How stem cells help fix a broken “healing cycle”

Prolotherapy Knee articular cartilage repair without surgery

Ross Hauser, MD

Medical university researchers in Spain examined the role of systemic inflammation in older adults with osteoarthritis and the factors associated with osteoarthritic progression, pain and functional impairment. Simply, you can call this a broken “healing cycle,” in patients.

Before reading on, if you have questions about your joint pain, get help and information from our Caring Medical staff

What causes a broken healing cycle?

The researchers then explained that a wide range of evidence indicates that intra-articular injection of adipose-derived mesenchymal stem cells, alone or associated to growth factors and/or scaffolds, can improve cartilage quality in osteoarthritis and therefore fix the healing cycle. However, cartilage reapir may nonly be one factor. Cell signaling or the paracrine effect may have therapeutic potential in the down-regulation of inflammatory and catabolic mediators and exert protective effects by countering inflammatory stress.1 Simply, the stem cells are turning off the systemic inflammation (inflammatory stress) that has not been effective, it is shutting down the disease environment so a new healing environment can be created.

In Caring Medical research we published in 2013 in the medical journal Clinical medicine insights. Arthritis and musculoskeletal disorders, we were able to show that Prolotherapy, Platelet rich Plasma Therapy, and in this instance bone marrow aspirate (stem cells and healing factors)  supported chondrogenesis (Cartilage growth and repair) by enhancing the availability of pro-chondrogenic microenvironmental factors. In essence an environmental change from diseased to healing within the osteoarthritic joint.

This was achieved in our study by a combination of the above treatments.

While treatments based on either stem cells or the other mentioned treatments show effectiveness for osteoarthritis as a stand alone or single therapy, treatments that combine these modalities may be especially promising.

I cover the subject of combined treatments in these articles Stem Cell Therapy and Platelet Rich Plasma Therapy when to use both

If you have questions about your joint pain, get help and information from our Caring Medical staff

1 Platas J, Guillén MI, del Caz MDP, et al. Paracrine effects of human adipose-derived mesenchymal stem cells in inflammatory stress-induced senescence features of osteoarthritic chondrocytes. Aging (Albany NY). 2016;8(8):1703-1717. [Pubmed]

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