Platelet Rich Plasma for Knee Osteoarthritis | When PRP will work and when PRP will not work
In this article, we are updating research and clinical observations in the use of Platelet Rich Plasma Therapy (PRP) for the treatment of knee osteoarthritis. We will also explain why PRP may not work and how getting a single PRP injection is NOT PRP Therapy and will usually lead to unsatisfying long-term results.
Research is now moving away from trying to prove or not prove out Platelet Rich Plasma Therapy as being an effective treatment for knee osteoarthritis. PRP does work – this has been made clear by the mounting evidence from independent medical researchers.
Part of that evidence is a study published in the American medical journal Arthroscopy. Here doctors from Chongqing Medical University in China suggested that PRP injections were more effective in the treatment of knee osteoarthritis, in terms of pain relief and self-reported function improvement at three, six, and twelve months follow-up, compared with other injections. These injections included saline placebo, Hyaluronic Acid, ozone (see our article on Prolozone), and corticosteroids. Further, they found that PRP did not increase the risk of adverse events compared with Hyaluronic Acid and saline.(1)
“PRP did not work for me, why?”
Often will get emails from people who have had previous PRP treatment. They will tell us that they did not have the success they were hoping for and had been anticipating. The treatment had failed them.
We then ask this person to describe the treatment they received, they usually describe this:
- PRP injection was recommended after MRI showed degenerative condition.
- After examining the image, the doctor then determined where to give the shot.
- One shot given.
- On follow up some improvement.
- As weeks progressed, treatment ineffective.
The pitfalls of basing success of treatment on a single injection of Platelet Rich Plasma Therapy are many. Some physicians may use PRP as a single dose treatment rather than as part of a comprehensive knee osteoarthritis treatment program. Used this way, as single dose, PRP may not be as effective. As mentioned, the typical person reporting this treatment to us will still report that they had good success initially but then the effect began to wear off.
Research: It is not the PRP, it is the way PRP is given that leads to successful treatment or failed treatment
Now read what University researchers in Mexico published in the journal Cirugía y cirujanos (Surgery and Surgeons)
- The biological changes that commonly cause degenerative articular cartilage injuries in the knee are primarily associated to misalignment of the joint and metabolic changes related to age, as occurs in osteoarthritis.
- (Note: Degenerative and destructive forces are acting on the knee causing it to misshape and become unstable. The metabolic changes are the body’s inability to heal this damage. Please watch the video with Dr. Hauser below for an explanation)
- The number of publications demonstrating the therapeutic and regenerative benefits of using platelet-rich plasma as a treatment for knee osteoarthritis has been increasing in recent years. In spite of encouraging results, there are still only a few randomised control studies with strong clinical evidence, lacking clarity on points such as the optimum formulation
- Up to this point and based on the results of clinical studies, not all patients can benefit from this therapy.(2)
- PRP is effective for knee osteoarthritis
- PRP is not effective for all patients, there may be too much damage or the treatment was not sufficient. Problem: There is no “optimum formulation”
So when someone walks into an office for PRP treatment, if that office practices single shot injections, will this treatment be effective? Likely no
When PRP is injected at a single location within the damaged knee, it goes right to work to patch and fix the damage. BUT PRP CANNOT sustain this fix if the same elements that caused the degenerative knee condition are allowed to damage the newly healed tissue.
If this person were to come into our office, we would explain that single shot PRP may only be a temporary heal because it did not address what was causing the damage, knee instability. You recognize instability as a loose, wobbly knee that feels like it could give way even when you are standing still. One shot of PRP can patch a cartilage, it cannot stabilize the entire knee. Dr. Hauser explains this in detail in this short video.
When treating the knee, our medical team utilizes a Comprehensive Prolotherapy injection technique which may include a combination of healing factors. PRP is commonly used in conjunction with Dextrose Prolotherapy and Stem Cell Therapy. If stem cells are used, they would be drawn from the patient and then re-injected into the knee to stimulate tissue regrowth, such as in instances of knee osteoarthritis. This is to ensure that a more thorough treatment is given to the weakened area, versus a one-shot PRP approach. Please see this article for a discussion on the general treatment of osteoarthritis including a detailed description of the PRP therapy injections and for a comparison of types of knee osteoarthritis injection treatments including Prolotherapy.
In this brief video, Dr. Hauser demonstrates PRP to the supportive ligaments of the knee. PRP injections have the blood red color. He is also demonstrating Prolotherapy injections to support the PRP injections. The Prolotherapy injections are clear in color.
The pain relief from PRP, is it symptom relief like a cortisone injection gives, or is it pain relief because healing has occurred? Number of PRP injections needed how long is recovery?
Frequently patients will ask: What is the healing or recovery time with PRP?
The research mentioned above on the need to standardize how the PRP treatment shows that patients do get relief. But what kind of relief? Is symptom relief similar to what a cortisone injection gives, or is it pain relief because healing has occurred?
Researchers looked at 78 patients with bilateral knee osteoarthritis. The patients were then divided randomly into three groups.
- Group A (52 knees) received a single injection of PRP.
- Group B (50 knees) received 2 injections of PRP 3 weeks apart.
- Group C (46 knees) received a single injection of normal saline.
The three groups were compared with each other and no improvement was noted in group C as compared with groups A and B.
If you give a single shot of PRP twice and 3 weeks apart, is that better? No
The next part is interesting: there was no difference between groups A (Single one-time injection) and B (Single injection – two times three weeks apart), which means that a single dose of PRP is as effective as two injections to alleviate symptoms in early knee osteoarthritis. The results, however, deteriorate after six months. Both groups treated with PRP had better results than did the group injected with saline only.
Other than the fact that the PRP was found effective at alleviating symptoms of osteoarthritis in the knee is the subsequent findings. Two PRP injections were no more effective than one and that the results deteriorated after six months.(3)
Now these findings are somewhat in agreement with other recent research that suggests a single dose of PRP worked very well for a six-month time period but the results deteriorated.(4)
How about three injections two weeks apart, is that better?
Doctors in Turkey publishing in the Journal of physical therapy science, assessed PRP applications in a group of patients in their mid-50’s. Three groups were selected for PRP injections.
- Group 1 received a single injection of PRP,
- Group 2 received two injections of PRP two weeks apart,
- Group 3 received three injections of PRP at 2-weeks intervals.
Statistically significant improvements were noted in all of the evaluated measures in all of the groups. There was significant improvement in the 3 injection group.(5)
Yes. Doctors are confirming the more PRP injections the better the result. This is why we give the injection at more than one location in one treatment.
Now that we have examined the evidence that PRP works better as part of a comprehensive whole knee treatment, we can now get about the business of seeing how it works and compare it to other types of treatments
The basics behind how PRP works for knee osteoarthritis is summarized in research from doctors at the University of California. In their study in the publication Tissue engineering. Part B, Reviews, the doctors suggest that PRP injections cause positive, beneficial, and healing cellular changes in the joint environment. These changes help move the knee from degenerative knee disease to a healing and regenerating knee joint. Healing includes: regeneration of articular cartilage, increasing the volume of natural knee lubricants, and waking up the stem cells present in the knee to assist in the transformation to healing environment.(6)
In the present study, the researchers wrote: PRP modulates the repair and regeneration of damaged articular cartilage in the joints and delays the degeneration of cartilage by stimulation of mesenchymal stem cell migration, proliferation, and differentiation into articular chondrocytes (the cells of cartilage).
- What this last sentence means is that stem cells in the knees, responsible for repair on many levels, migrate because PRP call them to the site of the injury, proliferate – make more of themselves, differentiate – change themselves into cartilage. The stem cell therapy process is explained at length in our article Stem Cell Therapy for Knee Osteoarthritis and Cartilage Regeneration.
In addition, PRP reduces the pain by decreasing inflammation of the synovial membrane where pain receptors are localized. Synovial membrane is a protective layer of connective tissue that is also responsible for creating synovial fluid that lubricates the joints.
Is PRP a better knee lubricant than hyaluronic acid?
As amazing as the above research is – it is another in the progression of studies. Previously in 2015, the same University of California Davis researchers speculated that PRP provided the lubrication needed to protect the cartilage. The study researchers summarized that intra-articular injections of PRP have the potential to relieve the symptoms of osteoarthritis in the knee and that there is an influence on superficial zone protein (SZP) which is a boundary lubricant in articular cartilage and plays an important role in reducing friction and wear and therefore is critical in cartilage regeneration.(7)
In other words, PRP is acting like hyaluronic acid, except it is healing and regenerating the knee which hyaluronic acid is not designed to do – please see that article where we also discuss the combined use of hyaluronic acid and PRP for knee osteoarthritis.
The second Chinese study, published in the Orthopaedic surgery and research out of London also suggested that current evidence indicates that, compared with Hyaluronic Acid and saline, intra-articular PRP injection may have more benefit in pain relief and functional improvement in patients with symptomatic knee osteoarthritis at 1 year postinjection.(8)
Doctors in Thailand published in slightly earlier research that PRP injection improved patient symptoms and function when compared to Hyaluronic Acid and placebo suggesting that PRP injection is more effective than Hyaluronic Acid injection and placebo in reducing symptoms and improving function and quality of life. (9)
In the medical journal Arthroscopy, the Journal of Arthroscopic and Related Surgery, research sought to answer Does Intra-articular Platelet-Rich Plasma Injection Provide Clinically Superior Outcomes Compared With Other Therapies in the Treatment of Knee Osteoarthritis?
This study examined previously published studies and concluded that PRP injections are a viable treatment for knee osteoarthritis and has the potential to lead to symptomatic relief for up to 12 months.(10) The researchers also speculated that PRP may have worked better had the patient received multiple PRP injections. PRP is not a one-shot therapy
In the accompanying editorial James H. Lubowitz, MD writes, “(the authors) pose a controversial question and ultimately conclude that platelet-rich plasma (PRP) is a valuable treatment for knee osteoarthritis.
Osteoarthritis pain is epidemic, biologics hold promise, pain research is limited to some extent by the placebo effect, and the ultimate goal must be chondroprotection, or even cartilage restoration, in addition to symptomatic relief. That said, PRP injection does result in improved knee pain and function in patients with osteoarthritis.”(11)
PRP, hyaluronic acid and placebo.
- In September 2015, doctors writing in the medical journal Arthroscopy suggested that platelet-rich plasma (PRP) injection significantly improved patient-reported outcomes in patients with symptomatic knee osteoarthritis at 6 and 12 months postinjection and that PRP was superior to hyaluronic acid injections or viscosupplementation and placebo injections.(12)
Is PRP better anti-inflammatory than Cortisone?
In this study, a comparison is made between the effects of a one-time injection of PRP and corticosteroid (cortisone shot) for the patients suffering from osteoarthritis.
Patients suffering from Grade II or Grade III knee osteoarthritis were randomly divided into two groups: intra articular injection of PRP and cortisone.
Forty-one participants (48 knees) were involved in the research (66.7% women with and average age of 61).
Compared to the group treated with corticosteroid, PRP showed significant results for:
- pain relief
- being symptom free,
- activities of daily living and quality of life
But sporting ability was not different between the 2 groups. PRP prescription was significantly more helpful for relieving patients’ pain compared to corticosteroids .It’s also notable that using PRP was more helpful in improving the 20-meter-walk test than corticosteroid treatment but none of the treatments had any impact on active flexion Range of Motion ،passive flexion Range of Motion and flexion contracture.
This study demonstrated that one shot of PRP injection, decreased joint pain more and longer-term, alleviated the symptoms, and enhanced the activity of daily living and quality of life in short-term duration in comparison with corticosteroid.(13)
A 2017 study in the American Journal of Sports Medicine lead by Brandon Cole MD of Rush University Medical Center found PRP was involved in decreasing 2 proinflammatory cytokines, which suggest that the anti-inflammatory properties of PRP may contribute to an improvement of symptoms.(14) The difference of course is that you can offer more than one PRP injection or combine it with comprehensive Prolotherapy for knee osteoarthritis to gain better results. Typically a doctor will not recommend multiple corticosteroid injection because of the negative effects.
How does PRP compare to Ozone Therapy?
In research from February 2017, Turkish researchers publishing in the medical journal Knee surgery, sports traumatology, arthroscopy compared treatment effectiveness in patients with knee osteoarthritis given an intra-articular injection of platelet-rich plasma, hyaluronic acid or ozone gas.
A total of 102 patients with mild-moderate and moderate knee osteoarthritis were chosen who had at least a 1-year history of knee moderate pain (a four out of 10 pain rating or worse)
- Group 1 (platelet-rich plasma group) received intra-articular injection of PRP × 2 doses,
- Group 2 (hyaluronic acid group) received a single dose of hyaluronic acid,
- and Group 3 (Ozone group) received ozone × four doses.
- At the end of the 1st month after injection, significant improvements were seen in all groups.
- In the 3rd month, the improvements were similar in platelet-rich plasma group and hyaluronic acid group , while those in Ozone group were lower.
- At the 6th month, while the clinical efficacies of platelet-rich plasma and hyaluronic acid were similar and continued, the clinical effect of ozone had disappeared
- At the end of the 12th month, platelet-rich plasma was determined to be both statistically and clinically superior to hyaluronic acid.(15)
We hope you found the message oif thjis article information.
- In our experience, we have found single injections of PRP are note effective long-term
- In our experience we have found comprehensive treatments including injecting to treat cartilage damage as well as ligament weakness provides the knee teh best chance of healing
- In our experience, experience and the number of procedures the health care provider has, the better the out come.
If you have questions about Platelet Rich Plasma Therapy for Knee Osteoarthritis, get help and information from our Caring Medical staff
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