Caring Medical - Where the world comes for ProlotherapyComparing Injection treatments for Plantar fasciitis, Plantar Fasciopathy and Plantar fasciitis tears

Ross Hauser, MD  | Caring Medical Regenerative Medicine Clinics, Fort Myers, Florida
David N. Woznica, MD | Caring Medical Regenerative Medicine Clinics, Oak Park, Illinois
Katherine L. Worsnick, MPAS, PA-C  | Caring Medical Regenerative Medicine Clinics, Fort Myers, Florida
Danielle R. Steilen-Matias, MMS, PA-C | Caring Medical Regenerative Medicine Clinics, Oak Park, Illinois

Comparing Injection treatments for Plantar fasciitis, Plantar Fasciopathy and Plantar fasciitis tears

When we see patients who have continued problems with plantar fasciitis, we usually see patients who:

  • Are runners or athletes who have been struggling with and trying to manage their plantar fasciitis for months, maybe years.
  • Have already tried numerous variations of self-help and physio work including:
    • Rolling a ball with the sole of their foot
    • Rolling a bottle of frozen water with the sole of their foot
    • Varying foot, Achilles, and calf stretches
    • Various braces and taping
    • Various splints and shoe inserts
    • Boots
    • Changing shoes
    • Massages
    • Stopped running
    • Limited walking
    • Lots of anti-inflammatory medications

Moving on to injections for Plantar fasciitis

For many people, these things can be very helpful and even make the Plantar fasciitis go away entirely or for the most part. Unfortunately, for the patients we see, this stuff did not work. They came to our clinics because they become “difficult to treat plantar fasciitis patients,” and were being suggested to a cortisone injection or other infection treatments. We do see patients who have had a cortisone injection, it may have worked for them for some time, but the plantar fasciitis returned. So what do you do?

We want to begin this article by going right into a new study that will help us understand injection treatments for Plantar fasciitis.

It is published in The Journal of Foot and Ankle Surgery (1) and it comes from medical university researchers in Turkey.

Comparing the therapeutic effects of extracorporeal shock wave therapy, platelet-rich plasma injection, local corticosteroid injection, and prolotherapy for the treatment of chronic plantar fasciitis

There is so much here in this article we can share that can help you understand your treatment options. So let’s get to it.

Research highlights:

  • The researchers performed a randomized controlled prospective clinical study of 4 groups.
    • The first group received extracorporeal shock wave therapy, (electric pulse therapy)
    • the second group received prolotherapy, (simple dextrose injections)
    • the third group received platelet-rich plasma injection, (injections of the patient’s blood platelets)
    • and the fourth group received a local corticosteroid injection.
  • The study included 158 consecutive patients with a diagnosis of chronic plantar fasciitis with a symptomatic heel spur.
  • The clinical outcomes were assessed using the visual analog scale (a pain scoring scale of 0-10) and Revised Foot Function Index (A questionnaire about foot disability and discomfort).

The Results:

  • The corticosteroid injection was more effective in the first 3 months but then its effectiveness all but disappeared
  • The extracorporeal shock wave therapy was an effective treatment method in the first 6 months in regard to pain.
  • The effect of prolotherapy and platelet-rich plasma was seen within 3 to 12 months; however, at the 36-month follow-up point, no differences were found among the 4 treatments.

This study hits on many points that can help explain why cortisone and extracorporeal shock wave therapy are not long-term treatment options for chronic plantar fasciitis and how PRP and prolotherapy treatments provide longer relief. This study also gives us the ability to point out helpful treatment guidelines for you towards a more permanent solution to your foot pain.

Treatments with short-term or little relief value vs treatments with long-term value

It is easy to understand why a patient with chronic plantar fasciitis are frustrated. They are often given treatments that provide short-term relief but hurt their chances of long-term relief and the ability to return to activity.

  • The first line of treatment is usually to recommend cutting back on the activity that is causing the pain.
  • Massaging the foot with a tennis ball and application of ice are commonly recommended.
  • Inject steroids (see above) into the foot or to prescribe anti-inflammatory medications in order to relieve the pain associated with the weakened plantar fascia.
  • Shock wave therapy is often suggested.
  • Often taping, orthotics, and night splints are used as well.

Cortisone shots and anti-inflammatory drugs have been shown to produce short-term pain relief benefit, but both result in long-term loss of function and even more chronic pain by actually inhibiting the healing process of soft tissues and accelerating cartilage degeneration. For example, cortisone will eventually weaken the fascia. If they are not strengthened, a painful heel spur will result.

Dry Needling better than cortisone

A March 2019 study in The Journal of Foot and Ankle Surgery (2) suggested that dry needling would be as effective as the use of corticosteroid injections for treating Plantar fasciitis. The additional benefit would be avoiding the potential adverse effects of corticosteroids. To prove the point, the researchers of this study took patients diagnosed with Plantar fasciitis and prescribed them a 3-week nonoperative treatment regimen.

First two weeks of the program:

  • First, the patients in the study were prescribed oral and topical anti-inflammatory drugs and gastrocnemius (calf) stretching exercises.
  • After two weeks of anti-inflammatories and stretching, the patients who did not have pain relief and required further treatment were now moved onto the comparison study between cortisone and dry needling,

The patients were divided into 2 groups

  • Group 1 underwent dry needling, and
  • group 2 underwent corticosteroid injection.

Patients were assessed in the third week and sixth month.

  • In terms of foot function index scores, dry needling caused a significant decrease in the third week and also in the sixth month.
  • However, although corticosteroid use led to a significant decrease at the third week, it lost efficacy in the sixth month.
  • In conclusion, dry needling seems to be a reliable procedure for treating Plantar fasciitis, with better outcomes than corticosteroid injection.

Dry needling in a needle with no medication.

Plantar Fasciopathy Research – Why is Cortisone still an option?

As in the study above, researchers are constantly trying to prove the effectiveness of one treatment over another to answer the simple question: What treatments work best for Plantar fasciitis and chronic plantar fasciopathy (disease of the plantar fascia)?

Researchers at the University of Northern Iowa wrote in the Journal of Sports Rehabilitation:

“For active individuals, plantar fasciitis is one of the most clinically diagnosed causes of heel pain. When conservative treatment fails, one of the next most commonly used treatments includes corticosteroid injections. Although plantar fasciitis has been identified as a degenerative condition, rather than inflammatory, corticosteroid injection is still commonly prescribed. . . “(3They also concluded that PRP injections would be more effective a choice of treatment.

Doctors writing in the medical journal Rheumatology compared the effectiveness of a number of treatments. This included Platelet Rich Plasma Therapy, shock-wave therapy, and corticosteroid injection.

The researchers discovered a trend that favored the PRP treatment. They noted that Platelet Rich Plasma Therapy, followed by shock-wave therapy, were best in providing relief from pain at 3 months over cortisone. Shock-wave therapy and PRP had similar probabilities of providing pain relief at 6 months.(4)

Doctors in the United Kingdom published comparative research for platelet-rich plasma versus corticosteroid injections in treating plantar fasciopathy. Writing in the journal International Orthopaedics, the UK researchers noted: PRP injections are associated with improved pain and function scores at three-month follow-up when compared with corticosteroid injections.(5)

Cortisone no better than placebo for restoring function?

This is an August 2019 study from medical university researchers in Australia published in the journal BioMed Central musculoskeletal disorders.(6) Here are the learning points of this study:

  • Corticosteroid injection is frequently used for plantar heel pain (plantar fasciitis), although there is limited high-quality evidence to support this treatment.
  • For reducing pain in the short term, corticosteroid injection was more effective than autologous blood injection and foot orthoses.
  • There were no significant findings in the medium term.
  • In the longer term, corticosteroid injection was less effective than dry needling and platelet-rich plasma injection.
  • Notably, corticosteroid injection was found to have similar effectiveness to placebo injection for reducing pain in the short and medium terms.
  • For improving function, corticosteroid injection was more effective than physical therapy in the short term.
  • Corticosteroid injection is not more effective than placebo injection for reducing pain or improving function. 

The beneficial effect of prolotherapy and platelet-rich plasma was seen within 3 to 12 months

Plantar Fasciopathy Research – Why are we still thinking PRP is a “one-shot wonder?”

Most times studies on PRP effectiveness even the favorable ones – rely on a single dose treatment and a hope for a “one-shot” wonder. For many suffering from chronic plantar fasciitis, one-shot wonders typically do not provide the more permanent relief the patient is looking for. But as this study points out the potential for PRP is great – when administered by an experienced provider.

As in the above study, doctors writing in British Medical Bulletin evaluated the evidence for platelet-rich plasma injection as a treatment for chronic plantar fasciopathy. What they found was PRP for treating chronic plantar fasciopathy shows promising results, and appears safe. However, the number of studies available is limited to give definite positive results and they would like to see more studies performed.(7)

In other research, doctors say they can’t tell if PRP works because there is no standardized treatment technique and that based on “one-shot wonders” it doesn’t appear to be effective over other treatments.(8) Enough so that some researchers want cortisone under ultrasound guidance restored as the primary treatment for plantar fasciitis,(9despite conflicting research as reported above and here:

Recent research contradicts that sentiment of restoring cortisone as a primary treatment for plantar fasciopathy. Doctors in the UK say “PRP is as effective as Steroid injection at achieving symptom relief at 3 and 6 months after injection, for the treatment of plantar fasciitis, but unlike Steroid, its effect does not wear off with time. At 12 months, PRP is significantly more effective than Steroid, making it better and more durable than cortisone injection.”(10)

Further research in the Singapore medical journal suggests it is evident that the effects of corticosteroid injections are usually short-term, lasting 4-12 weeks in duration. Complications and side effects such as plantar fascia rupture are uncommon, but physicians need to weigh the treatment benefits against such risks.(11)

Prolotherapy or PRP for plantar fasciitis?

Prolotherapy, like PRP, repairs plantar fasciitis by strengthening the fascia and providing support to the arch of the foot. Prolotherapy is a treatment that regenerates and strengthens the weakened structures, such as the weakened plantar fascia ligament.

When a patient comes in with plantar fasciitis, an evaluation is made as to what type of treatments will likely benefit the patient most. Often times we will look for the simplest treatment. In many cases, simple dextrose Prolotherapy will do the trick. Sometimes a stronger proliferant solution like PRP is required.

Korean doctors writing in PM & R: the journal of injury, function, and rehabilitation compared Prolotherapy to PRP in the treatment of chronic recalcitrant plantar fasciitis. Led by the Korea National Sports University, the researchers found all patients in both the Prolotherapy group and the PRP group showed significant improvements. They concluded: “Each treatment seems to be effective for chronic recalcitrant plantar fasciitis, expanding the treatment options for patients in whom conservative care has failed. PRP treatment also may lead to better initial improvement in function compared with dextrose Prolotherapy treatment.”(12)

Prolotherapy treatments need to focus on the spring ligament which is also called the plantar calcaneonavicular ligament. This is one of the most important ligaments in the arch that supports the arch. But whether someone has a high arch, normal arch, or flat arch, or pes planus, if they have pain and tenderness to palpation, typically they’ll respond great to Prolotherapy because Prolotherapy stimulates the repair of the injured areas. It causes the proliferation of injured soft tissue so they repair.

Plantar fasciitis is more of a misnomer since “itis” means inflammation, and most patients who have been diagnosed with plantar fasciitis actually have a weakened, degenerated plantar fascia.

True inflamed tissue is hot to the touch, red, and swollen. Thus, the anti-inflammatory treatments do not promote repair and healing of the fascia because most cases of this type of foot pain are not truly inflammatory.

Now that the evidence for PRP and Prolotherapy over cortisone has been presented, let’s go back and discuss the problem of plantar fasciitis.


Plantar fasciitis | Plantar Fasciopathy

The relationship between plantar calcaneal spur (Heel Spurs) and Plantar fasciitis

Plantar fasciitis is one of the most common causes of heel pain. Plantar fasciitis involves pain and inflammation of the plantar fascia, a flat band of tough tissue supporting the arch of the foot that runs from the heel to the base of the toes. It looks sort of like a series of fat rubber bands, but the plantar fascia is made of collagen which is rigid and non-stretchy. Plantar fasciitis is common in middle-aged people but also occurs in younger people who are on their feet a lot. When the plantar fascia is strained, it becomes weak, swollen, and irritated.

Repeated microscopic tears of the plantar fascia cause pain that is most notable in the morning after getting out of bed. Putting weight on the injured area after periods of rest (such as sleep) will cause stress on the area and a more sudden, aching pain.  Once the foot loosens up, the pain generally decreases. The pain may return, however, after long periods of standing, or after another period of rest. Plantar fasciitis may also be called “heel spurs,” but this is not always accurate because bony growths on the heel may or may not be involved.

In the medical journal Foot and Ankle Injury(13) doctors in the United Kingdom point out the confusion foot specialists face when understanding the relationship between a heel spur and plantar fasciitis. Here is what they write:

  • Plantar fasciitis is a common diagnosis in patients presenting with heel pain.
  • The presence of co-existing calcaneal spurs has often been reported but confusion exists as to whether it is a casual or significant association. (In other words, does plantar fasciitis cause heel spurs?)

So how did this research team come up with the answer? By comparing soft tissue ligament instability. Does weakness in the soft tissue cause bone spur formation. Our website is filled with research that it does, of course, do so.

This is what the researchers did:

  • They looked at lateral heel radiographs of nineteen patients with a diagnosis of plantar fasciitis and nineteen comparison subjects with a lateral ankle ligament sprain matched for age and sex, were reviewed independently by two observers.
  • There was a significantly higher prevalence of heel spurs in the plantar fasciitis cases than the comparison group (89% versus 32%.)

Studies like these give fantastic examples of the problems of joint instability and the body’s way of dealing with it at the point of the problem.

  • Both the lateral ankle ligament sprain and the plantar fasciitis would cause pain and instability in the heel region.
  • However, the way to stabilize the heel when plantar fasciitis was the problem was to grow a heel spur, albeit a painful one in 89% of the patients. When the ankle was the problem, the body grew a heel spur 32% of the time. The other two-thirds of incidence, the body figured out a different way of dealing with the chronic ankle sprain and instability– chronic inflammation.

Note: Heel spurs are due to weakened ligamentous support of the plantar fascia. Prolotherapy to strengthen the plantar fascia will eliminate chronic heel pain. There is generally not a need for heel spurs to be surgically removed after the supportive ligaments and plantar fascia have been repaired.

Foot instability

Then again, some people with heel spurs have heel pain, some people with heel spurs have no heel pain. Is the presence of the heel spur confusing the treatment options?

Doctors at the University of Auckland and the Department of Orthopedic Surgery, Wellington Hospital in New Zealand published a comprehensive opinion on how to treat heel spurs. This paper was published in the Journal of Anatomy. (14)

  • At the top the researchers noted that they had examined, (as we have here) patients with plantar calcaneal (heel) spurs who had significant pain episodes. The doctors also examined patients (as we have here) who have heel spurs that cause no pain at all. Also, heel spurs are present in 45–85% of patients a diagnosis of plantar fasciitis. (Again, heel spurs are common, many do not cause pain).

Prolotherapy Specialists plantar fasciitis

If you have questions about plantar fasciitis, get help and information from our Caring Medical staff

1 Uğurlar M, Sönmez MM, Uğurlar ÖY, Adıyeke L, Yıldırım H, Eren OT. Effectiveness of Four Different Treatment Modalities in the Treatment of Chronic Plantar Fasciitis During a 36-Month Follow-Up Period: A Randomized Controlled Trial. The Journal of Foot and Ankle Surgery. 2018 Sep 1;57(5):913-8. [Google Scholar]
2 Uygur E, Aktaş B, Eceviz E, Yilmazoğlu EG, Poyanli O. Preliminary Report on the Role of Dry Needling Versus Corticosteroid Injection, an Effective Treatment Method for Plantar Fasciitis: A Randomized Controlled Trial. The Journal of Foot and Ankle Surgery. 2019 Mar 1;58(2):301-5.
3 Karls SL, Snyder KR, Neibert PJ. Effectiveness of Corticosteroid Injections in the Treatment of Plantar Fasciitis. J Sport Rehabil. 2016 May;25(2):202-7. doi: 10.1123/jsr.2014-0234. [Google Scholar]
4. Hsiao MY, Hung CY, Chang KV, Chien KL, Tu YK, Wang TG. Comparative effectiveness of autologous blood-derived products, shock-wave therapy and corticosteroids for treatment of plantar fasciitis: a network meta-analysis. Rheumatology (Oxford). 2015 Apr 6. [Google Scholar]
5 Singh P, Madanipour S, Bhamra JS, Gill I. A systematic review and meta-analysis of platelet-rich plasma versus corticosteroid injections for plantar fasciopathy. Int Orthop. 2017 Jun;41(6):1169-1181. [Google Scholar]
6 Whittaker GA, Munteanu SE, Menz HB, Bonanno DR, Gerrard JM, Landorf KB. Corticosteroid injection for plantar heel pain: a systematic review and meta-analysis. BMC musculoskeletal disorders. 2019 Dec;20(1):1-22. [Google Scholar]
7 Franceschi F, Papalia R, Franceschetti E, et al. Platelet-rich plasma injections for chronic plantar fasciopathy: a systematic review. Br Med Bull. 2014 Sep 19. pii: ldu025.  [Google Scholar]
8 Sandrey MA. Autologous growth factor injections in chronic tendinopathy. J Athl Train. 2014 May-Jun;49(3):428-30. doi: 10.4085/1062-6050-49.3.06. Epub 2014 May 19 [Google Scholar]
9. Kirkland P, Beeson P. Use of primary corticosteroid injection in the management of plantar fasciopathy: is it time to challenge existing practice? J Am Podiatr Med Assoc. 2013 Sep-Oct;103(5):418-29. [Google Scholar]
10 Jain K, Murphy PN, Clough TM. Platelet rich plasma versus corticosteroid injection for plantar fasciitis: A comparative study. Foot (Edinb). 2015 Aug 22. pii: S0958-2592(15)00083-8.  [Google Scholar]
11 Ang TWA. The effectiveness of corticosteroid injection in the treatment of plantar fasciitis. Singapore Medical Journal. 2015;56(8):423-432. [Google Scholar]
12 Kim E, Lee JH. Autologous platelet-rich plasma versus dextrose prolotherapy for the treatment of chronic recalcitrant plantar fasciitis. PM&R. 2014 Feb 28;6(2):152-8. [Google Scholar]
13 Johal KS, Milner SA. Plantar fasciitis and the calcaneal spur: Fact or fiction?. Foot and Ankle Surgery. 2012 Mar 31;18(1):39-41. [Google Scholar]
14 Kirkpatrick J, Yassaie O, Mirjalili SA. The plantar calcaneal spur: a review of anatomy, histology, etiology and key associations. J Anat. 2017 Jun;230(6):743-751. doi: 10.1111/joa.12607. Epub 2017 Mar 29. PubMed PMID: 28369929; PubMed Central PMCID: PMC5442149. [Google Scholar]


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