Pes Anserine bursitis, Pes anserine syndrome, lower hamstring tendonitis, or MCL sprain

Ross Hauser, MD.,

We see many people with knee pain. More specifically we see many active people including runners with knee pain. They often have many diagnoses. Some are correct, some are not so correct. Sometimes they will display symptoms over their whole knee and not simply isolated to one area or another. However, some will have more obvious problems on one side of their knee than the other. Typically this will be more tender points on examination and obvious swelling. If these problems are on the inside of the knee towards the back of the leg, these problems may include Pes Anserine bursitis or Pes anserine syndrome.

Many people have pain seen in the inside bottom part of the knee. It can be caused by many problems beyond the Pes Anserine tendon. Typical of this and other knee pain is the pain increases with activity, swelling on the inner side of the knee may also worsen during activity.

Because there is no real telling what the knee problem is, knee MRIs will be ordered. While many patients are happy to get an MRI as they believe this will reveal what is causing their knee problem, as we will see in the research below, MRIs may confuse this knee pain problem and make the situation worse.

Discussion points of this article:

An introduction to the basic mechanisms of pes anserinus tendinopathy

The pes anserinus tendon, also known as the inside hamstring muscles, flex the knee and stabilize the inside of the knee. Most of us have very, very, very weak hamstring muscles that are very short because we sit for a large portion of our day. Many patients, especially those with fallen arches are prone to strains in these muscles. The tibia tends to rotate outward to compensate for the fallen arch. This outward rotation of the tibia places additional stress on the pes anserinus tendons. Eventually, these tendons become lax and are no longer able to control the tibial movement, adding to the chronic knee pain. Arch support may be prescribed to reestablish the arch. Pes anserine tendonitis is one of the most frequent types of knee tendonitis.

Whenever there is knee pain there are treatment options, some work, some don’t.

Whenever there is knee pain there are treatment options, some work, some don’t. The person who self manages their knee pain will try to stay active with Non-steroidal anti-inflammatory drugs (NSAIDs) for the pain and swelling. Ice and cold packs will become part of their regular day.

Eventually, a visit to the general practitioner will result in a referral to a knee specialist, and then more potent oral medications will be offered. If the swelling in the pes anserine area is more severe, then cortisone injections may be recommended. Down the line, physical therapy may be prescribed and along the way knee braces, tapes, shoe inserts, and other remedies will be tried.

It is likely that you are reading this article because your knee has not gotten better on its own and because you like to be active you have tried to manage through it. In fact, you may have felt better resuming Your sport or exercise program only to have the pain return and be a little more intense the next time it does. You are getting to the point where you need to find alternatives to your chronic knee pain.

In the image below we see the Semitendinosus tendon, gracilis tendon, and the subartorial or pes anserine bursa

In the image we see the Semitendinosus tendon, gracilis tendon, and the subartorial or pes anserine bursa 

Pes anserine syndrome or Pes Anserine tendon injury: An opinion from doctors

An opinion from doctors at the University of Florida, Orthopaedics and Sports Medicine Institute offers us a good introduction to the challenges of Pes anserine syndrome or Pes Anserine tendon injury resulting in chronic knee pain. Here are the summary highlights of this opinion. (1)

Patients with pes anserine syndrome may benefit from cortisone injections.

Pes anserine syndrome and knee osteoarthritis – a study on cortisone and physical therapy.

A July 2016 study in the Journal of Physical Therapy Science (2) looked at patients with just knee osteoarthritis and those with knee osteoarthritis and pes anserine tendino-bursitis. They wanted to compare the patient’s knee function ability in both cases.

Next, they wanted to compare treatments, specifically physical therapy and corticosteroid injection for patients with pes anserine tendino-bursitis.

Sixty patients with knee osteoarthritis and pes anserine tendino-bursitis (Group 1) and 57 patients with knee osteoarthritis but without pes anserine tendino-bursitis (Group 2) were enrolled in the study.

The pes anserine tendino-bursitis group was randomly divided into two groups (Group A and B). Physical therapy (PT) modalities were applied to the first group (Group A), and the second group (Group B) received corticosteroid injections to the pes anserine area.

Eight weeks later, patients’ pain scores were assessed.  Both treatments, Physical therapy, and corticosteroid injections resulted in significant improvements in pain and function scores, but no significant difference was detected between the [physical therapy and corticosteroid injection groups.

Findings: “Patients with pes anserine tendino-bursitis tend to have more severe pain, more altered functionality, and greater disability than those with knee osteoarthritis alone. Both corticosteroid injection and physical therapy are effective methods of treatment for pes anserine tendino-bursitis. Injection therapy can be considered an effective, inexpensive, and fast therapeutic method.

The knee is a whole joint organ made up of individual parts that make up the whole

In this section, we want to stress the concept that knee problems, especially chronic knee problems are not as simple to understand as a single component diagnosis, such as Pes Anserine bursitis or Pes anserine syndrome. Knee problems are more probably a problem of many conditions.

The knee has four major bursa. The suprapatellar, infrapatellar, pes anserine, and prepatellar. Typically knee injuries do not occur in isolation, meaning that if you injure a ligament or tendon, it was likely done with enough force or impact to cause lesser injuries to other structures.

This is pointed out by a June 2021 study (4) assessing co-injuries in patients who suffered a medial collateral ligament. In this study, the researchers found:

As you would imagine, the co-existence of this large group of co-conditions would make any diagnosis of Pes Anserine bursitis difficult to imagine as being an isolated problem.

This is also seen in the information provided to us by people looking for patient services. Often people will tell us their desire to remain active in sports, but of their current knee challenges which are the result of a long medical history.

Typically people will contact us and tell us about a Primary ACL Reconstruction, then an ACL Reconstruction Revision, and Medial Meniscus Repair. Then another meniscus surgery. They will also tell us of a subsequent injury that damaged their pes anserine.

Poor accuracy of clinical diagnosis and MRI interpretation in pes anserine tendinitis bursitis syndrome

In May 2021, doctors wrote (5) of the “poor accuracy of clinical diagnosis in pes anserine tendinitis bursitis syndrome.” What the doctors were questioning was the accuracy of clinical diagnosis as compared to MRI findings.

Typically MRI findings can be questioned for accuracy for a lower knee injury. Here the doctors compared these MRI findings to a doctor’s clinical ability to determine a pes anserine. What these researchers found was “that clinical pes anserine tendinitis bursitis syndrome diagnoses may be inaccurate, particularly in the presence of such invasive therapies as an injection, and that diagnoses based on imaging methods would be more accurate.”

The invasive injection would be a cortisone or painkiller to determine if the cause of the knee pain was found.

Would imaging be better?

In the US National Library of Medicine’s STATPEARLS (6) Updated November 2021, Mayo Clinic authors write: “Generally speaking, imaging does not assist with the diagnosis of pes anserine bursitis. However, plain knee radiographs (x-rays) are usually obtained to observe for any underlying bony abnormalities, including osteoarthritis. Ultrasonography may be used as an adjunct to evaluate other causes of localized swelling, including joint effusions. Though rarely indicated in an urgent setting, magnetic resonance imaging (MRI) may help assess for knee pathology and rule out alternative diagnoses.”

Pes Anserine bursitis may cause bone overgrowth within the thigh bone that may be misdiagnosed as a bone tumor.

Doctors at the Cleveland Clinic wrote a paper in November 2019 in the journal Skeletal Radiology (7) of the challenges an MRI may present in the accuracy of diagnosis. Here in this paper, they warn that bone changes such as the development of bone within the thigh be misinterpreted as bone cancer. “Pes anserine bursitis with intramedullary extension (bone extension inside the thigh bone) is an unusual presentation of bursitis that may simulate a neoplasm clinically and radiologically (the appearance of a bone tumor). To avoid misdiagnosis, radiologists should be aware of the occurrence of osseous changes in the tibia confluent with pes anserine bursitis.

MRI’s then too would not be considered useful in non-acute settings.

While Pes anserine syndrome is typically a problem of more active people, it can also be seen in people who had a previous knee replacement. This was demonstrated in a case history presented in the Journal of clinical orthopaedics and trauma (8) in February 2020:

Pes anserine syndrome occurs in patients with diabetes mellitus, osteoarthritis, rheumatoid arthritis, and in overweight patients. It is a challenge to identify the causes of knee pain following knee replacement surgery.

“(The authors) present a case report of pes anserine syndrome in a 79-year-old female who had undergone knee arthroplasty 13 years prior. She was pain-free until one year ago when her knee pain resurfaced without any symptoms of infection or history of trauma. She was successfully treated with a combination of stretching exercise and steroid local steroid injection. We want to highlight that such common condition as pes anserine syndrome, could occur in total knee arthroplasty, and should be considered as one of the possible diagnoses.”

Medical Treatment options

Extracorporeal shockwave therapy (ESWT) Pes Anserine

A June 2017 study in the journal Advanced Biomedical Research (9) investigated the effect of Extracorporeal shockwave therapy (ESWT) on pes anserine bursitis.

The patients in this study suffered from pes anserine bursitis for at least three months. They also had not responded to the traditional conservative methods mentioned already in this article. In total, the 40 patients of this study were divided into two 20-member experimental groups (extracorporeal shock wave therapy [ESWT] and sham ESWT).

Results: In the ESWT group, the average patient pain score as assessed by standard scoring systems was significantly lower than in the sham ESWT group immediately after intervention (3rd week) and 8 weeks after the end of treatment. The results showed that ESWT could be effective in reducing the pain and treating pes anserine bursitis.

Most Extracorporeal shockwave therapy research does not include Pes Anserine tendinopathy

Platelet Rich Plasma injections for Pes anserinus pain syndrome

A 2014 paper (10) from the Department of Orthopaedics, Military Institute of Medicine, Warsaw, Poland examined the effect of Platket Rich Plasma for Pes anserinus pain syndrome. They targeted a group of women over the age of 50. Here is what they wrote:

I personally remember coming across a classic pes anserinus case while on rounds as a new hospital doctor. A 35-year-old nurse told me her rheumatologist diagnosed her with arthritis and had prescribed anti-inflammatory medication. When he examined her knee, he found that she had a full range of motion.

Full range of motion of the knee makes it unlikely arthritis is the cause of knee pain. On further examination, I was able to elicit a positive “jump-off-her-chair sign” when I pressed my thumb into the pes anserinus area showing pes anserinus tendonitis.

When I used to give lectures and presentations, I would often ask the audience, “What is the number one reason for severe knee pain in the elderly?” The overwhelming response is arthritis. In many people we see, the number one reason for severe knee pain in the elderly is pes anserinus tendonitis which, when left untreated, may contribute to developing arthritis. Even in cases of significant arthritis, crippling knee pain is most often due to pes anserinus tendonitis or bursitis.

Prolotherapy versus local corticosteroid soft tissue injection for the treatment of chronic anserine bursitis

A September 2023 paper in the American journal of physical medicine & rehabilitation (12) compared the effectiveness of corticosteroids, oxygen-ozone (O2-O3), and dextrose 20% prolotherapy for pes anserine bursitis.  There were 72 patients in this study who were randomly assigned among the three treatment groups. Outcome measures included pain severity using the visual analog scale (VAS) and the Western Ontario McMaster Universities osteoarthritis index (WOMAC) that was evaluated before the intervention, one and eight weeks after that.

Conclusion: All three treatment options are effective for patients with pes anserine bursitis. “This study showed that the effects of O2-O3 injection and prolotherapy last longer than those of corticosteroid injection.”

Lyftogt Perineural Injection Treatment™ (also called Neurofascial Prolotherapy, as well as Neural Prolotherapy and Subcutaneous Prolotherapy) is an injection treatment sometimes used as a side-by-side treatment with traditional dextrose based Prolotherapy. As these techniques work on different aspects of knee pain, in combination they can diminish the patient’s pain

In Dextrose base Prolotherapy the ligament and tendon attachments are being treated, in Perineural Injection, the nerves are being treated.

Prolotherapy injections along the arch of the foot will also prove beneficial. Prolotherapy injections into the pes anserinus attachments to the bone strengthen the tendon attachments can resolve the chronic knee pain.

What are these injections?

Prolotherapy is a nonsurgical regenerative injection technique that introduces small amounts of dextrose to the site of painful and degenerated tendon insertions (entheses). It is injected at the tendon attachment site to the bone.

A January 2022 paper in the Ain-Shams Journal of Anesthesiology (11) examined the effectiveness of Neural prolotherapy versus local corticosteroid injection for pain relief and improvement of function in patients with chronic anserine bursitis.

The enrolled patients were randomly assigned to receive neural prolotherapy (subcutaneous perineural injection of dextrose 5% solution) (neural prolotherapy group) or a single local soft tissue injection of corticosteroid (corticosteroid group).

Outcome measures included standard pain and function outcomes and overall anserine bursitis pain severity using the visual analog scale (0-10 pain scale) and clinical assessed the presence of tenderness on the anserine bursa region. Patients were evaluated before injection and after intervention by 4 weeks.

Please see our article Tendinitis and Tendinosis treatments – Injections for Chronic Tendinopathy for more information on different injections


Pes anserine tendonitis is one of the most frequent types of knee tendonitis. The tendinosis of this structure is characterized by inflammation of the inside knee and often coexists with other knee disorders. Chronic stress from activity or contusion to the pes anserine bursa near the tibial insertion may precipitate the inflammation. An underlying ligament injury is often a coexisting problem, causing joint instability and potentially irritating the tendon as it comes in contact with the structures of the unstable knee. As with other tendinopathies, pes anserine tendonitis can be treated with Prolotherapy. Positive results have been obtained, resulting in a stabilized knee joint.

1 Sapp GH, Herman DC. Pay attention to the pes anserine in knee osteoarthritis. Current sports medicine reports. 2018 Feb 1;17(2):41. [Google Scholar]
2 Sarifakioglu B, Afsar SI, Yalbuzdag SA, Ustaömer K, Bayramoğlu M. Comparison of the efficacy of physical therapy and corticosteroid injection in the treatment of pes anserine tendino-bursitis. Journal of Physical Therapy Science. 2016;28(7):1993-7. [Google Scholar]
3 Kompel AJ, Roemer FW, Murakami AM, Diaz LE, Crema MD, Guermazi A. Intra-articular Corticosteroid Injections in the Hip and Knee: Perhaps Not as Safe as We Thought? Radiology, 2019; 190341 [Google Scholar]
4 Aguirre-Rodríguez VH, Valdés-Montor JF, Valero-González FS, Santa-María-Gasca NE, Gómez-Pérez MG, Sánchez-Silva MC, Zúñiga-Isaac C, Pérez-Mora HE, Mejía-Terrazas GE. Prevalence of injury of the medial collateral ligament of the knee assessed by magnetic resonance. Acta Ortopédica Mexicana. 2021 Nov 18;35(3):271-5. [Google Scholar]
5 Atici A, Bahadir Ulger FE, Akpinar P, Illeez OG, Geler Kulcu D, Unlu Ozkan F, Aktas I. Poor Accuracy of Clinical Diagnosis in Pes Anserine Tendinitis Bursitis Syndrome. Indian Journal of Orthopaedics. 2022 Jan;56(1):116-24. [Google Scholar]
6 Mohseni M, Graham C. Pes Anserine Bursitis. [Updated 2021 Nov 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. [Google Scholar]
7 Colak C, Ilaslan H, Sundaram M. Bony changes of the tibia secondary to pes anserine bursitis mimicking neoplasm. Skeletal Radiology. 2019 Nov;48(11):1795-801. [Google Scholar]
8 Kamudin NA, Abd Rani R, Yahaya NH. Pes anserine syndrome in post knee arthroplasty. A rare case report. Journal of clinical orthopaedics and trauma. 2020 Jan 1;11(1):171-4. [Google Scholar]
9 Khosrawi S, Taheri P, Ketabi M. Investigating the effect of extracorporeal shock wave therapy on reducing chronic pain in patients with pes anserine bursitis: a randomized, clinical-controlled trial. Advanced Biomedical Research. 2017;6. [Google Scholar]
10. Rowicki K, Płomiński J, Bachta A. Evaluation of the effectiveness of platelet rich plasma in treatment of chronic pes anserinus pain syndrome. Ortopedia, traumatologia, rehabilitacja. 2014;16(3):307-18. [Google Scholar]
11 Saba EK. Efficacy of neural prolotherapy versus local corticosteroid soft tissue injection for treatment of chronic anserine bursitis: a prospective randomized clinical trial. Ain-Shams Journal of Anesthesiology. 2022 Dec;14(1):1-0. [Google Scholar]
12 Babaei-Ghazani A, Eftekharsadat B, Soleymanzadeh H, ZoghAli M. Ultrasound Guided Pes Anserine Bursitis Injection Choices; Prolotherapy or Oxygen-Ozone or Corticosteroid: A Randomized Multicenter Clinical Trial. American Journal of Physical Medicine & Rehabilitation. 2023 Sep 27. [Google Scholar]


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