Opioids and Sexual Dysfunction

Prolotherapy Knee articular cartilage repair without surgery

Ross Hauser, MD

A new study found that 53.3% to 81.7%  of patients who were opioid dependant (addicted) had problems of sexual dysfunction.1

Two studies from the same team of Spanish researchers offer more evidence: The first study is from the Journal of Sexual Medicine. These researchers suggest:

In second study, published in February 2017 addressed the problems related to men and explored Erectile dysfunction in patients with chronic pain treated with opioids.

In this study the doctors found:

Researchers from Quinnipiac and Yale Universities recently suggested that:

The problem of long-term opioid abuse on men is significant. Harvard researchers found that even after a 14 week trial of supplemental testosterone, symptoms of pain catastrophizing or sleep quality in men was not improved.5

Please see our related article on Hormone replacement therapy and chronic pain.

Ask us your questions about this article

Ross Hauser, MD | Danielle Steilen-Matias, PA-C | Katherine Worsnick, PA-C | David Woznica, MD

1 Aggarwal N, Kherada S, Gocher S, Sohu M. A study of assessment of sexual dysfunction in male subjects with opioid dependence.  Asian J Psychiatr. 2016 Oct;23:17-23. doi: 0.1016/j.ajp.2016.06.017. Epub 2016 Jul 11. [Pubmed]

2 Ajo R, Segura A, Inda MD, Planelles B, Martínez L, Ferrández G, Sánchez A, César Margarit, Peiró AM. Opioids Increase Sexual Dysfunction in Patients With Non-Cancer Pain. J Sex Med. 2016 Sep;13(9):1377-86. doi: 10.1016/j.jsxm.2016.07.003. [Pubmed]

3 Ajo R, Segura A, Inda MD, Margarit C, Ballester P, Martínez E, Ferrández G, Sánchez-Barbie Á, Peiró AM. Erectile dysfunction in patients with chronic pain treated with opioids. Med Clin (Barc). 2017 Feb 21. pii: S0025-7753(17)30044-1. doi: 10.1016/j.medcli.2016.12.038. [Pubmed]

4. O’Rourke TK Jr, Wosnitzer MS. Opioid-Induced Androgen Deficiency (OPIAD): Diagnosis, Management, and Literature Review. Curr Urol Rep. 2016 Oct;17(10):76. [Pubmed]

5. Huang G, Travison TG, Edwards RR, Basaria S. Effects of Testosterone Replacement on Pain Catastrophizing and Sleep Quality in Men with Opioid-Induced Androgen Deficiency. Pain Med. 2016 Aug 22. [Pubmed]

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