Venous insufficiency – Chronic Cerebrospinal Venous Insufficiency and neurologic-like problems

Ross Hauser, MD

Chronic cerebrospinal venous insufficiency is in some medical circles considered very controversial. It is a problem of blood outflow from the brain. The controversy stems from the identification of Chronic cerebrospinal venous insufficiency as a possible cause in Multiple Sclerosis. This article is not about this controversy. This article is about problems of compression and slow or interrupted drainage or outflow of the blood from the brain via the internal jugular veins that may cause some neurologic-type symptoms.

In this article we discuss symptoms and conditions of Chronic Cerebrospinal Venous Insufficiency outside of a primary diagnosis of Multiple Sclerosis, Alzheimer’s Disease, and Parkinson’s Disease. At our center we do not treat these diseases, we treat craniocervical instability, upper cervical spine instability, cervical spine instability, or problems related to neck pain and loss of cervical spine curvature that may share common symptoms and characteristics of neurological-like and vascular-like disorders such as those just mentioned.

This article is a companion article to my other articles on this website. Please see:

What are we seeing in this image? The many names and consequences of Chronic Cerebrospinal Venous Insufficiency

The caption reads: 70% of the blood in the brain is in the venous system. If venous outflow disturbance exists it can turn the brain into a clogged toilet and potentially cause a cascade of neuro-catastrophic symptoms. The image lists these varying names for Chronic Cerebrospinal Venous Insufficiency.

The controversy surrounding chronic cerebrospinal venous insufficiency as a cause of multiple sclerosis

I will only touch briefly on this topic as the controversy has been well documented and covered by such groups as the National Multiple Sclerosis Society.

In 2010, Italian researcher Paolo Zamboni published a paper in the Journal of neurology, neurosurgery, and psychiatry (1) in which he documented the “extracranial venous outflow routes in clinically defined multiple sclerosis.” What he suggested was “clinically defined multiple sclerosis is strongly associated with Chronic cerebrospinal venous insufficiency, a scenario that has not previously been described, characterized by abnormal venous haemodynamics determined by extracranial multiple venous strictures of unknown origin.” Basically the suggestion is that chronic cerebrospinal venous insufficiency can cause multiple sclerosis.

Over the years treatments including stenting and balloon angioplasty have been suggested and tried and the results where less than hoped for. In fact it was almost immediate, in 2010, that researcher Jane Qiu wrote in the prestigious medical journal Lancet (2) : “Recent reports of a possible link between venous abnormalities and multiple sclerosis have been associated with high levels of media hype. Many experts caution against premature promotion of the hypothesis and call for objectivity and skepticism in follow-up studies. Poor judgment in medicine can lead to interventions with fatal consequences. Lives should not be lost before these interventions are halted, but they often are. In August, 2009, a patient with multiple sclerosis (MS) had two stents inserted into her right jugular vein; she died shortly afterwards of a brain hemorrhage while on the anticoagulant warfarin as a result of the procedure. 3 months later, another patient with MS had to have open-heart surgery to remove a jugular-vein stent that had come loose and moved into the right ventricle.”

A 2019 study in the journal Reviews on Recent Clinical Trials (3) examined the Chronic Cerebrospinal Venous Insufficiency and its relationship with Multiple Sclerosis and found that this condition could be prevalent in other disorders. Here is what the researchers wrote:

“About 10 years ago, the so-called chronic cerebrospinal venous insufficiency syndrome was discovered. This clinical entity, which is associated with extracranial venous abnormalities that impair venous outflow from the brain, was initially found exclusively in multiple sclerosis patients. Currently, we know that such venous lesions can also be revealed in other neurological pathologies, including Alzheimer’s and Parkinson’s diseases. Although the direct causative role of chronic cerebrospinal venous insufficiency in these neurological diseases still remains elusive, in this paper, we suggest that perhaps abnormal venous drainage of the brain affects the functioning of the glymphatic system (the waste clearance system of the central nervous system) which in turn results in the accumulation of pathological proteins in the cerebral tissue (such as β-synuclein, β-amyloid, and α-synuclein) and triggers the venous outflow from the cranial cavity and circulation of the cerebrospinal fluid in the settings of neurodegenerative disease.”

In this paper, there is an identification with the brain being unable to drain wastes and that these accumulated wastes would lead to degenerative disorders. We find here similarities in our cervical spine instability patients. We will discuss this important concept below.

Now in 2021 the understanding that chronic cerebrospinal venous insufficiency can cause multiple sclerosis has been disputed, the use of stents and balloon angioplasty or venoplasty to treat multiple sclerosis was not supported in a 2018 paper published in the journal Neurology (4).

Chronic Cerebrospinal Venous Insufficiency and neurologic-like problems

Let’s begin this section with a patient study of 128 people diagnosed with Chronic Cerebrospinal Venous Insufficiency or CCSVI. This is an international study which includes neurologists, brain disorder specialists, neuroscientists, and of course the 128 patients. It was published in the journal Frontiers in neurology (5) in September 2020.

In this paper the researchers wrote: “The cerebrospinal venous system is a crucial channel for the cerebral venous outflow, which plays an important role in transporting metabolic wastes, collecting cerebral spinal fluid, and regulating intracranial pressure. Intracranial venous outflow insufficiency has attracted much attention in clinical practice due to the typical symptoms. However, as an indispensable part of the cerebral venous system, the disturbance of the extracranial cerebrospinal venous system is far from fully recognized by the non-specific clinical presentations and inadequate awareness .  The researchers noted that their previous study “showed that  CCSVI might be relevant to an independent disease entity, with non-focal neurological symptoms such as sleep disturbance, tinnitus, head noise, dizziness, and headache whereas without specific clinical signs and imaging findings in the brain, misdiagnosis or missed diagnosis is common.”

Let’s look at the study’s patient group:

So there you have a profile of the patient. Next let’s see what they told the doctors of this study bothered them the most by way of symptoms:

A video presentation: A story of a patients who went from being “in great shape” to one that is almost completely disabled following an injury event.

Regenerative Medicine specialist, Ross Hauser, MD, and cervical curve correction specialist, Brian Hutcheson, DC, discuss a couple recent case presentations of suspected Chronic Cerebrospinal Venous Insufficiency – Compression of the Internal Jugular Vein from Cervical Instability. They discuss some of the symptoms that patients with these findings complain of, including swishing sounds in their ears, eyeball pressure, head pressure, severe brain fog, and other symptoms.

A story of a patients who went from being “in great shape” to one that is almost completely disabled following an injury event.

This patient had an unbelievable amount of brain fog, constant head pressure that won’t go away, there were several times where she almost passed out. In her consultation I explained to her that many of the patients that have her kind of symptoms, when they come to the office we diagnose them with chronic cerebrospinal venous insufficiency. This is a compression of the jugular vein. I also explained to her that we assess this problem with testing.

What are we seeing in this image? Testing for Internal Jugular Vein Stenosis induced by the C1 transverse mass

Here we have neuroimaging features of the right Internal Jugular Vein Stenosis induced by the C1 transverse mass. Sagittal or side view (A); Axial view (horizontal plane) and D reconstructive (D) CTV images revealing the right transverse mass of C1 compression on the right Internal Jugular Vein. Magnetic resonance venography (C) revealing the right IJV-J3 segment stenosis accompanied by substantially abnormal collateral veins.

This image comes from a paper published in January 2020 in the journal CNS neuroscience and therapeutics (6) In this paper doctors, moreso, neurologists, describe a condition of “cervical spondylotic internal jugular venous compression syndrome.”

This is what they wrote: “Although traditional cervical spondylosis including radiculopathy, myelopathy, axial neck pain and vertebral artery insufficiency has been frequently reported in the literature (medical research), studies focusing on cervical spondylosis‐induced venous outflow disturbance are still lacking. In our clinical practice, we have noticed that a large percentage of Internal Jugular Vein Stenosis patients display with osseous (bone) impingement or compression, with the first cervical vertebra (atlas, C1) being the major contributor. As the Internal Jugular Vein passes over the anterior (front) aspect of the transverse process of C1 and once the cervical vertebral structure changes, this Internal Jugular Vein segment is likely to be compressed. Given that, we bring forward a novel concept: “cervical spondylotic internal jugular venous compression syndrome,” to depict the clinical presentations and imaging features in patients with this issue.

Her head was tilted downward, this head position alleviated her symptoms.

I explained to this patient that in a specific position, when you lay down and your chin is closer to your chest, that normally patients report that they feel better in this position. The patient replied that “I would lay down and I wouldn’t feel better when my chin is up,  but I have this certain recliner chair and it whenever I’m in that I feel so much better. I can watch TV for a long time. But every place else, when I am not in this recliner, I can’t think straight. I almost feel like I don’t exist anymore, like there’s somebody else in my body.” This person is a highly intelligent young person. What we found was that in this reclining chair, her head was tilted downward, this head position alleviated her symptoms.

What are we seeing in this image?

Dr. Hauser is pointing to the CT Scan. It is demonstrating that the Internal Jugular Vein is being compressed by the C1 vertebrae. The problem with CT Scans is that the image in taken in neutral position or static position where in our office we do motion imagery.

Jugular venous outflow disturbance

I want to remind the reader that much of the research that we examine here and the topic of Chronic Cerebrospinal Venous Insufficiency is controversial. However, doctors, as in the research presented here, are coming to an understanding of how venous outflow can present in patients with neurological-type symptoms.

A 2018 paper published in the journal CNS neuroscience and therapeutics (7) offers this explanation:

“Extracranial venous abnormalities, especially jugular venous outflow disturbance, were originally viewed as nonpathological (not a specific disorder) phenomena due to a lack of realization and exploration of their feature and clinical significance.”

“The etiology and pathogenesis are still unclear, whereas a couple of causal factors have been conjectured. The clinical presentation of this condition is highly variable, ranging from insidious (developing over time) to symptomatic, such as headaches, dizziness, pulsatile tinnitus, visual impairment, sleep disturbance, and neck discomfort or pain.”

The treatment suggested in this research is of a surgical nature.

“Standard diagnostic criteria are not available, and current diagnosis largely depends on a combinatory use of imaging modalities. Although few researches have been conducted to gain evidence-based therapeutic approach, several recent advances indicate that intravenous angioplasty in combination with stenting implantation may be a safe and efficient way to restore normal blood circulation, alleviate the discomfort symptoms, and enhance patients’ quality of life.

In addition, surgical removal of structures that constrain the internal jugular vein may serve as an alternative or adjunctive management when endovascular intervention is not feasible. Notably, discussion on every aspect of this newly recognized disease entity is in the infant stage and efforts with more rigorous designed, randomized controlled studies in attempt to identify the pathophysiology, diagnostic criteria, and effective approaches to its treatment will provide a profound insight into this issue.”

Adult-onset Hydrocephalus

In this image we see blockage of the cerebrospinal fluid flow from upper cervical instability.

A December 2020 paper in the journal CNS neuroscience (8) and therapeutics describes idiopathic normal pressure hydrocephalus as the most common type of adult-onset hydrocephalus and that this is a potentially reversible neuropsychiatric entity characterized by dilated ventricles, cognitive deficit, gait apraxia (walking difficulties because of brain injury), and urinary incontinence.

The researchers note: “Despite its relatively typical imaging features and clinical symptoms, the pathogenesis and pathophysiology of idiopathic normal pressure hydrocephalus remain unclear. . . The common consensus is that ventriculomegaly (the ventricles appear larger than normal) resulting from cerebrospinal fluid (CSF) dynamics could initiate a vicious cycle of neurological damages in idiopathic normal pressure hydrocephalus. ”

At Caring Medical, there are many ways that we document conditions and components of a clogged brain drainage system

Summary and contact us. Can we help you? How do I know if I’m a good candidate?

We hope you found this article informative and it helped answer many of the questions you may have surrounding Venous insufficiency – Chronic Cerebrospinal Venous Insufficiency and neurologic-like problems. Just like you, we want to make sure you are a good fit for our clinic prior to accepting your case. While our mission is to help as many people with chronic pain as we can, sadly, we cannot accept all cases. We have a multi-step process so our team can really get to know you and your case to ensure that it sounds like you are a good fit for the unique testing and treatments that we offer here.

Please visit the Hauser Neck Center Patient Candidate Form

References

1 Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Tacconi G, Dall’Ara S, Bartolomei I, Salvi F. Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry. 2009 Apr 1;80(4):392-9. [Google Scholar]
2 Qiu J. Venous abnormalities and multiple sclerosis: another breakthrough claim?. The Lancet Neurology. 2010 May 1;9(5):464-5. [Google Scholar]
3 Simka M, Skuła M. Potential involvement of impaired venous outflow from the brain in neurodegeneration: Lessons learned from the research on chronic cerebrospinal venous insufficiency. Reviews on recent clinical trials. 2019 Dec 1;14(4):235-6. [Google Scholar]
4 Traboulsee AL, Machan L, Girard JM, Raymond J, Vosoughi R, Hardy BW, Emond F, Gariepy JL, Bone JN, Siskin G, Klass D. Safety and efficacy of venoplasty in MS: A randomized, double-blind, sham-controlled phase II trial. Neurology. 2018 Oct 30;91(18):e1660-8. [Google Scholar]
5 Wang Z, Ding J, Bai C, Ding Y, Ji X, Meng R. Clinical classification and collateral circulation in chronic cerebrospinal venous insufficiency. Frontiers in Neurology. 2020;11. [Google Scholar]
6 Ding JY, Zhou D, Pan LQ, Ya JY, Liu C, Yan F, Fan CQ, Ding YC, Ji XM, Meng R. Cervical spondylotic internal jugular venous compression syndrome. CNS neuroscience & therapeutics. 2020 Jan;26(1):47-54.
7 Zhou D, Ding JY, Ya JY, Pan LQ, Yan F, Yang Q, Ding YC, Ji XM, Meng R. Understanding jugular venous outflow disturbance. CNS neuroscience & therapeutics. 2018 Jun;24(6):473-82. [Google Scholar]
8 Wang Z, Zhang Y, Hu F, Ding J, Wang X. Pathogenesis and pathophysiology of idiopathic normal pressure hydrocephalus. CNS neuroscience & therapeutics. 2020 Dec;26(12):1230-40. [Google Scholar]

This article was updated September 3, 2021

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