Metabolic syndrome and osteoarthritis joint pain

Marion Hauser, MS, RD

Metabolic Syndrome is a precursor to diabetes, heart disease, and it could make healing more challenging. Metabolic Syndrome is categorized by a group of medical conditions that have in common an ability to increase levels of insulin production. This is primarily due to excessive carbohydrate intake and overeating.

Before you read on, if you have questions about Metabolic syndrome and osteoarthritis joint pain, get help and information form our Caring Medical staff

Some of the conditions associated with Metabolic Syndrome include:

When you gain weight, you gain osteoarthritis and joint pain

Dr. Karel Pavelka of the Czech republic has published his findings in the Fall 2017 issue of the Czech language journal Internal Medicine. Here are his bullet points:

Simply, inflammation that causes metabolic syndrome and osteoarthritis, travel the same pathways.

State Medical University researchers in Russia have published their observations on 164 patients with osteoarthritis. Eighty-two patients were diagnosed with Metabolic Syndrome, Eighty-two were not and used as controls.

In the 82 patients with Metabolic Syndrome, clear indications of the negative impact of the disorder were seen:

Doctors in France, cited these same findings in their research on factors affecting joint healing and metabolic syndrome: They write in Current opinion in rheumatology:

Obesity related synovitis comes before cartilage deterioration

University researchers in Australia write in the journal PLoS One (Public Library of Science one) of the established risks obesity plays in osteoarthritis. In this research the Australian team looked for a connection between inflammation, obesity, and osteoarthritis.

The researchers fed Wistar rats a high-carbohydrate, high-fat diet for period of 8 and 16 weeks. The study showed that, obesity induced by this diet is associated with spontaneous and local inflammation of the synovial membranes in the rats even before the cartilage degradation.

This was followed by increased synovitis and increased macrophage infiltration (immune cells are now invading the areas causing swelling and edema) into the synovium and a predominant elevation of pro-inflammatory M1 macrophages (A specific type of immune cell).

This study demonstrates a strong association between obesity and a dynamic immune response locally within synovial tissues before cartilage degradation.4

In other words the joint environment is becoming a diseased joint environment on its way to joint death and joint replacement.

Knee pain is a whole body disease

Doctors in Spain in their research from February 2017 in the journal Maturitas also suggest that there needs to be an understanding of all the factors that can come into play in knee pain and joint breakdown and how these factors interact with each other.

These researchers looked at

As the typical characteristics of a patient with knee joint breakdown.5

Recognizing these problems early in joint pain treatment  may optimize the design of individualized treatments in osteoarthritis. The Spanish researchers suggest an identification and classification of patients, much like we do here at Caring Medical and Rehabilitation Services.

We look at the:

The problems of Insulin

Also from February 2017, doctors writing in the journal Medical hypotheses offered evidence making a connection between insulin, inflammation, and joint pain here are the bullet points of their findings.

Reducing circulation insulin levels can be achieved in many cases with health-professional guided lifestyle and dietary changes.

The same French team cited above also examined the recent advances in the knowledge of osteoarthritis and its association with obesity and metabolic syndrome through systemic mechanisms.

In (2016), type 2 diabetes has been described in two (studies) as an independent risk factor for osteoarthritis.” In these animal studies, diabetic rodents display a spontaneous and a more severe osteoarthritis than their non-diabetic counterparts.

The negative impact of diabetes on joints could be explained by the induction of oxidative stress and pro-inflammatory cytokines (systemic low grade inflammation) and by joint tissues exposed to chronic high glucose concentration. 7

We have more articles on this subject on this site, please see:

If you have questions about Metabolic syndrome and osteoarthritis joint pain, get help and information form our Caring Medical staff

1 Pavelka K. [Osteoarthritis as part of metabolic syndrome?] Vnitr Lek. 2017 Fall;63(10):707-711.
2 Vasilyeva LV, Lakhin DI. Clinical features of osteoarthritis in patients with metabolic syndrome. Terapevticheskii arkhiv. 2017;89(5):65.
3 Courties A, Sellam J, Berenbaum F. Metabolic syndrome-associated osteoarthritis. Curr Opin Rheumatol. 2017 Mar;29(2):214-222..
4 Sun AR, Panchal SK, Friis T, Sekar S, Crawford R, Brown L, Xiao Y, Prasadam I. Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis. PLoS One. 2017 Aug 31;12(8):e0183693. doi: 10.1371/journal.pone.0183693. eCollection 2017.
5 Herrero-Beaumont G, Roman-Blas JA, Bruyère O, Cooper C, Kanis J, Maggi S, Rizzoli R, Reginster JY. Clinical settings in knee osteoarthritis: Pathophysiology guides treatment. Maturitas. 2017 Feb;96:54-57. [Pubmed]
6 Askari A, Ehrampoush E, Homayounfar R, Bahramali E, Farjam M. Serum insulin in pathogenesis and treatment of osteoarthritis. Med Hypotheses. 2017 Feb;99:45-46.
7 Courties A, Sellam J. Osteoarthritis and type 2 diabetes mellitus: What are the links? Diabetes Res Clin Pract. 2016 Dec;122:198-206. doi: 10.1016/j.diabres.2016.10.021. Epub 2016 Nov 5.



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