Hyaluronic acid vs platelet-rich plasma in the treatment of hip osteoarthritis

Danielle.Steilen.ProlotherapistDanielle R. Steilen-Matias, MMS, PA-C

In this article Danielle Steilen-Matias, MMS, PA-C discusses Hyaluronic acid vs platelet-rich plasma in the treatment of hip osteoarthritis.

Do you have a question about hip osteoarthritis? Get help and information from our Caring Medical staff

We do not recommend viscosupplementation for hip osteoarthritis

Researchers in Brazil publishing in the August 2017 edition of Archives of physical medicine and rehabilitation had this to say about using hyaluronic acid injections for hip osteoarthritis:

A multi-national team of researchers from Israel, the United States, Italy, and Portugal published their findings in the medical journal Cartilage which suggested beneficial results for PRP Platelet Rich Plasma therapy  in the treatment of hip osteoarthritis. In this research 29 medical studies were evaluated, in eleven of them a comparison was made between PRP and hyaluronic acid injections. The doctors noted that patients treated with PRP showed significantly better results than hyaluronic acid groups.(2)

Doctors in Italy publishing in the American Journal of Sports Medicine also evaluated the effectiveness of intra-articular platelet-rich plasma injections versus hyaluronic acid injections for hip osteoarthritis.

A total of 111 patients were randomly assigned to 3 different study groups and each received 3 weekly injections of either

Why use both PRP and Hyaluronic Acid?
The idea is that while PRP rebuilds hip tissue, Hyaluronic Acid will act as a lubricant to help the PRP work better. As the research shows that did not happen.

The conclusion the doctors reached was that their results indicated that intra-articular PRP injections offer a significant clinical improvement in patients with hip osteoarthritis without relevant side effects.

The benefit was significantly more stable up to 12 months as compared with the other tested treatments. The addition of PRP + Hyaluronic Acid did not lead to a significant improvement in pain symptoms.(3)

In another study in the medical journal Orthopedics, doctors said both PRP and Hyaluronic acid both worked well for patients with hip osteoarthritis, these researchers however offered a conflicting assessment.

Intra-articular injections of platelet-rich plasma and hyaluronic acid represent effective medical treatments for osteoarthritis. This study’s goals were to compare the clinical efficacy of platelet-rich plasma and hyaluronic acid at 12 month follow-up in hip osteoarthritis patients

One hundred patients with chronic hip were consecutively enrolled and randomly assigned to 1 of 2 groups:

The conclusion these researchers reached was: Intra-articular injections of PRP are effective in terms of functional improvement and pain reduction but are not superior to hyaluronic acid in patients with symptomatic hip osteoarthritis at 12-month follow-up.(4)

While these studies show good results, we find more effective results can be achieved by treating the whole hip joint and surrounding ligaments and tendons to stabilize hip instability. Please read our article Treating Degenerative Hip Disease


Do you have a question about hip osteoarthritis? Get help and information from our Caring Medical staff

1 Leite VF, Amadera JE, Buehler AM. Viscosupplementation for hip osteoarthritis: a systematic review and meta-analysis of the efficacy for pain, disability and adverse events. Archives of Physical Medicine and Rehabilitation. 2017 Aug 11. [Google Scholar]

2 Laver L, Marom N, Dnyanesh L, Mei-Dan O, Espregueira-Mendes J, Gobbi A. PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies. Cartilage. 2016 Sep 1:1947603516670709.[Google Scholar]

3 Dallari D, Stagni C, Rani N, Sabbioni G, Pelotti P, Torricelli P, Tschon M, Giavaresi G.Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in Combination, for Hip Osteoarthritis: A Randomized Controlled Study. Am J Sports Med. 2016 Mar;44(3):664-71. doi: 10.1177/0363546515620383. Epub 2016 Jan 21. [Google Scholar]

4 Battaglia M, Guaraldi F, Vannini F, Rossi G, Timoncini A, Buda R, Giannini S. Efficacy of ultrasound-guided intra-articular injections of platelet-rich plasma versus hyaluronic acid for hip osteoarthritis. Orthopedics. 2013 Dec;36(12):e1501-8. [Google Scholar]


Make an Appointment |

Subscribe to E-Newsletter
Find out if you are a good candidate
First Name:
Last Name:

Enter code:

for your symptoms

Prolotherapy, an alternative to surgery

Were you recommended SURGERY?
Get a 2nd opinion now!

★ ★ ★ ★ ★We pride ourselves on 5-Star Patient Service!Come see why patients travel from all
over the world to visit our clinics.
Current Patients
Become a New Patient

Chicagoland Office
715 Lake St., Suite 600
Oak Park, IL 60301
(708) 393-8266 Phone
(855) 779-1950 Fax
Southwest Florida Office
9738 Commerce Center Ct.
Fort Myers, FL 33908
(239) 308-4701 Phone
(855) 779-1950 Fax Fort Myers, FL Office
We are an out-of-network provider.
© 2018 | All Rights Reserved | Disclaimer
National Prolotherapy Centers specializing in Comprehensive Prolotherapy,
Stem Cell Therapy, and Platelet Rich Plasma.

Meet our Prolotherapy Doctors and check out our Prolotherapy research.