PRP shoulder injections comparing cortisone to other injections

Ross Hauser, MD, Danielle Steilen-Matias, PA-C

Typically a person will contact us with questions about their shoulder surgery recommendations following multiple cortisone injections and no noticeable improvement in their situation. For most, no noticeable improvement actually means accelerated deterioration of their shoulder situation.

The story these people tell is probably very familiar to some of your stories. We have the “masters athlete” enjoying retirement or close to retirement age that likes to play pickleball, golf, and stay active. Unfortunately, they now find that they have difficulty going overhead during a tennis serve, serves are now side-armed. The golf swing has been altered, baseball or softball throws are now side armed or even underhanded. Swimming with their shoulder pain is very difficult and can only be accomplished with an alternate method swimming stroke.

We also have a person with a physically demanding job who has to stay on the job and needs anything that can help them. These are the people who have not developed into later stages of osteoarthritis yet, meaning that they have not been recommended to shoulder replacement, but they may have been recommended for arthroscopic surgery because their rotor cuff is frayed and torn up.

What both these types of people may have in common is a history of cortisone injection into the shoulder spaced four to six months apart. Both of these types of people may have found that the first cortisone injection helped, sometimes it helped a little, sometimes it helped a lot, but the injection helped enough to justify a second cortisone injection a few months later. What both these people types may also have in common is the second cortisone injection’s effects wore off after a week or two. Following this, both of these people may find themselves continuing their daily routine of ice, anti-inflammatories, and a cream or ointment, to help stay active. The recommendation for shoulder replacement has been made. Can they avoid the surgery with PRP?

When someone contacts our office with this type of problem we discuss with them their range of motion. If there is a lot of bone spurs, they typically have a significant reduction in their range of motion because of bony overgrowth, not just because of pain, PRP or any conservative care will not restore that range of motion. Surgery will be necessary. If the shoulder’s range of motion is limited because of soft tissue damage and there is little evidence of boney overgrowth or bone spurs. Then PRP injections may help.

We are going to limit this article’s subject to PRP and cortisone injections. On our website, we have some comprehensive articles on shoulder surgery. They are:

Also see our article: Treating bone spurs in the shoulder is difficult. Even with surgery.

Cortisone because my problem is inflammation

The recommendation that you get cortisone injection is based on the diagnosis that you have inflammation. The inflammation is significant enough that is causing pain on movement and the extra fluid in your shoulder is impeding your ability to have a full or close to the full range of arm motion.

Here are some familiar tales:

I’ve been dealing with shoulder pain for over five years. I recently had a dye injected MRI and it showed inflammation. I’ve had a cortisone shot which did not help me at all. I’ve also gone to physical therapy for six weeks which also did not help. I have trouble sleeping some nights because the pain will keep me awake. My range of motion is affected by this but it’s a constant aching pain that gets worse with repetitive motion.

In a situation like this, where the person has a good range of motion PRP would be considered beneficial. Generally speaking that the cortisone was not effective is indicative that inflammation was not the primary problem.

I injured my shoulder at the gym. An orthopedic physician told me that I had bursitis and had a cortisone shot. It lasted only about a month. I’ve been going to a massage therapist but am still having issues twisting my arm and sometimes raising it.

In a situation like this, inflammation-causing bursitis and limited range of motion returned after a month because the issue is not bursitis or inflammation but soft tissue damage in the shoulder. PRP would be considered beneficial for someone like this.

I am having pain in my shoulder at the AC joint due to narrowing of this joint space – my orthopedic surgeon is suggesting surgery to shave the bone and eliminate the “rub” between the bones. Would PRP be a treatment option for the shoulder AC joint? My surgeon also suggested a cortisone shot to reduce the inflammation.

In this situation, shoulder instability may cause rub and inflammation. PRP can be helpful. This is a more complicated case and we describe AC joint problems in our article Chronic shoulder dislocation, subluxation, and shoulder instability.

I have been diagnosed with a frozen shoulder. Had a cortisone shot, and I am doing PT sessions, but have the feeling it won’t work and I will end up in surgery. Four years ago, I had a frozen shoulder on the other side, and ended up in surgery, even though I had done the cortisone shot and the physical therapy. Will PRP work?

There are some people with Adhesive Capsulitis of the shoulder, or more commonly a “frozen shoulder,” who get a great benefit from cortisone injections, ART or Active Release Therapy, chiropractic manipulations, and sometimes no treatment at all, the problem “thaws,” out. PRP can also be beneficial in this situation even after failed cortisone. Please see our article: Frozen Shoulder – Adhesive Capsulitis: Injections, Physical Therapy and Surgery.

The rush to offer corticosteroid on the first visit – despite current medical guidelines

The rush to offer corticosteroid on the first visit - despite current medical guidelines

A May 2022 paper in the journal Family practice (1) examined how general practitioners made treatment recommendations to patients who walked into the office with new shoulder pain. The authors of this paper write: “Guidelines for shoulder pain in general practice recommend treatment with corticosteroid injections if initial pain management fails. However, little is known about the actual use and safety of corticosteroid injections in treatment by general practitioners.” What is being suggested is are general practitioners offering steroid shots when they may not be appropriate to offer?

To assess this line of thinking, the medical records of 200,000 patients were examined.


Comment: If you are older, have a history of shoulder pain, cortisone injection will be more likely.

Comparing PRP, Cortisone, and Prolotherapy

Platelet Rich Plasma Therapy (PRP). Sometimes PRP is referred to as PRP Therapy, PRP injection therapy, plasma replacement therapy, or simply PRP shots.

In this article, we will discuss new research on the clinical benefits of Platelet Rich Plasma Therapy (PRP) for people who are experiencing chronic shoulder pain from wear and tear type injury and for those whose chronic pain came after an acute injury.


Prolotherapy is an in-office injection treatment of simple dextrose or sugar. The science and research on Prolotherapy can be found on our Prolotherapy research page. At our center, we do not offer PRP as a stand-alone treatment. In the research below, you will see that PRP does not help everyone. Typically PRP fails when there is not enough treatment or it is not combined with other treatments that may make PRP work better. At our center, PRP is combined with Prolotherapy.

What is Prolotherapy? Is it like cortisone?

Prolotherapy is a regenerative injection treatment used to treat joint and spine pain by repairing damaged and weakened ligaments and tendons.

Because your shoulder pain may not be a primary problem of inflammation
Research comparing PRP, Cortisone, and Prolotherapy

Cortisone is an anti-inflammatory medication. Platelet Rich Plasma and Prolotherapy are Pro-inflammatory treatments. What does this mean? Cortisone acts to reduce swelling and thereby reduce pain. It does not fix what is causing the swelling. PRP and Prolotherapy injections attempt to fix soft tissue damage and thereby remedy the cause of inflammation. The differences in treatments are seen in the fact that initially, cortisone works better than PRP. According to numerous papers, long-term, PRP works better than cortisone.

Research comparing PRP and Cortisone

Doctors at the All India Institute of Medical Sciences published a paper in the journal Clinics in shoulder and elbow (3) evaluating the effectiveness of autologous platelet-rich plasma (PRP) injections in the treatment of common shoulder diseases. To do this the researchers examined previously published randomized controlled trials of PRP versus a control.

Conclusions: “PRP injections could provide better pain relief and functional outcomes than other treatments for persons presenting with common shoulder diseases. PRP injections have a greater capacity to improve shoulder-related quality of life than other interventions.”


Case history

The image below presents a case history. Some explanatory notes are added to help explain this case better:

Case study. Glenoid labral tear, impingement, and osteoarthritis of the right shoulder.

In this case history, the patient suffered from unbearable shoulder pain for about a year. This pain could be traced back to shoulder problems that had developed over a 25-year history related to a clavicle fracture she sustained in a bike injury.

Her pain was constant and sharp referring to pain in her neck, chest, and thoracic area and limiting her motion. She was only able to perform 50% of her daily activities and the pain was hindering her ability to play tennis.

Her MRI showed bursitis, loose bodies, a labral tear, and osteoarthritis. Surgery and physical therapy were recommended by another provider. This patient was more familiar with regenerative medicine techniques and chose the non-surgical option instead – EIGHT treatments were originally estimated to be necessary but after 3 PRP Prolotherapy treatments the patient-reported vast improvement over 90% return to playing doubles tennis twice weekly in addition to golfing and enjoying a very active lifestyle.

Learning point:

Comments: This is something we see very frequently in people who contact us after they have had a single PRP injection. Cortisone is a one-shot treatment, PRP should not be given the same way.

People get confused with PRP treatment because they think it is “just like cortisone, only safer.” PRP is NOT just like cortisone. Cortisone has an immediate pain-reducing effect for many people, not all, because it is reducing pain brought on by chronic inflammation. Nothing is being healed. PRP brings healing through inflammation. When tissue is repaired, the inflammation goes away.


My doctor wants to give me cortisone and PRP in my shoulder

In some people that we see at our center or contact us, they will tell us about their other doctor’s desire to use cortisone and PRP together at the same treatment. For some people, this has worked. These are typically not the people we see at our center. We see the people who may have tried cortisone and/or PRP at other clinics and have come to us because the effects were off or were not what they expected.

Injecting both cortisone and PRP is something we will not do. In over 28 years of treating thousands of patients, and having published numerous research papers, we do not see the benefit of this combined treatment as a standard of care. Please see our article on cortisone injections.


In this video, a general demonstration of Prolotherapy and PRP treatment is given for a patient with repeated shoulder dislocations – there is no cortisone in these injections.

Danielle R. Steilen-Matias, MMS, PA-C narrates the video and is the practitioner giving the treatment:

Summary and contact us. Can we help you?

We hope you found this article informative and it helped answer many of the questions you may have surrounding your shoulder problems.  If you would like to get more information specific to your challenges please email us: Get help and information from our Caring Medical staff

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1 van Doorn PF, Schiphof D, Rozendaal RM, Ottenheijm RP, van der Lei J, Bindels PJ, de Schepper EI. The use and safety of corticosteroid injections for shoulder pain in general practice: a retrospective cohort study. Family Practice. 2022 Jun;39(3):367-72. [Google Scholar]
3 Barman A, Mishra A, Maiti R, Sahoo J, Thakur KB, Sasidharan SK. Can platelet-rich plasma injections provide better pain relief and functional outcomes in persons with common shoulder diseases: a meta-analysis of randomized controlled trials. Clinics in shoulder and elbow. [Google Scholar]
7 Kwong CA, Woodmass JM, Gusnowski EM, Bois AJ, Leblanc J, More KD, Lo IK. Platelet-Rich Plasma in Patients With Partial-Thickness Rotator Cuff Tears or Tendinopathy Leads to Significantly Improved Short-Term Pain Relief and Function Compared With Corticosteroid Injection: A Double-Blind Randomized Controlled Trial. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2020 Oct 28. [Google Scholar]
8 Dadgostar H, Fahimipour F, Sabagh AP, Arasteh P, Razi M. Corticosteroids or platelet-rich plasma injections for rotator cuff tendinopathy: a randomized clinical trial study. Journal of Orthopaedic Surgery and Research. 2021 Dec;16(1):1-8. [Google Scholar]

This article was updated October 25, 2021



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