Caring Medical - Where the world comes for ProlotherapyBaker’s cyst treatment – Prolotherapy Injections

Ross Hauser, MD., Caring Medical Regenerative Medicine Clinics, Fort Myers, Florida
Danielle R. Steilen-Matias, MMS, PA-C., Caring Medical Regenerative Medicine Clinics, Oak Park, Illinois
David N. Woznica, MD., Caring Medical Regenerative Medicine Clinics, Oak Park, Illinois

Baker’s cyst treatment – Prolotherapy Injections

When you have knee instability, your knee is loose, your knee is painful, and, your knee may give way or buckle or catch at any step of the way. This is obviously not a normal condition and one your body tries to react to and correct. How does your body react? Swelling, lots of swelling. Your body’s natural response to knee looseness and instability is to swell up the knee with fluid. However, chronic knee swelling and synovial inflammation is not a normal situation either. Your knee cannot be in a constant state of inflammation.

The swelling or accumulation of fluid in the knee occurs, and is there, to act as a temporary brace, a sort of “water cast.” The “fluid brace,” is trying to keep everything in place as best it can. In the case of a Baker’s cyst, there is too much accumulation of fluid and a bulge, sac, or cyst forms behind the knee, causing discomfort, difficulty bending the knee, stiffness and pain.

For many people, a visit to the orthopedist will result in an aspiration or draining of the cyst. This will usually provide immediate relief as the pressure of the swelling on the knee and calf is removed. For many people, a cortisone injection will be given immediately following the aspiration to shut down any inflammation that may cause the cyst to reappear. After the aspiration and possible cortisone shot, the patient will be told, “there is a great chance this will come back. If you start having knee pain, come back and we will do an MRI to see what is happening in your knee.

In this brief video a demonstration of aspiration of the Baker’s Cyst and knee instability treatment

  • At 0:50 seconds, demonstration of draining the Baker’s cyst under ultrasound guidance prior to Prolotherapy treatment. Prolotherapy is a simple series of dextrose injections that are explained below.
  • At 1:05 Treating the knee instability with Prolotherapy and combining Platelet Rich Plasma injections. Platelet Rich Plasma is using your own blood platelets to accelerate healing. The treatment is explained in fuller detail below.
  • At 1:13 demonstration of the treatments on a patient’s knee

The problem is not the Baker’s Cyst. The problem is what is causing the Baker’s Cyst

If you have a Baker’s Cyst or worse, recurring Baker’s Cyst, you probably have an MRI that shows “degenerative changes in the knee”, “meniscus tears“, and “articular cartilage damage.” Your knee pain specialist has likely discussed with you that your Baker’s Cyst is a symptom of this degenerative damage, not the cause of it. Your doctor may tell you, “I can keep draining the cysts as it becomes a problem for you, but we should look to address the problem of what is causing it so we can see if we can provide a long-term cure.”

Let’s point out again, a lot of people have a Baker’s Cyst drained, they get or do not get a cortisone injection, and that is the only time that the Baker’s Cyst will be a problem for them. These people may have had an isolated knee injury that promoted the formation of the Baker’s Cyst. When that knee injury healed, the Baker’s Cyst could be drained and this would be the end of it. These are not the people we see in our examination rooms.  The people we see have had multiple cysts, multiple aspirations to the point where aspiration is no longer possible, and a recommendation to arthroscopic knee surgery or already had an arthroscopic knee surgery. The people we see did not get the long-term or curative relief from these recommended treatments and their knee is much worse.

Simple Baker’s Cyst becomes complicated Baker’s Cyst

One morning you may have arisen and your calf and ankles were filled with fluid. This caused you a great concern as you may not be aware that your Baker’s Cyst could rupture and you are thinking the worst. You were probably relieved when you went to your doctor and you were told “your Baker’s Cyst ruptured, all this fluid will eventually be reabsorbed into the body, keep your leg elevated, take anti-inflammatories, and if need be, pain-killers until this goes away.”

Of course, this doesn’t just happen when you go to sleep, people report that they “popped,” their cyst walking upstairs or simply walking at a brisk pace. Some reported that they had so much fluid behind their knee that when it popped their calf and shin “weeped,” water for days. For some people, even this may simply go away. For many others, the simple Baker’s Cyst (the one and done type)  has turned into the complicated Baker’s Cyst, (I am here to stay type) and I can rupture frequently.

In a July 2019 study, published in the American Journal of Physical Medicine & Rehabilitation (1),  specialists examined 47 knees with Baker’s Cyst in 45 patients (2 patients had the Baker’s Cyst in both knees.)

What makes for a Complicated Baker’s Cyst?

  • Ultrasound findings which show the spread of a more thicker (gel-like) fluid into the front of the knee (the suprapatellar recess or bursa area).
    • Note: As Baker’s Cysts continue to form, the fluid within them become thicker and thicker. The body is producing a “heavier grade oil.” This heavier grade makes future aspirations difficult and at some point impossible.
  • Synovial inflammation and chronic swelling
  • Greater knee pain
  • Clear indication of advanced osteoarthritis including greater prevalence of bone spurs
  • Evidence of Meniscus tears

Of the 47 knees:

  • There were 22 knees with a simple cyst and
  • 25 knees with a complicated cyst.

As we mentioned above, in our clinics it is usually the complicated cyst people we see.

The surgical treatment of Complicated Baker’s or Popliteal synovial cysts remains controversial

There are not many treatment options for a complicated Baker’s Cyst because the complicated Baker’s Cyst is secondary to other knee problems. So we have people who come into our clinics, we ask them what type of treatments have you received? They tell us non-steroidal anti-inflammatory drugs and when the initial doses did not provide relief they got larger doses at a greater frequency. They were also instructed to ice and rest. This is the typical “conservative care,” options that must be explored before surgery. Once these treatments failed, then the surgical discussion started.

Again, the problem with cyst draining and surgical removal of the cyst is that neither of these approaches addresses the damage that is causing the cyst to form in the first place, whether it is the damage to the meniscus, damage to ligaments, damage to the cartilage. Further, surgery involving any joint, and especially the knee, is very invasive and prone to post-surgical problems.

Doctors reporting in the medical journal Sports Health (2) wrote: “Surgical excision (removal) of the Baker’s cyst without treatment of any intra-articular lesions (tears and other damage) has been reported; however, the results have been disappointing because of the high rate of recurrence. . . The high rate of recurrence is believed to be a result of the continued presence of intra-articular pathology and associated recurrent effusions.”

  • In simple terms, the damage in the knee that is causing the swelling needs to be fixed in order to get rid of a Baker’s Cyst. If nothing gets fixed, the problem persists.


Even after Total Knee Replacement Baker’s Cysts Remain

Doctors in Germany tested the widely held belief that recurring Baker’s cyst will be cured after total knee replacement. Here are the surprising results they published in the Bone and joint journal (3).

  • After one year, a Baker’s cyst was still present in 85% of patients tested.
  • Despite a reduction in associated Baker’s cyst related symptoms from before surgery  (71%) to after surgery (31%). Of the patients who had reported Baker’s cyst associated symptoms pre-operatively, (44%) still complained of such symptoms one year after surgery.

CONCLUSION: Baker’s cysts had resolved in only a small number of patients (15%) one year after total knee replacement and symptoms from the cysts persisted in 31%.

Non-Surgical Prolotherapy for Baker’s Cysts

  • Prolotherapy is a simple regenerative medicine injection treatment.
  • Injections of dextrose, a simple sugar, is given into the knee to stimulate the immune response to repair damaged, loose weakened ligaments.
  • The concept is that the injections will help bring about stability to the knee by tightening the knee capsule.
  • The Baker’s cysts form and reoccurs in response to the body’s need to stabilize the knee and prevent hypermobility and degenerative damage by creating swelling.
  • Tighten the loose knee, correct the problems that generate the swelling, Baker’s Cysts go away and the fluid is reabsorbed into the body.

One more thing, for the Baker’s Cyst to fill up, there has to be a “port,” that allows the fluid to move into the cyst. This port can be created by the fluid’s pressure in the knee. If you remove the fluid pressure, the port closes.

Doctors in Turkey presented a case history in which they suggested Prolotherapy, specifically dextrose Prolotherapy injections diminished the size of the baker’s cyst knee by changing the “water pressure on the knee.” This is what they wrote in the Journal of Clinical and Diagnostic Research (4).

Why the dextrose? Because the dextrose had an impact on the amount of glucose in the knee. Glucose in correct amounts is necessary for wound healing. Too much glucose as seen in diabetes results in healing problems. The dextrose had a regulatory effect and created a “hypertonic” situation, that is it added to the water pressure levels of the cyst innards. Because of the added pressure, the liquid began seeping out of the cyst and back into the knee joint where regular immune system functions could remove the fluid. The Prolotherapy injections squeezed out the baker’s cyst.

Prolotherapy, stimulated the injured tissue, whether it’s the ligaments or the meniscus, to repair itself. Once repaired, the knee joint becomes more stable, which means no more joint swelling. This, in turn, means no more accumulated fluid and an end to the baker’s cyst.

PRP and Prolotherapy

  • PRP treatment takes your blood, like going for a blood test, and re-introduces the concentrated blood platelets from your blood into areas of chronic joint and spine deterioration.
  • Your blood platelets contain growth and healing factors. When concentrated through simple centrifuging, your blood plasma becomes “rich” in healing factors, thus the name Platelet RICH plasma.
  • The procedure and preparation of therapeutic doses of growth factors consist of an autologous blood collection (blood from the patient), plasma separation (blood is centrifuged), and application of the plasma rich in growth factors (injecting the plasma into the area.) In our office, patients are generally seen every 4-6 weeks. Typically three to six visits are necessary per area.

In this video, you will notice that PRP as we perform it, is NOT a single injection. It is a comprehensive treatment that addresses problems, weakness, and instability of the whole knee capsule.

If you have questions about Baker’s Cyst treatment options, get help and information from our Caring Medical staff

1 Park GY, Kwon DR, Kwon DG. Clinical, Radiographic, and Ultrasound Findings between Simple and Complicated Baker’s Cysts. American journal of physical medicine & rehabilitation. 2019 Jul. [Google Scholar]
2 Frush TJ, Noyes FR. Baker’s Cyst: Diagnostic and Surgical Considerations. Sports Health. 2015;7(4):359-365. doi:10.1177/1941738113520130. [Google Scholar]
3 Hommel H, Perka C, Kopf S. The fate of Baker’s cyst after total knee arthroplasty. Bone Joint J. 2016 Sep;98-B(9):1185-8.[Google Scholar]
4 Yavuz F, Kibar S, Balaban B. Hypertonic Dextrose Injection for The Treatment of a Baker’s Cyst. Journal of Clinical and Diagnostic Research : JCDR. 2016;10(2):YD01-YD02. [Google Scholar]


Make an Appointment |

Subscribe to E-Newsletter |

Print Friendly, PDF & Email
Find out if you are a good candidate
First Name:
Last Name:

Enter code:
Facebook Reviews Facebook Oak Park Office Review Facebook Fort Myers Office Review
for your symptoms
Prolotherapy, an alternative to surgery
Were you recommended SURGERY?
Get a 2nd opinion now!
★ ★ ★ ★ ★We pride ourselves on 5-Star Patient Service!See why patients travel from all
over the world to visit our clinics.
Current Patients
Become a New Patient

Caring Medical Florida
9738 Commerce Center Ct.
Fort Myers, FL 33908
(239) 308-4701 Phone
(855) 779-1950 Fax Fort Myers, FL Office
Chicagoland Office
715 Lake St., Suite 600
Oak Park, IL 60301
(708) 393-8266 Phone
(855) 779-1950 Fax
We are an out-of-network provider.
© 2020 | All Rights Reserved | Disclaimer
National Prolotherapy Centers specializing in Comprehensive Prolotherapy,
Stem Cell Therapy, and Platelet Rich Plasma.

Meet our Prolotherapy Doctors and check out our Prolotherapy research.