and information from us.

Prolotherapy Specialists

1 Hauser RA, Orlofsky A. Regenerative injection therapy with whole bone marrow aspirate for degenerative joint disease: a case series. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders. 2013 Jan;6:CMAMD-S10951. [Google Scholar]

2 Deorosan B, Nauman EA. The Role of Glucose, Serum, and Three-Dimensional Cell Culture on the Metabolism of Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cell International. 2011;  Article ID 429187, 12 pages. Doi:10.4061/2011/429187 [Google Scholar]

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